WORKER PROTECTION AGAINST AIRBORNE INFLUENZA - A PILOT STUDY

保护工人免受空气传播的流感 - 试点研究

• 批准号: 8167059
• 负责人: WERNER E BISCHOFF
• 金额: $ 0.75万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-03-01 至 2011-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8167059
• 关键词: Air; Asia; Attenuated; Avian Influenza; Cessation of life; Computer Retrieval of Information on Scientific Projects Database; Data; Disease Outbreaks; Effectiveness; Epidemic; Evaluation; Feasibility Studies; Funding; Grant; Head; Health Personnel; Healthcare; Infection Control; Influenza; Institution; Life; Manikins; Masks; Measures; Mechanical Ventilators; Methods; Modeling; Operative Surgical Procedures; Pilot Projects; Public Health; Research; Research Design; Research Personnel; Resources; Rhinovirus; Route; Severities; Source; United States National Institutes of Health; Vaccination; Vaccines; Virus Diseases; Work; base; face mask; human subject; influenza virus strain; influenza virus vaccine; pandemic disease; pathogen; prevent; transmission process

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Airborne transmission represents one of the most rapidly spreading and least understood dissemination mechanisms for pathogens. Some of the most severe viral infections such as Influenza are spread by air. Influenza has caused three pandemics in the last century alone, with an overall death toll reaching tens of millions, and continues to cause annual epidemics of varying severity worldwide. The threat of another pandemic is increasing with the emergence of avian influenza strains in Asia. Public health strategies to prevent and control the often explosive outbreaks associated with these pathogens are limited to vaccination and treatment, if available, or isolation and barrier precautions. The latter includes the utilization of face masks to interrupt the chain of transmission. However, the scientific evidence regarding the efficacy of face masks has been solely based on studies using manikin heads. In continuation of our previous work with rhinovirus we propose to (1) adapt our existing model for airborne dispersal to live attenuated Influenza vaccine viruses (FluMist¿¿ vaccine), (2) determine the route of transmission, and (3) evaluate the effectiveness of surgical masks and N95 respirators, commonly used for protection of healthcare workers. This project is the first attempt to develop a method for evaluation of the utility and efficacy of face masks using viable Influenza virus strains in human subjects. The preliminary data generated in this project will confirm the feasibility of the study design, and, therefore, strengthen a R01 submission concerning the efficacy of established infection control measures for workers in the healthcare setting.

该副本是使用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这是调查员的机构。 空气传播是病原体最快传播和最不理解的传播机制之一。一些最严重的病毒感染（例如流感）是由空气传播的。仅在上个世纪，流感就引起了三个大流行病，总体死亡人数达到了数千万，并继续引起全球年度严重程度的年流行病。另一个大流行的威胁是随着亚洲鸟类影响菌株的出现而增加。 预防和控制与这些病原体相关的经常爆炸性暴发的公共卫生策略仅限于疫苗和治疗（如果有），或隔离和障碍预防措施。后者包括使用面罩来中断传输链。但是，关于面罩效率的科学证据仅基于使用Manikin头的研究。 在继续使用鼻病毒的工作中，我们建议（1）适应我们现有的空气传播模型，以使衰减的流感疫苗病毒病毒（Flumist¿疫苗），（2）确定传播途径，以及（3）评估手术口罩和N95呼吸器和N95呼吸器的有效性，并使用Neveralcare of Nearthcare of Nearthcare of Nearthcare of Nearthcare of Nearthcare of Nearthcare of Nearthcare shealthercare of Nearthcare sartencare。 该项目是开发一种使用可行的流感病毒菌株在人类受试者中评估面罩的效用和效率的方法。该项目中生成的初步数据将确认研究设计的可行性，因此，加强了关于在医疗保健环境中为工人既定的感染控制措施有效性的R01提交的提交。