Amyloid PET in AD, FTLD & PPA: Diagnosis, Functional & Structural Correlations

AD、FTLD 中的淀粉样蛋白 PET

基本信息

批准号：
7898716
负责人：
Gil Dan Rabinovici
金额：
$ 15.93万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
起止时间：
2008-09-30 至 2013-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7898716
关键词：
Alzheimer&apos s Disease Amyloid Amyloid beta-Protein Amyloid deposition Anatomy Aphasia Autopsy Behavioral Bilateral Binding Biological Markers Biology Biometry Brain Brain imaging Brain region Caring Characteristics Clinical Clinical Distribution Cognitive Data Analyses Dementia Development Diagnosis Diagnostic Diagnostic tests Differential Diagnosis Diffuse Discrimination Disease Evaluation Frontotemporal Lobar Degenerations Genetic Glucose Goals Gold Grant Healthcare Histopathology Image Imaging Techniques Instruction K-Series Research Career Programs Language Lateral Left Lesion Ligands Magnetic Resonance Imaging Measurement Measures Medial Memory Disorders Mentors Molecular Morbidity - disease rate Neurobiology Neurodegenerative Disorders Neurons Neurosciences Parietal Pathogenesis Pathologic Pathology Patients Pattern Phenotype Pittsburgh Compound-B Positron-Emission Tomography Primary Progressive Aphasia Principal Investigator Receptive aphasia Research Research Personnel Resources Role Scanning Semantic Dementias Series Side Structure Syndrome Temporal Lobe Testing Thick Tracer Training Training Programs Variant Writing age related amyloid pathology aphasic base cerebral atrophy clinical Diagnosis cognitive system diagnosis standard diagnostic accuracy glucose metabolism improved in vivo indexing molecular imaging mortality neuroimaging neuropathology novel research clinical testing research study responsible research conduct tool uptake

项目摘要

DESCRIPTION (provided by applicant): This is an application for a K-23 Mentored Career Development Award entitled "Amyloid PET in AD, FTLD & PPA: Diagnosis, Functional & Structural Correlations." The primary goal of the proposed research is to apply PET imaging with the amyloid-beta (AP) ligand Pittsburgh Compound-B (PIB) towards the differential diagnosis of dementia, while simultaneously studying the relationships between amyloid deposition, clinical presentation, and brain structure and function. Alzheimer's disease (AD) and frontotemporal lobar degeneration (FTLD) are two leading causes of dementia with distinct histopathologies. Primary progressive aphasia (PPA) is a clinical syndrome that can be caused by FTLD or (less commonly) AD pathology. PIB is a novel PET tracer that specifically binds Ap amyloid, a pathologic hallmark of AD that is not part of the FTLD spectrum. The specific aims of this study are: (1) To measure the utility of PIB-PET in distinguishing AD and FTLD; (2) To identify clinical features that predict the presence of Ap amyloid in PPA and FTLD, and thereby refine diagnostic criteria; (3) To study the relationships between clinical presentation, regional Ap amyloid deposition and neuronal functional and structural integrity using PIB-PET, FDG-PET, and MRI-based cortical thickness measurements. Overall, the proposal seeks to establish PIB-PET as an important clinical tool for improving diagnostic accuracy in dementia, and an important scientific tool for studying the role of Ap amyloid in the pathogenesis of AD. The applicant's long-term goal is to become an independent translational investigator in dementia with expertise in structural, functional and molecular neuroimaging. The applicant seeks training in: (1) neuroimaging, (2) neuropathology and neurobiology of -disease, (S)-biomarker analysis,. (4.) .biostatistics and. data analysis, (5) cognitive and systems neuroscience, (6) clinical dementia care, (7) presentation, Dublication and grant writing and (8) responsible conduct of research. The training program includes mplementing the proposed research plan, didactic courses and instruction from mentors and consultants. Dementia is a leading cause of age-related morbidity and mortality, and a growing strain on health-care resources. The proposed research studies the potential of a new brain imaging technique to improve diagnostic accuracy in dementia, and to study the biology of Alzheimer's disease.

描述（由申请人提供）：这是一份 K-23 指导职业发展奖申请，题为“AD、FTLD 和 PPA 中的淀粉样蛋白 PET：诊断、功能和结构相关性”。该研究的主要目标是将 β 淀粉样蛋白 (AP) 配体匹兹堡化合物 B (PIB) 的 PET 成像应用于痴呆症的鉴别诊断，同时研究淀粉样蛋白沉积、临床表现和大脑结构之间的关系和功能。阿尔茨海默病（AD）和额颞叶变性（FTLD）是痴呆症的两个主要原因，具有不同的组织病理学。原发性进行性失语 (PPA) 是一种临床综合征，可由 FTLD 或（不太常见）AD 病理引起。 PIB 是一种新型 PET 示踪剂，可特异性结合 Ap 淀粉样蛋白，Ap 淀粉样蛋白是 AD 的病理标志，不属于 FTLD 谱。本研究的具体目的是：（1）衡量PIB-PET在区分AD和FTLD方面的效用； (2) 确定预测 PPA 和 FTLD 中存在 Ap 淀粉样蛋白的临床特征，从而完善诊断标准； (3) 使用 PIB-PET、FDG-PET 和基于 MRI 的皮质厚度测量来研究临床表现、区域 Ap 淀粉样蛋白沉积与神经元功能和结构完整性之间的关系。总体而言，该提案旨在将 PIB-PET 建立为提高痴呆症诊断准确性的重要临床工具，以及研究 Ap 淀粉样蛋白在 AD 发病机制中作用的重要科学工具。申请人的长期目标是成为一名独立的痴呆症转化研究者，拥有结构、功能和分子神经影像学方面的专业知识。申请人寻求以下方面的培训：(1) 神经影像学、(2) 疾病的神经病理学和神经生物学、(S)-生物标志物分析。 (4.).生物统计学和。数据分析，(5) 认知和系统神经科学，(6) 临床痴呆症护理，(7) 演示、复制和资助写作，以及 (8) 负责任的研究行为。培训计划包括实施拟议的研究计划、教学课程以及导师和顾问的指导。痴呆症是与年龄相关的发病率和死亡率的主要原因，并且对医疗保健资源造成越来越大的压力。拟议的研究研究了一种新的大脑成像技术的潜力，以提高痴呆症的诊断准确性，并研究阿尔茨海默病的生物学。