Electrochemical Home Monitoring System for Lithium Blood Level

家用电化学锂血浓度监测系统

• 批准号: 7893481
• 负责人: LINDA A TEMPELMAN
• 金额: $ 17.47万
• 依托单位: GINER, INC.
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-04-01 至 2011-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7893481
• 关键词: Acquired Immunodeficiency Syndrome; Acute; Address; Adsorption; Adult; Affect; Algorithms; Bipolar Disorder; Blood; Blood Tests; Blood specimen; Boron; Caregivers; Characteristics; Chronic; Clinic; Clinical; Collaborations; Combined Modality Therapy; Communication; Communities; Complex; Computer software; Computers; Data; Detection; Development; Diagnosis; Diamond; Disadvantaged; Disease; Effectiveness; Electrodes; Electrolytes; Ensure; Environment; Evaluation; Feasibility Studies; Fingers; Future; General Hospitals; Goals; Hand; Health; Health Care Costs; Health behavior; Healthcare; Home environment; Hospitalization; Individual; Instruction; Ions; Laboratories; Lithium; Lithium Carbonate; Maintenance; Manic; Manic Disorder; Massachusetts; Measurement; Measures; Medical; Mental Health; Methods; Microelectrodes; Microfluidics; Monitor; Mood Disorders; National Institute of Mental Health; Notification; Office Visits; Patients; Performance; Pharmacological Treatment; Pharmacotherapy; Phase; Physicians; Physicians' Offices; Physiologic pulse; Price; Process; Production; Quality of life; Recording of previous events; Reporting; Research; Role; Sampling; Scheme; Serum; Signal Transduction; Simulate; Small Business Innovation Research Grant; Solutions; Solvents; Spectrometry; System; Systems Analysis; Techniques; Technology; Testing; Therapeutic; Therapeutic Uses; Time; Work; analog; aqueous; base; catalyst; computerized data processing; cost; design; discount; effective therapy; experience; glucose monitor; graphical user interface; improved; innovation; instrument; instrumentation; medical specialties; meetings; operation; product development; programs; prototype; public health relevance; research and development; research clinical testing; response; sensor; technology development; user-friendly

DESCRIPTION (provided by applicant): Electrochemical Home Monitoring System for Lithium Blood Level Lithium in the form of lithium carbonate is an important pharmacological treatment option in bipolar disorder and other conditions. However, lithium has a narrow therapeutic treatment range and its use requires careful monitoring of a patient's lithium blood level, particularly during the initiation of treatment. Current monitoring techniques are inconvenient and costly, requiring a clinical analytical laboratory. There is no commercially- available system for home measurement of blood lithium. This program will develop an advanced, rapid, and convenient home system which could make a significant impact in the health of those individuals being treated with lithium and encourage full therapeutic use of lithium when the medical condition merits. The innovation in the proposed work is to develop an electrochemical sensor comprised of a high performance microelectrode combined with a sensitive and selective electroanalytical technique in a predominantly nonaqueous electrochemical environment to measure lithium concentration in the clinically important range (0.2 - 3.0 millimoles per liter) from (aqueous) blood samples. Giner, Inc. will expand on its preliminary data on lithium detection and utilize its experience with the proposed electrochemical techniques and electrode materials. A major advantage of the proposed technology is that electrochemical techniques can be packaged into instruments for automated operation in the home which makes them very inexpensive and convenient compared to other laboratory-based analytical techniques. The final product will have the ease-of-use of a home glucose monitor and provide the clinician with real-time lithium measurements needed for optimal and cost-effective treatment of the patient. While there are multiple pharmacotherapy treatments for bipolar disorder, approximately 20% of the 5.7 million diagnosed patients in the U.S. use lithium as part of their treatment. The proposed product could be used in the home by the patient and also by the clinician during office visits. PUBLIC HEALTH RELEVANCE: The overall goal of this SBIR research and development program is the development of a home-based monitoring system for blood lithium for patient's use. The lithium blood level is very critical; therefore, bipolar disorder patients are now required to have frequent laboratory blood tests. A home-based system would provide convenience for patients while improving treatment and decreasing health care costs.

描述（由申请人提供）： 碳酸锂形式的锂血液水平锂的电化学家居监测系统是躁郁症和其他疾病的重要药理治疗选择。但是，锂的治疗范围狭窄，其使用需要仔细监测患者的锂血液水平，尤其是在开始治疗期间。当前的监测技术不方便且昂贵，需要临床分析实验室。没有可用于血液锂家庭测量的商业可用系统。该计划将开发出高级，快速且方便的家庭系统，这可能会对那些接受锂治疗的人的健康产生重大影响，并在医疗状况值得的情况下鼓励对锂的全面使用。拟议工作的创新是开发由高性能微电极组成的电化学传感器，并在主要非水的电化学环境中结合了一种敏感和选择性的电分析技术，以测量临床上重要范围的锂浓度（每位0.2-3.0毫米）（0.2-3.0毫升） （水）血液样本。 Giner，Inc。将扩展其有关锂检测的初步数据，并利用其建议的电化学技术和电极材料的经验。该技术的一个主要优点是，电化学技术可以包装到家庭中的自动操作仪器中，这使其与其他基于实验室的分析技术相比非常便宜且方便。最终产品将易于使用家用葡萄糖监测器，并为临床医生提供最佳和具有成本效益的患者治疗所需的实时锂测量。尽管对躁郁症进行了多种药物治疗，但美国570万诊断出患者中约有20％使用锂作为治疗的一部分。拟议的产品可以在办公室访问期间由患者和临床医生在家里使用。 公共卫生相关性： 该SBIR研发计划的总体目标是开发基于家庭的血液锂的监测系统，以供患者使用。锂血液水平非常关键。因此，躁郁症患者现在需要进行频繁的实验室血液检查。基于家庭的系统将为患者提供便利，同时改善治疗并降低医疗保健费用。