Neurovascular Plasticity

神经血管可塑性

• 批准号: 8040323
• 负责人: RON D FROSTIG
• 金额: $ 43.86万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-15 至 2015-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8040323
• 关键词: Adult; Adverse effects; Animal Model; Area; Arteries; Astrocytes; Behavioral; Behavioral Assay; Blood Vessels; Blood flow; Brain; Brain Injuries; Cerebral cortex; Elderly; Electric Stimulation; Electrodes; Face; Functional Imaging; Future; Goals; Histology; Hour; Human; Image; Injury; Ischemia; Ischemic Brain Injury; Laboratories; Lead; Learning; Ligation; Maps; Mechanical Stimulation; Memory; Metabolic; Metabolism; Methods; Modeling; Neuronal Plasticity; Neurons; Neurosciences Research; Pathway interactions; Pattern; Physical therapy; Plastics; Population; Process; Rattus; Recovery; Rehabilitation therapy; Reperfusion Therapy; Research; Resolution; Role; Somatosensory Cortex; Stimulus; Stroke; Structure; Study models; Synapses; System; Techniques; Time; Vascular System; Vascular blood supply; Vibrissae; aged; barrel cortex; base; conventional therapy; design; injured; interest; middle cerebral artery; nervous system disorder; public health relevance; research study; sensory cortex; young adult

DESCRIPTION (provided by applicant): For the last 30 years, there has been a growing recognition that adult plasticity is a fundamental mechanism underlying a host of brain processes ranging from recovery after injury to learning and memory and involves multiple levels of the brain including synapses, neurons, neuronal circuits, representational maps, and even supporting metabolic and vascular systems. Enhancement of neuronal plasticity as a means of treatment of neurological disorders and injuries has not been fully utilized, although such treatments are an attractive alternative to more conventional treatments because they have few, if any, side effects. Could plasticity be exploited for protection from brain injury? We propose the hypothesis that one type of plasticity, neurovascular plasticity, could be exploited to completely protect the cortex from ischemic injury. The proposed multifaceted study is designed for detailed quantification to further answer specific hypotheses related to protection by neurovascular plasticity and its underlying mechanisms at the functional, metabolic, histological, vascular, and behavioral levels in both adult and old rats. PUBLIC HEALTH RELEVANCE: The brain, and especially the cortex, is plastic (i.e., mutable) as demonstrated for many brain processes ranging from recovery from injury to learning and memory. Could plasticity be further exploited to protect it from brain injury? Based on new findings from our laboratory, we propose the hypothesis that one type of plasticity, neurovascular plasticity, could indeed be exploited to completely protect the ischemic injury (stroke) in adult and old rats.

描述（由申请人提供）：在过去的30年中，人们越来越认识到成人可塑性是一种基本机制，其基本机制是大脑过程的基础，从受伤后的恢复到学习和记忆，涉及多个大脑，包括突触，神经元，神经元，神经元电路，代表性图，什至支持代谢和血管质体系。神经元可塑性作为神经系统疾病和损伤的治疗方法的增强尚未得到充分利用，尽管这种治疗是对更常规治疗的有吸引力的替代方法，因为它们几乎没有副作用（如果有的话）。可以利用可塑性以防止脑损伤吗？我们提出这样的假设，即可以利用一种可塑性，神经血管可塑性，以完全保护皮质免受缺血性损伤。拟议的多方面研究旨在详细量化，以进一步回答与神经血管可塑性及其在成人和老大鼠中功能，代谢，组织学，血管和行为水平的基本机制相关的特定假设。 公共卫生相关性：大脑，尤其是皮层，是塑料的（即可变的），如许多大脑过程所证明的，从损伤到学习和记忆。可以进一步利用可塑性以保护其免受脑损伤吗？根据我们实验室的新发现，我们提出了这样一种假设，即确实可以利用一种类型的可塑性，神经血管可塑性，以完全保护成人和老鼠的缺血性损伤（中风）。