THE MOLECULAR BASIS FOR COGNITIVE IMPAIRMENT IN PARKINSONS DISEASE: A PET STUDY

帕金森病认知障碍的分子基础：宠物研究

• 批准号: 8167232
• 负责人: ANDREW FEIGIN
• 金额: $ 0.93万
• 依托单位: FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-04-01 至 2011-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8167232
• 关键词: Cognitive deficits; Computer Retrieval of Information on Scientific Projects Database; Deposition; Functional disorder; Funding; Grant; Image; Impaired cognition; Institution; Lewy Bodies; Metabolic; Molecular; Parkinson Disease; Patients; Positron-Emission Tomography; Research; Research Personnel; Resources; Source; Tracer; United States National Institutes of Health; base; novel; protein aggregate

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Cognitive deficits occur in Parkinson's disease (PD) and the cause is currently unknown. We propose a novel study utilizing multi-tracer positron emission tomography imaging to investigate the pathophysiology of cognitive impairment in non-demented PD patients. We hypothesize that aggregated protein deposits associated with Lewy body in the cortical regions may correlate with abnormal metabolic activity and underlie cognitive dysfunction.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 帕金森病 (PD) 会出现认知缺陷，但其原因目前尚不清楚。我们提出了一项利用多示踪剂正电子发射断层扫描成像来研究非痴呆帕金森病患者认知障碍病理生理学的新研究。我们假设，皮质区域中与路易体相关的聚集蛋白沉积可能与异常代谢活动相关，并可能是认知功能障碍的基础。