HIV-1 Infection in Methamphetamine Abusers: Endocrine Outcomes

甲基苯丙胺滥用者的 HIV-1 感染：内分泌结果

• 批准号: 8603232
• 负责人: MAHENDRA KUMAR
• 金额: $ 59.49万
• 依托单位: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-04-01 至 2016-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8603232
• 关键词: Acquired Immunodeficiency Syndrome; Address; Adrenal Glands; African American; Antibodies; CRH gene; Caucasians; Caucasoid Race; Cocaine; Cocaine Abuse; Comorbidity; Contracts; Corticotropin; Country; Cytokine Gene; Dexamethasone; Drug abuse; Endocrine; Endocrine system; Euphoria; Florida; Gene Expression; Glucose; HIV; HIV-1; Hispanics; Hydrocortisone; Hyperglycemia; Hyperthyroidism; Illicit Drugs; Incidence; Individual; Infection; Inflammatory; Insulin; Insulin Resistance; Intervention; Investigation; Iodide Peroxidase; Lead; Medical; Methamphetamine; Opioid; Outcome; Oxidative Stress; Participant; Pharmaceutical Preparations; Population; Reporting; Risk Factors; Rodent; Syndrome; Testing; Thyroid Gland; Time; United States; adverse outcome; drug abuser; insulin secretion; men; men who have sex with men; methamphetamine abuse; public health relevance; response; therapy design

DESCRIPTION (provided by applicant): HIV-1 Infection is associated with adverse outcomes in endocrine systems. Illicit drug abuse is a major risk factor for contracting HIV-1 infection and is also associated with abnormal endocrine outcomes. Several studies including ours have reported exacerbated endocrine abnormalities among drug abusing HIV-1+ individuals. But these investigations have been carried out among cocaine and/or opioids addicts, and the culture of drug abuse in the United States is changing. Methamphetamine (meth) is becoming a drug of choice all over the country and its abuse in South Florida particularly among MSM has skyrocketed. There is, however, a scarcity of investigations on the impact of methamphetamine on endocrines in HIV-1 infection. It is hypothesized that adrenal activity will be increased, there will be a hyper activity of thyroid as well as an increased incidence of insulin resistance, among HIV-1+ meth abusing MSM. In order to test these hypotheses, this 5 year application proposes to investigate cross sectionally adrenal, thyroid, and insulin activity in a total of 450 men in three groups: HIV-1+ meth abusers (n=150), HIV-1- meth abusers (n=150), HIV-1 - non-meth abusers (n=150) distributed among African Americans, Caucasians, and Hispanics. Because of the planned focus on MSM, only men will be included in the study. The following are aims: Aim 1: To investigate adrenal activity (ACTH and cortisol levels) as well as response to the combined dexamethasone-CRH challenge among meth abusing-HIV-1+ MSM, meth abusing HIV-1- MSM and HIV-1- meth-free control participants. Aim 2: To investigate thyroid activity (TSH, T4 and T3) as well as thyroid antibodies among meth abusing-HIV-1+ MSM, meth abusing HIV-1- MSM and HIV-1- meth-free control participants. Aim 3: To explore insulin activity among meth abusing-HIV-1+ MSM; meth abusing HIV-1- MSM and HIV-1- meth-free control participants. These endocrine disturbances may lead to enormous burden of a number of serious medical consequences and outcomes in meth abusing MSM and further allow developing suitable interventions.

描述（由申请人提供）：HIV-1 感染与内分泌系统的不良后果相关。非法药物滥用是感染 HIV-1 的主要危险因素，也与内分泌结果异常有关。包括我们在内的几项研究报告了吸毒 HIV-1+ 个体的内分泌异常加剧。但这些调查是在可卡因和/或阿片类药物成瘾者中进行的，美国的药物滥用文化正在发生变化。甲基苯丙胺 (meth) 正在成为全国范围内的首选药物，在南佛罗里达州，尤其是男男性接触者中的滥用情况急剧上升。然而，关于甲基苯丙胺对 HIV-1 感染者内分泌的影响的研究却很少。据推测，在 HIV-1+ 滥用甲基苯丙胺的 MSM 中，肾上腺活性会增加，甲状腺活性会升高，胰岛素抵抗的发生率也会增加。为了检验这些假设，这项为期 5 年的申请计划对总共 450 名男性的肾上腺、甲状腺和胰岛素活性进行横断面调查，分为三组：HIV-1+ 冰毒滥用者 (n=150)、HIV-1- 冰毒滥用者滥用者 (n=150)、HIV-1 - 非冰毒滥用者 (n=150) 分布在非裔美国人、白人和西班牙裔中。由于计划重点关注 MSM，因此该研究仅包括男性。目标如下： 目标 1：调查甲基滥用-HIV-1+ MSM、甲基滥用 HIV-1- MSM 和 HIV-1 之间的肾上腺活动（ACTH 和皮质醇水平）以及对地塞米松-CRH 联合挑战的反应- 不含冰毒的对照参与者。目标 2：调查甲基滥用 HIV-1+ MSM、甲基滥用 HIV-1- MSM 和 HIV-1- 无甲基对照参与者的甲状腺活性（TSH、T4 和 T3）以及甲状腺抗体。目标 3：探讨甲基滥用 HIV-1+ MSM 中的胰岛素活性；滥用 HIV-1-MSM 和 HIV-1-无冰毒对照参与者。 这些内分泌紊乱可能会给滥用甲基苯丙胺的男男性接触者带来许多严重的医疗后果和结果的巨大负担，并进一步允许制定适当的干预措施。