CORTICAL-SUBCORTICAL INTERACTION IN PARKINSON'S DISEASE AND NORMAL SPEECH

帕金森病和正常言语中的皮质-皮质下相互作用

• 批准号: 8167226
• 负责人: DAVID EIDELBERG
• 金额: $ 0.17万
• 依托单位: FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-04-01 至 2011-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8167226
• 关键词: Address; Area; Bilateral; Brain; Cerebrovascular Circulation; Characteristics; Computer Retrieval of Information on Scientific Projects Database; Deep Brain Stimulation; Functional Imaging; Funding; Goals; Grant; Institution; Measures; Motor; Parkinson Disease; Positron-Emission Tomography; Production; Research; Research Personnel; Resources; Role; Source; Speech; Speech Disorders; Symptoms; Thalamic Nuclei; United States National Institutes of Health; motor control

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The use of deep brain stimulation (DBS) of the sub thalamic nuclei (STN) to treat Parkinson's disease (PD) provides a reversible means of modifying the activity of sub cortical areas. While effective in reducing non speech motor symptoms, this form of therapy often has no effect or even a negative effect on speech, raising questions about the relationship between speech and non speech motor control in PD. Using functional imaging and quantifiable speech production tasks, this project proposes to study the relationships between brain activity in cortical and subcortical regions in subjects with PD, in subjects with PD treated by DBS, and in normal controls. The goal is to better understand cortical subcortical interactions in normal and disordered speech, and the role of such interactions in specific aspects of speech production. Regional cerebral blood flow will be measured during several speech production tasks using positron emission tomography to address four primary specific aims. The first primary specific aim focuses on the relationships between cortical and subcortical areas during speech production in normal subjects. The second primary specific aim focuses on the relationships between cortical and subcortical areas during speech production in PD subjects. The third primary specific aim focuses on the relationships between cortical and subcortical areas during speech production in PD subjects treated with bilateral DBS of the sub-thalamic nuclei. The fourth primary specific aim is to examine and compare the relationships between specific characteristics of speech production and regional cerebral blood flow.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 丘脑亚核（STN）的深脑刺激（DBS）来治疗帕金森氏病（PD）提供了一种可逆的方法来改变皮质下区域的活性。尽管有效减少了非语音运动症状，但这种形式的治疗通常对言语没有影响甚至负面影响，从而提出了有关PD中语音与非语音运动控制之间关系的问题。使用功能成像和可量化的语音生产任务，该项目建议研究患有PD受试者皮质和皮质下区域的脑活动，在由DBS治疗的PD受试者以及正常对照中的PD受试者中。 目的是更好地理解正常和无序言语中皮质下皮层相互作用，以及这种相互作用在语音生产的特定方面的作用。 将在几个语音生产任务中使用正电子发射断层扫描来测量区域脑血流，以解决四个主要特定目的。 第一个主要特定目的侧重于正常受试者语音生产期间皮质和皮层下区域之间的关系。 第二个主要的特定目的侧重于PD受试者语音生产期间皮质和皮层下区域之间的关系。 第三个主要特定目的侧重于用亚丘脑核的双侧DBS治疗的PD受试者的皮质和皮层下区域之间的关系。 第四个主要特定目的是检查和比较语音生产的特定特征与区域脑血流之间的关系。