MECHANISMS OF HYPEROXIA-INDUCED DEVELOPMENTAL PLASTICITY OF RESPIRATORY CONTROL

高氧诱导呼吸控制发育可塑性的机制

• 批准号: 8167702
• 负责人: RYAN W BAVIS
• 金额: $ 13.76万
• 依托单位: MOUNT DESERT ISLAND BIOLOGICAL LAB
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8167702
• 关键词: Acute; Address; Adult; Animals; Attenuated; Biomedical Research; Birds; Carotid Body; Cell Cycle; Clinical; Collaborations; Computer Retrieval of Information on Scientific Projects Database; Development; Disease; Environment; Exhibits; Fostering; Funding; Genes; Grant; Hyperoxia; Hypoxia; Institution; Life; Mammals; Modeling; Molecular; Mus; Oxygen; Perinatal; Quail; Rattus; Reflex action; Research; Research Personnel; Resources; Role; Scientist; Source; Students; System; United States National Institutes of Health; developmental plasticity; insight; neurotrophic factor; receptor; research study; respiratory; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The perinatal environment influences development of the respiratory control system in mammals and birds. We have been studying a model of developmental plasticity in which rats or quail are exposed to normobaric hyperoxia (60% oxygen) during development. These animals exhibit attenuated ventilatory responses to acute hypoxia as adults owing to abnormal development of the carotid body, but the cellular and molecular mechanisms by which hyperoxia alters carotid body development are only beginning to be revealed. Preliminary studies suggest that hyperoxia may impair carotid body development by changing the expression of neurotrophic factors or their receptors and/or by influencing genes that regulate the cell cycle. The proposed experiments address these hypotheses in rats, mice and quail, thereby providing valuable new insights into the role of the environment in the normal and pathological development of the respiratory control system. Abnormal development of the respiratory control system is implicated in many clinical disorders, so it is critical to understand how environmental conditions in early life influence protective ventilatory reflexes. Furthermore, this project enables undergraduate students to participate directly in biomedical research and fosters collaborations with regional scientists using similar or complementary research approaches.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 中心，不一定是研究者的机构。 围产期环境影响哺乳动物和鸟类呼吸控制系统的发育。我们一直在研究发育可塑性模型，其中大鼠或鹌鹑在发育过程中暴露于常压高氧（60％的氧气）。由于颈动脉体发育异常，这些动物在成年后表现出对急性缺氧的通气反应减弱，但高氧改变颈动脉体发育的细胞和分子机制才刚刚开始被揭示。初步研究表明，高氧可能通过改变神经营养因子或其受体的表达和/或影响调节细胞周期的基因来损害颈动脉体发育。拟议的实验在大鼠、小鼠和鹌鹑中解决了这些假设，从而为环境在呼吸控制系统正常和病理发育中的作用提供了有价值的新见解。呼吸控制系统的异常发育与许多临床疾病有关，因此了解生命早期的环境条件如何影响保护性通气反射至关重要。此外，该项目使本科生能够直接参与生物医学研究，并利用类似或互补的研究方法促进与地区科学家的合作。