Consequences of Inflammation on Muscle Following Hip Fracture

髋部骨折后肌肉炎症的后果

• 批准号: 7812036
• 负责人: Ram R Miller
• 金额: $ 16.17万
• 依托单位: UNIVERSITY OF MARYLAND BALTIMORE
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-05-01 至 2013-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7812036
• 关键词: Acute; Aging; Anti-Inflammatory Agents; Anti-inflammatory; Area; Biological; Biological Markers; Boston; Cardiac Surgery procedures; Clinical; Data; Development; Development Plans; Elderly; Environment; Epidemiology; Event; Exercise; Fracture; Frail Elderly; Frail Older Adults; Future; Geriatrics; Gerontology; Goals; Head; Heterogeneity; Hip Fractures; Human; Inflammation; Inflammatory; Inflammatory Response; Interleukin-10; Interleukin-6; Intervention; Knowledge; Lower Extremity; Maryland; Master' s Degree; Measures; Mediating; Medical; Mentorship; Muscle; Physical Function; Physiological; Preventive Medicine; Process; Quality of life; Reaction; Recovery; Recovery of Function; Rehabilitation therapy; Research; Research Personnel; Residual state; Scanning; Serum; Study models; Testing; Therapeutic; Thigh structure; Training; Universities; Vitamin D; Woman; Work; X-Ray Computed Tomography; abstracting; anakinra; attenuation; career development; cytokine; design; disability; disability burden; experience; frailty; functional loss; high risk; improved; inflammatory marker; interest; intervention effect; investigator training; men; muscle strength; professor; programs; response; sarcopenia; tool

DESCRIPTION (provided by applicant): The proposal outlines the career development plan for a young investigator with an interest in epidemiological and clinical approaches to the study of the underlying causes of disability in older adults following acute events such as hip fracture. Training investigators, with an interest in this area is important, because in order to maintain independence in older adults we must first understand the causes of disability. ABSTRACT: Dr. Ram Miller is an Assistant Professor in the Division of Gerontology, Department of Epidemiology and Preventive Medicine, at the University of Maryland. He trained in Geriatric Medicine and received a Masters degree in epidemiology from Boston University. In this proposal, under mentorship of Dr. Jay Magaziner, Head of the Division of Gerontology, who is known for his extensive work related to recovery from hip fracture and Dr. Luigi Ferrucci, a Geriatrician renowned for his work on aging and the mechanisms of frailty, Dr. Miller outlines a career development plan that will enable him to become an independent researcher. In elders, higher serum levels of inflammatory cytokines have been associated with sarcopenia, decreased strength and functional loss. Whether the functional loss seen following hip fracture is mediated by changes in muscle due to the negative effects of inflammation is not known. In Specific Aim 1; Dr. Miller proposes to determine the change in inflammatory cytokine levels following hip fracture in older adults. Specific Aim 2; he will prospectively examine the effects of inflammation on muscle in older adults post hip fracture. Specific Aim 3; he will prospectively examine factors that may influence the inflammatory response and subsequent changes in muscle following hip fracture including the effect of intervention with exercise and vitamin D. Dr. Miller's strong mentorship, supportive environment, carefully designed career development program and research plan will give him the experience and tools needed for him to develop into a sucessful independent researcher studying the mechanisms that underlie the association of inflammation with functional loss and recovery in older adults.

描述（由申请人提供）：该提案概述了一名年轻调查员的职业发展计划，该计划对流行病学和临床方法感兴趣，以研究急性事件（例如髋部骨折）的老年人的潜在残疾根本原因。对该领域感兴趣的培训调查人员很重要，因为为了维持老年人的独立性，我们必须首先了解残疾的原因。摘要：拉姆·米勒（Ram Miller）博士是马里兰大学流行病学和预防医学系老年医学系的助理教授。他接受了老年医学培训，并获得了波士顿大学流行病学硕士学位。在这项建议中，在杰伊（Jay Magaziner）博士的指导下，杰伊·杂志（Jay Magaziner）的老年病学系主任，他以与髋部骨折的康复有关的广泛工作而闻名。在长者中，较高的血清炎性细胞因子水平与肌肉减少症相关，强度降低和功能损失。尚不清楚由于炎症的负面影响，髋部骨折后看到的功能损失是否是由肌肉变化介导的。在特定目标1中；米勒博士建议确定老年人髋部骨折后炎症细胞因子水平的变化。具体目标2；他将前瞻性检查髋部骨折后老年人炎症对肌肉的影响。具体目标3;他将前瞻性研究可能影响髋部骨折后炎症反应和随后的肌肉变化的因素，包括运动和维生素D的干预效果。Miller博士的强大指导，支持性环境，精心设计的职业发展计划和研究计划将为他带来他所需的经验和工具，使他能够成长为丧失症状的丧失和疾病的疾病，使他能够成长为成人的丧失和疾病的疾病，并具有成年的疾病，并具有成年的相关性。