HOWARD UNIVERSITY GENERAL CLINICAL RESEARCH CENTER

霍华德大学普通临床研究中心

• 批准号: 8167000
• 负责人: William Robert Taylor
• 金额: --
• 依托单位: HOWARD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-03-01 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8167000
• 关键词: African American; Anxiety; Caring; Clinical; Clinical Research; Communities; Computer Retrieval of Information on Scientific Projects Database; Exposure to; Funding; Genetic Polymorphism; Grant; Hospitals; Institution; Link; Major Depressive Disorder; Mental Depression; Mental disorders; Patients; Post-Traumatic Stress Disorders; Prevalence; Research; Research Personnel; Resources; Risk; Source; Survivors; Trauma; United States National Institutes of Health; Universities; base; coping; experience

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Description (provided by applicant): Specific Aims: (1) To determine the prevalence of exposure to specific types of traumatic experiences among patients receiving care in a hospital based, primary clinical setting in a predominantly African American community. (2) To determine the prevalence of posttraumatic stress disorder (PTSD) and related psychiatric disorders such as major depression among those who have experienced significant trauma. (3) To identify risk and protective factors that influence which trauma survivors develop posttraumatic stress disorder and/or depression and those who do not. We will specifically evaluate: a. coping strategies and determine whether there are differences in coping styles for trauma survivors that develop PTSD versus those survivors that do not develop PTSD; b. genetic polymorphisms that have been linked to anxiety and depression and determine their associations with the presence or absence of PTSD among those with exposure to severe trauma.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此，可以在其他清晰的条目中表示。列出的机构是 对于中心，这不一定是调查员的机构。 描述（由申请人提供）： 具体目的： （1）确定在医院以非裔美国人社区为基础的主要临床环境中接受护理的患者中暴露于特定类型的创伤经历的患病率。 （2）确定创伤后应激障碍（PTSD）和相关精神疾病的患病率，例如严重创伤的患者。 （3）确定影响创伤幸存者的风险和保护因素，发展了创伤后应激障碍和/或抑郁症以及那些没有的抑郁症。我们将专门评估：应对策略，并确定因创伤幸存者与不发展PTSD的幸存者的应对方式有差异。 b。与焦虑和抑郁有关的遗传多态性，并确定其与暴露于严重创伤的患者之间存在或不存在PTSD的关联。