DETERMINING RAPIDITY THAT EXOGENOUS P SUPPRESSES DAYTIME LH PULSE FREQUENCY

确定外源性 P 抑制日间 LH 脉搏频率的速度

• 批准号: 8167174
• 负责人: Christopher Rolland McCartney
• 金额: $ 5.75万
• 依托单位: UNIVERSITY OF VIRGINIA
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-03-01 至 2013-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8167174
• 关键词: Acute; Adult; Computer Retrieval of Information on Scientific Projects Database; Crossover Design; Frequencies; Funding; Genetic Crossing Over; Grant; Hour; Institution; Menstrual cycle; Oral; Physiologic pulse; Placebos; Progesterone; Randomized; Research; Research Personnel; Resources; Sampling; Sampling Studies; Source; Suspension substance; Suspensions; United States National Institutes of Health; Woman; placebo controlled study; proliferative phase Menstrual cycle

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The rapidity with which P suppresses daytime LH (and by inference GnRH) pulse frequency is unknown. We propose to assess this further using a randomized, cross-over, placebo-controlled study. Ovulatory women pretreated with E2 will undergo a 24-h sampling study in the GCRC. After 10 h of sampling, either oral micronized progesterone (100 mg p.o.) suspension or placebo suspension will be administered (according to randomization). During a subsequent menstrual cycle, subjects will undergo another GCRC study identical to the first (including pretreatment with E2) except that oral progesterone will be exchanged for placebo or vice versa in accordance with the crossover design. We will assess the acute effects of progesterone on LH frequency, with secondary endpoints being mean LH, LH pulse amplitude, and mean FSH. We hypothesize that administration of P (at 0600 h) to adult women during the follicular phase will result in a demonstrable suppression of daytime LH (and by inference GnRH) pulse frequency within 12 hours.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 P抑制白天LH（和通过推理GNRH）脉冲频率的速度尚不清楚。我们建议使用一项随机，跨越的安慰剂对照研究进一步评估这一点。通过E2预处理的排卵女性将在GCRC中接受24小时的抽样研究。采样10小时后，要进行口服微元素孕酮（100 mg P.O.）悬浮液或安慰剂悬浮液（根据随机分组）。在随后的月经周期中，受试者将接受另一项与第一个相同的GCRC研究（包括使用E2进行预处理），但根据交叉设计将口服孕酮交换为安慰剂，反之亦然。我们将评估孕酮对LH频率的急性影响，次要终点为平均LH，LH脉冲振幅和平均FSH。我们假设在卵泡期对成年女性的P（0600 h）给药将在12小时内证明对白天LH（以及推理GNRH）脉冲频率的抑制作用。