CLINICAL

临床

• 批准号: 8040956
• 负责人: JOHN MORRIS
• 金额: $ 67.7万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-03-15 至 2013-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8040956
• 关键词: Address; Age; Aging; Alzheimer' s Disease; Anatomy; Autopsy; Behavioral; Biological Markers; Biometry; Biostatistics Core; Blood; Brain; Cerebrospinal Fluid; Cessation of life; Clinic; Clinical; Cognitive; Collection; DNA; Data; Data Set; Dementia; Diagnosis; Elderly; Enrollment; Ensure; Evaluation; Fasting; Genes; Genotype; Goals; Image; Longitudinal Studies; Magnetic Resonance Imaging; Neurologic; Participant; Personality; Plasma; Procedures; Proteins; Protocols documentation; Psychometrics; Recruitment Activity; Registries; Research; Research Infrastructure; Research Personnel; Research Project Grants; Sample Size; Sampling; Schedule; Severities; Staging; Stroke; Third-Party Payer; Time; Variant; Work; aging brain; base; cognitive function; cohort; data management; meetings; neuropathology; post stroke; pre-clinical; programs

Core B: Clinical This Core evaluates and follows all participants entered into the studies of the program project. It uses established clinical and psychometric protocols (including Uniform Data Set assessments) at entry and annually thereafter to obtain clinical, neurological, and behavioral data to carefully characterize each participant, including dementia diagnosis and staging. Clinical Core data are used by all Cores and Projects to explore the correlates of very mild dementia of the Alzheimer type (DAT) in comparison with healthy brain aging. Core B: Clinical recruits and maintains an adequate sample size to supply needed participants for the projects. There is an increased need for nondemented participants as the program project explores AD changes in the brain prior to the occurrence of dementia (preclinical AD). The Core will refer participants to Core E: Imaging to obtain the Common Anatomic Protocol, assess participants in Project 1 ("Preclinical AD predicts poststroke dementia") 1-year poststroke and annually thereafter, obtain blood from all participants for analysis in Project 2 ("Antecedent biomarkers of AD in CSF and plasma") and Project 4 ("Sequence variation in genes for biomarker proteins and age at onset of AD"), and refer participants to Project 2 for CSF collection and to Project 3 ("Markers for DAT: Control, variability, and personality") for study participation. Through its successful voluntary autopsy program the Core provides Core D: Neuropathology with autopsy material for neuropathologic diagnosis. Core B works closely with Core C: Biostatistics to ensure appropriate data management. The Core supports Core A: Administration in promoting scientific interactions among all investigators to accomplish the aims of the program project as a whole.

核心 B：临床 该核心评估并跟踪参与该计划项目研究的所有参与者。它使用 在进入时建立了临床和心理测量协议（包括统一数据集评估） 此后每年获取临床、神经学和行为数据，以仔细表征每个 参与者，包括痴呆症诊断和分期。所有核心和项目都使用临床核心数据 探索极轻度阿尔茨海默型痴呆 (DAT) 与健康大脑的相关性 老化。核心 B：临床招募并维持足够的样本量，以提供所需的参与者 项目。随着该计划项目探索AD，对非痴呆参与者的需求不断增加 痴呆症（临床前 AD）发生之前大脑发生的变化。核心将向参与者推荐 核心 E：成像以获得通用解剖协议，评估项目 1 的参与者（“临床前 AD 预测中风后痴呆症”）中风后一年以及此后每年从所有参与者中采集血液 用于项目 2（“脑脊液和血浆中 AD 的先行生物标志物”）和项目 4（“序列 生物标志物蛋白基因变异和 AD 发病年龄”），并将参与者转介至 CSF 项目 2 收集和项目 3（“DAT 标记：控制、变异性和个性”）用于研究参与。 通过其成功的自愿尸检计划，核心为核心 D：神经病理学提供了 用于神经病理学诊断的尸检材料。核心 B 与核心 C 密切合作：生物统计学，以确保 适当的数据管理。核心支持核心 A：行政管理促进科学发展 所有研究人员之间的互动，以实现整个计划项目的目标。