Cross-talk between iron metabolism and intestinal inflammation

铁代谢与肠道炎症之间的串扰

• 批准号: 8077697
• 负责人: Bobby Joseph Cherayil
• 金额: $ 43.64万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-06-21 至 2012-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8077697
• 关键词: Address; Anemia; Animals; Anti-Inflammatory Agents; Anti-inflammatory; Antibodies; Attenuated; BMP6 gene; Blood Circulation; Bone Morphogenetic Proteins; Cells; Chronic; Colitis; Complex; Deposition; Development; Disease; Dominant-Negative Mutation; Down-Regulation; Endocytosis; Enterocolitis; Enterocytes; Exposure to; Foundations; Gram-Negative Bacteria; Hemochromatosis; Hepatocyte; Homeostasis; Human; Immune response; Impairment; In Vitro; Individual; Inflammation; Inflammation Mediators; Inflammatory; Inflammatory Bowel Diseases; Inflammatory Response; Inflammatory disease of the intestine; Interleukin-10; Interleukin-6; Investigation; Iron; Iron Metabolism Disorders; Iron Overload; Knock-out; Knockout Mice; Lead; Mediating; Metals; Modeling; Mouse Strains; Pathogenesis; Pathway interactions; Peptides; Piroxicam; Process; Production; Protein Export Pathway; Reagent; Role; Salmonella; Secondary to; Serum; Severities; Signal Transduction; TLR4 gene; Testing; Tissues; Up-Regulation; Wild Type Mouse; base; cytokine; hepcidin; in vivo; iron metabolism; macrophage; metal transporting protein 1; mouse model; novel; novel strategies; protein expression; research study; response; toll-like receptor 4

项目成果

The role of iron in the immune response to bacterial infection.

• DOI: 10.1007/s12026-010-8199-1
• 发表时间: 2011-05
• 期刊: IMMUNOLOGIC RESEARCH
• 影响因子: 4.4
• 作者: Cherayil, Bobby J.

Iron and intestinal immunity.

• DOI: 10.1097/mog.0b013e32834a4cd1
• 发表时间: 2011-10
• 期刊: Current opinion in gastroenterology
• 影响因子: 2.5
• 作者: Cherayil BJ;Ellenbogen S;Shanmugam NN
• 通讯作者: Shanmugam NN

Iron and immunity: immunological consequences of iron deficiency and overload.

• DOI: 10.1007/s00005-010-0095-9
• 发表时间: 2010-12
• 期刊: ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS
• 影响因子: 3.2
• 作者: Cherayil, Bobby J.