HIV-1 Infection in Methamphetamine Abusers: Endocrine Outcomes

甲基苯丙胺滥用者的 HIV-1 感染：内分泌结果

• 批准号: 8155014
• 负责人: MAHENDRA KUMAR
• 金额: $ 60.28万
• 依托单位: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-04-01 至 2016-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8155014
• 关键词: Acquired Immunodeficiency Syndrome; Address; Adrenal Glands; African American; Antibodies; CRH gene; Caucasians; Caucasoid Race; Cocaine; Cocaine Abuse; Comorbidity; Contracts; Corticotropin; Country; Cytokine Gene; Dexamethasone; Drug abuse; Endocrine; Endocrine system; Euphoria; Florida; Gene Expression; Glucose; HIV; HIV-1; Hispanics; Hydrocortisone; Hyperglycemia; Hyperthyroidism; Illicit Drugs; Incidence; Individual; Infection; Inflammatory; Insulin; Insulin Resistance; Intervention; Investigation; Iodide Peroxidase; Lead; Medical; Methamphetamine; Opioid; Outcome; Oxidative Stress; Participant; Pharmaceutical Preparations; Population; Reporting; Risk Factors; Rodent; Syndrome; Testing; Thyroid Gland; Time; United States; adverse outcome; drug abuser; insulin secretion; men; men who have sex with men; methamphetamine abuse; response; therapy design

DESCRIPTION (provided by applicant): HIV-1 Infection is associated with adverse outcomes in endocrine systems. Illicit drug abuse is a major risk factor for contracting HIV-1 infection and is also associated with abnormal endocrine outcomes. Several studies including ours have reported exacerbated endocrine abnormalities among drug abusing HIV-1+ individuals. But these investigations have been carried out among cocaine and/or opioids addicts, and the culture of drug abuse in the United States is changing. Methamphetamine (meth) is becoming a drug of choice all over the country and its abuse in South Florida particularly among MSM has skyrocketed. There is, however, a scarcity of investigations on the impact of methamphetamine on endocrines in HIV-1 infection. It is hypothesized that adrenal activity will be increased, there will be a hyper activity of thyroid as well as an increased incidence of insulin resistance, among HIV-1+ meth abusing MSM. In order to test these hypotheses, this 5 year application proposes to investigate cross sectionally adrenal, thyroid, and insulin activity in a total of 450 men in three groups: HIV-1+ meth abusers (n=150), HIV-1- meth abusers (n=150), HIV-1 - non-meth abusers (n=150) distributed among African Americans, Caucasians, and Hispanics. Because of the planned focus on MSM, only men will be included in the study. The following are aims: Aim 1: To investigate adrenal activity (ACTH and cortisol levels) as well as response to the combined dexamethasone-CRH challenge among meth abusing-HIV-1+ MSM, meth abusing HIV-1- MSM and HIV-1- meth-free control participants. Aim 2: To investigate thyroid activity (TSH, T4 and T3) as well as thyroid antibodies among meth abusing-HIV-1+ MSM, meth abusing HIV-1- MSM and HIV-1- meth-free control participants. Aim 3: To explore insulin activity among meth abusing-HIV-1+ MSM; meth abusing HIV-1- MSM and HIV-1- meth-free control participants. These endocrine disturbances may lead to enormous burden of a number of serious medical consequences and outcomes in meth abusing MSM and further allow developing suitable interventions. PUBLIC HEALTH RELEVANCE: Methamphetamine (meth) abuse particularly among MSM in South Florida has skyrocketed. Although endocrine outcomes in HIV-1 infection as well as drug abusers with HIV- 1 infection have been investigated, there is scarcity of information regarding such outcomes in HIV-1+ meth abusing MSM. This proposal investigates adrenal, thyroid and insulin activities in this population. It is proposed that adverse endocrine outcomes may result in an enormous medical burden.

描述（由申请人提供）：HIV-1感染与内分泌系统中的不良结果有关。非法药物滥用是感染HIV-1感染的主要危险因素，也与内分泌异常结局有关。包括我们的几项研究报告了滥用HIV-1+个体的药物中内分泌异常加剧。但是，这些调查是在可卡因和/或阿片类药物上瘾者之间进行的，美国的药物滥用文化正在发生变化。甲基苯丙胺（甲基苯丙胺（Meth））正成为全国各地的一种首选药物，在南佛罗里达州，尤其是在MSM中，甲基苯丙胺（METH）猛增。但是，关于甲基苯丙胺对HIV-1感染中内分泌的影响的研究很少。假设肾上腺活性将增加，在滥用HIV-1+ MECH的MSM中，甲状腺的活性将有超级活性以及胰岛素抵抗的发生率增加。为了检验这些假设，本五年的申请提议在三组中总共450名男性中研究横截面肾上腺，甲状腺和胰岛素活性：HIV-1+甲基甲基苯甲酸甲酯（n = 150），HIV-1- MECH施虐者（n = 150），HIV-1-非麦芽虐待者（n = 150）分布在非洲裔美国人，高加索人和西班牙裔中。由于计划对MSM的关注，因此只有男性将包括在研究中。以下目的是：目的1：研究肾上腺活性（ACTH和皮质醇水平），以及对滥用甲基甲基甲基甲基甲烷的HIV-1+ MSM中对地塞米松-CRH挑战的响应，滥用HIV-1-MSM和HIV-1- - 无甲基对照参与者。目标2：研究甲状腺活性（TSH，T4和T3）以及滥用甲基甲基甲基甲基甲状腺抗体，滥用HIV-1+ MSM，滥用HIV-1-MSM和HIV-1-无HIV-1-无用的对照参与者。目的3：探索滥用甲基甲基甲基-HIV-1+ MSM之间的胰岛素活性；滥用HIV-1-MSM和HIV-1-无甲基对照参与者。 这些内分泌障碍可能会导致许多严重的医疗后果和滥用MSM的甲基甲基苯丙胺结果的巨大负担，并进一步制定合适的干预措施。 公共卫生相关性：甲基苯丙胺（甲基苯丙胺）滥用，尤其是在南佛罗里达州的MSM中，已经猛增了。尽管已经研究了HIV-1感染中的内分泌结局以及HIV-1感染的药物，但有关HIV-1+滥用MSM的此类结果的信息稀缺。该提案调查了该人群中的肾上腺，甲状腺和胰岛素活动。有人提出，不良内分泌结果可能会导致巨大的医疗负担。