KLF10 regulates colitis through mediating TGFb induction of FOXP3 in Treg cells.

KLF10 通过介导 Treg 细胞中 TGFb 诱导 FOXP3 来调节结肠炎。

• 批准号: 8123620
• 负责人: William A Faubion
• 金额: $ 39.43万
• 依托单位: MAYO CLINIC ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-18 至 2011-02-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8123620
• 关键词: Address; Adoptive Transfer; Affect; Antigens; Area; Autoimmune Diseases; Binding; Biology; Cancer Prognosis; Cell Line; Cells; Chromatin; Chronic; Clinic; Colitis; Colorectal Cancer; Crohn' s disease; DNA; Data; Development; Diabetes Mellitus; Disease; Environment; Enzymes; Epigenetic Process; Equilibrium; Event; Experimental Designs; Experimental Models; Family; Family member; Gene Activation; Gene Expression; Gene Expression Regulation; Gene Targeting; Generations; Genes; Genetic Transcription; Genome; Genomics; Goals; Histone Acetylation; Histones; Human; Human Cell Line; Immune; Immune response; Immunology; Inflammation; Inflammatory; Inflammatory Bowel Diseases; Intestines; Laboratories; Luciferases; Malignant Neoplasms; Mediating; Methodology; Mus; Neoplasms; Pathogenesis; Pathway interactions; Predisposition; Prevalence; Process; Protein Family; Proteins; Public Health; Qualifying; Recruitment Activity; Regulation; Regulatory Pathway; Regulatory T-Lymphocyte; Reporter; Research Personnel; Rheumatoid Arthritis; Role; Severities; System; T-Lymphocyte; T-Lymphocyte Subsets; Testing; Therapeutic; Transfection; Transgenic Animals; Transgenic Organisms; Work; Zinc Fingers; base; body system; cell type; chromatin modification; chromatin remodeling; cytokine; design; experience; lifetime risk; member; novel; prevent; programs; promoter; public health relevance; resistance mechanism; transcription factor