Biomechanical Measurement and Modeling of Normal and Diseased Middle Ears

正常和患病中耳的生物力学测量和建模

• 批准号: 8088449
• 负责人: RONG Z GAN
• 金额: $ 35.17万
• 依托单位: UNIVERSITY OF OKLAHOMA
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2016-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8088449
• 关键词: 3-Dimensional; Acoustics; Age; Air; Anatomic structures; Articular ligaments; Auditory; Automobile Driving; Behavior; Biomechanics; Cells; Child; Childhood; Chinchilla (genus); Clinical; Communicable Diseases; Computer Simulation; Conductive hearing loss; Coupled; Data; Development; Diagnosis; Diagnostic tests; Disease; Ear; Elements; Eustachian Tube; Frequencies; Functional disorder; Goals; Hearing; Holography; Human; Individual; Infection; Inflammatory; Joints; Lasers; Liquid substance; Mastoid process; Measurement; Measures; Mechanics; Membrane; Methods; Modeling; Morphology; Muscle function; Names; Otitis Media; Otitis Media with Effusion; Otoscopy; Patients; Permeability; Physicians; Physiological; Play; Property; Research; Research Project Grants; Role; Series; Structure; Structure-Activity Relationship; System; Techniques; Test Result; Testing; Thick; Tissue Model; Tissues; Tympanic membrane; Tympanometry; Variant; Viscosity; acoustic reflex; base; bone; clinical application; clinically relevant; effusion; hearing impairment; human tissue; improved; middle ear; middle ear disorder; novel; pathogen; pressure; response; round window; soft tissue; sound; stapedius muscle; tool; transmission process; vibration

DESCRIPTION (provided by applicant): The middle ear, composed of ossicles and soft tissues including the tympanic membrane, ligaments, and joints plays a vital role in the transmission of sound and the sense of hearing. The mechanical properties of soft tissues change in middle ear diseases such as otitis media. As a consequence, the mobility of ossicular chain is reduced and significant conductive hearing loss occurs in otitis media ears. However, the mechanical property changes in soft tissue associated with disease are largely unstudied. It is almost impossible to identify mechanical changes of middle ear tissues in relation to hearing loss based on current clinical tools. The goal of this project is to characterize the biomechanical behaviors of soft tissues in normal and diseased ears, identify soft tissue changes which are associated with changes in normal hearing, and provide an improved 3-dimensional (3D) ear model to visualize and quantify structure-function relations in various diseases. Otitis media (OM) will be the primary focus for the project. Three specific aims are proposed: Aim 1: To Identify changes of mechanical properties of middle ear soft tissue in OM. We hypothesize that the change of mechanical properties of ear tissues in OM is related to morphological changes of the tissue in response to fluid, pressure, and duration of the OM. This hypothesis will be tested by comparison of measurement results of the ear tissues between normal and diseased ears in chinchillas using dynamic mechanical analyzer, split Hopkinson tension bar, acoustic driving with laser Doppler vibrometry (LDV), fringe Moiri system, and FE modeling of soft tissue. Aim 2: To quantify the effect of biomechanical changes of the middle ear on sound transmission in OM. It is hypothesized that the hearing loss in OM is caused by a combination of changes of ear tissues, fluid, and pressure in the middle ear. This hypothesis will be tested by measuring the ABR thresholds and the changes of middle ear transfer function and sound energy transmission in chinchilla OM ears with a novel theoretical analysis of fluid, pressure, and tissue properties with the aid of FE model of chinchilla ear to describe the mechanism of OM. Aim 3: To continue the development of our 3D FE model of the human ear with clinically-relevant applications. We will incorporate into the model with tissue properties determined in Aims 1 and 2, the microstructures of the TM and ISJ, and the stapedius muscle function. A FE model of pediatric ear will be created for studying OM in young children. The acoustic-mechanical vibration and energy transmission through the middle ear in diseased ears will be visualized and quantified in the 3D FE model by 4 novel model-derived "auditory test curves", named as: the middle ear transfer function (METF), energy absorbance (EA), admittance tympanogram (AT), and TM holography, which will assist physicians and audiologists to interpret the diagnostic test results and identify the specific type of middle ear disorders. PUBLIC HEALTH RELEVANCE: Middle ear diseases often result in conductive hearing loss due to the changes of middle ear structure and soft tissue properties caused by the diseases. Understanding the relationship between the middle ear structural change and function of the middle ear will help diagnosis of different middle ear diseases. The proposed research project is to determine mechanical property changes in ear tissues associated with middle ear diseases and provide a computational model of the human ear to visualize and quantify structure-function relations in various diseases.

描述（由申请人提供）：中耳，由耳膜和软组织组成，包括鼓膜膜，韧带和关节在声音的传播和听力感中起着至关重要的作用。软组织的机械性能在中耳疾病（例如中耳炎）中发生了变化。结果，骨骼链的迁移率降低了，并且在中耳炎培养基耳朵中发生了明显的导电性听力损失。然而，与疾病相关的软组织的机械性能变化在很大程度上没有研究。基于当前的临床工具，几乎不可能确定与听力损失有关的中耳组织的机械变化。 该项目的目的是表征正常耳朵和患病的软组织的生物力学行为，确定与正常听力变化相关的软组织变化，并提供改进的3维（3D）耳模型，以可视化和量化各种疾病中的结构功能关系。中耳炎（OM）将是该项目的主要重点。提出了三个特定的目标：目标1：确定中耳软组织机械性能的变化。我们假设OM中耳组织的机械性能的变化与OM的液体，压力和持续时间响应组织的形态变化有关。该假设将通过使用动态机械分析仪，霍普金森张力分裂，用激光多普勒多普勒振动法（LDV），边缘Moiri系统和软组织的FE模型进行比较，通过比较龙猫的正常耳朵和患病耳朵之间耳朵组织的测量结果。目标2：量化中耳生物力学变化对OM中声传输的影响。假设OM的听力损失是由中耳组织，流体和压力变化的组合引起的。该假设将通过测量ABR阈值以及中耳转移功能和龙猫OM耳的中等声音传递的变化，并借助Chinchilla Ear的Fe模型对流体，压力和组织性能进行新的理论分析，以描述OM的机制。目标3：继续使用与临床相关的应用开发我们的3D FE模型。我们将通过在目标1和2（TM和ISJ的微观结构）以及stapedius肌肉功能中确定的组织特性并入模型中。将创建一种用于研究幼儿OM的小儿耳朵的模型。 The acoustic-mechanical vibration and energy transmission through the middle ear in diseased ears will be visualized and quantified in the 3D FE model by 4 novel model-derived "auditory test curves", named as: the middle ear transfer function (METF), energy absorbance (EA), admittance tympanogram (AT), and TM holography, which will assist physicians and audiologists to interpret the diagnostic test results and identify the specific type of中耳障碍。 公共卫生相关性：中耳疾病通常会导致导电性听力损失，这是由于中耳结构的变化和疾病引起的软组织特性的变化。了解中耳结构变化与中耳功能之间的关系将有助于诊断不同的中耳疾病。拟议的研究项目旨在确定与中耳疾病相关的耳朵组织的机械性能变化，并提供人耳朵的计算模型，以可视化和量化各种疾病中的结构 - 功能关系。