Ear Biomechanics for Restoration of Hearing

恢复听力的耳生物力学

基本信息

批准号：
7448578
负责人：
RONG Z GAN
金额：
$ 21.8万
依托单位：
UNIVERSITY OF OKLAHOMA
依托单位国家：
美国
项目类别：
财政年份：
2005
资助国家：
美国
起止时间：
2005-07-15 至 2010-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7448578
关键词：
3-Dimensional Acoustics Affect Anatomic structures Articular ligaments Behavior Biomechanics Biomedical Engineering Characteristics Clinical Cochlea Computer Simulation Conductive hearing loss Coupled Data Diagnosis Diagnostic Diagnostic Procedure Ear Effectiveness Elements Engineering Eustachian Tube Excision External Ear External auditory canal Finite Element Analysis Functional disorder Goals Hearing Human Image Image Analysis Interferometry Labyrinth Lasers Ligaments Liquid substance Materials Testing Measurement Measures Mechanics Methodology Modeling Necrosis Operative Surgical Procedures Otitis Media with Effusion Output Pathologic Pathology Pattern Photography Physiological Property Quality of life Research Personnel Simulate Speed Stapes Structure Surgical Disarticulation System Techniques Temporal bone structure Testing Three-dimensional analysis Tissues Tympanic membrane Tympanometry Work base clinical application digital imaging electric impedance improved middle ear middle ear disorder morphometry nanoindentation programs reconstruction research study restoration sample fixation sound tool transmission process vibration viscoelasticity

项目摘要

DESCRIPTION (provided by applicant): The long-term goal of this project is to determine how the structure and mechanical properties of human ear affect acoustic-mechanical transmission through the external ear canal and middle ear to inner ear (or cochlea) in normal, pathological and reconstructed ears. Our hypothesis is that incorporation of our 3-D comprehensive FE model of the human ear into clinical tympanometry, a diagnostic tool commonly used on middle ear diseases, and laser Doppler interferometry, a potential clinical tool for diagnosis of conductive hearing loss, can improve the diagnosis of otitis media with effusion (OME). There are four specific aims proposed here: (1) to identify how alterations in middle ear structures affect sound transmission from the ear canal through the middle ear to the cochlea measured with laser interferometry and tympanometry; (2) to measure mechanical properties or viscoelasticity of middle ear tissues such as the ligaments and tympanic membrane; (3) to develop multi-field (i.e., acoustic-structure-fluid) coupled analysis of the 3-D FE model with structural alterations in middle ear on human temporal bones; and (4) To correlate our 3-D FE model results with clinical measurements obtained by tympanometry and laser interferometry for improvement of the diagnosis of middle ear diseases such as OME. Four unique approaches are incorporated in the project: (a) accurate geometric reconstruction of entire human ear based on histological images of temporal bone morphometry; (b) direct, accurate measurement of viscoelastic properties of middle ear tissues using the nanoindentation system and digital image correlation techniques; (c) improved human temporal bone experiment with dual laser Doppler interferometry system to measure simultaneously the acoustic-mechanical conduction through the middle ear; and (d) coupled acoustic-structure-fluid analysis of sound transmission from the ear canal to middle ear, and to the cochlea. Experiments described in this proposal will show how changes in middle ear structure and cochlear load affect the sound transmission in the ear. The FE model will demonstrate the potential clinical applications on how the middle ear fluid, ligament cut or removal, and ossicular disarticulation, fixation, or necrosis affect the middle ear transfer function. Thus, the results will be essential for improving the diagnosis of OME, assessing surgical treatment for conductive hearing loss, and potentially improve the quality of life for millions of people.

描述（由申请人提供）：该项目的长期目标是确定人耳的结构和机械特性如何影响正常情况下通过外耳道和中耳到内耳（或耳蜗）的声学机械传输，病理性和重建的耳朵。我们的假设是，将我们的人耳 3-D 综合 FE 模型纳入临床鼓室测量（一种常用于中耳疾病的诊断工具）和激光多普勒干涉测量（一种用于诊断传导性听力损失的潜在临床工具）中，可以改善听力损失的听力损失。诊断为渗出性中耳炎（OME）。这里提出了四个具体目标：（1）确定中耳结构的改变如何影响通过激光干涉测量和鼓室导抗测量测量的从耳道通过中耳到耳蜗的声音传输； (2)测量韧带、鼓膜等中耳组织的力学性能或粘弹性； (3) 开发人类颞骨中耳结构改变的 3-D 有限元模型的多场（即声学-结构-流体）耦合分析； (4) 将我们的 3-D FE 模型结果与通过鼓室导抗测试和激光干涉测量获得的临床测量结果关联起来，以改善 OME 等中耳疾病的诊断。该项目采用了四种独特的方法：（a）基于颞骨形态测量的组织学图像对整个人耳进行精确的几何重建； (b) 使用纳米压痕系统和数字图像相关技术直接、准确地测量中耳组织的粘弹性； (c) 使用双激光多普勒干涉测量系统改进人体颞骨实验，以同时测量通过中耳的声机械传导； (d)从耳道到中耳再到耳蜗的声音传输的声学结构流体耦合分析。该提案中描述的实验将展示中耳结构和耳蜗负载的变化如何影响耳朵中的声音传输。有限元模型将展示中耳积液、韧带切断或去除以及听小骨离断、固定或坏死如何影响中耳传递功能的潜在临床应用。因此，这些结果对于改善 OME 的诊断、评估传导性听力损失的手术治疗以及潜在改善数百万人的生活质量至关重要。