Treating Stimulant Addiction with Repetitive Transcranial Magnetic Stimulation

通过重复经颅磁刺激治疗兴奋剂成瘾

基本信息

批准号：
10013791
负责人：
JONG H YOON
金额：
--
依托单位：
VETERANS ADMIN PALO ALTO HEALTH CARE SYS
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-09-01 至 2022-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10013791
关键词：
Abstinence Adaptive Behaviors Affective Aftercare Amphetamines Behavioral Biological Markers Brain Brain region Clinical Cocaine Cognitive Controlled Study Data Development Disease Dopamine Double-Blind Method FDA approved Feasibility Studies Frequencies Functional Magnetic Resonance Imaging Functional disorder Health Homelessness Intervention Left Legal Major Depressive Disorder Measures Methods Morbidity - disease rate Occupational Participant Patient Selection Personal Satisfaction Pharmaceutical Preparations Placebos Prediction of Response to Therapy Prefrontal Cortex Process Property Psychopathology Psychostimulant dependence Randomized Refractory Relapse Research Design Rewards Role Services Signal Transduction Suicide Toxicology Urine Veterans adaptive learning addiction base cost effective design disability drug of abuse functional MRI scan functional status improved magnetic field methamphetamine use neuropsychiatry psychosocial randomized controlled study relapse prediction relating to nervous system repetitive transcranial magnetic stimulation reward processing sham-controlled study social deficits stimulant use stimulant use disorder treatment comparison treatment group

项目摘要

Stimulant use disorder accounts for significant disability and dysfunction among Veterans. We currently do not have effective somatic treatments for this condition. This proposal will conduct a feasibility study to determine our ability to administer and complete a double-blind, sham-controlled randomized study using repetitive transcranial stimulation (rTMS) for treating stimulant use disorder. Half of the participants will be randomly assigned to receive sham treatment and the other half to receive active rTMS to the dorsolateral prefrontal cortex (DLPFC). We will also obtain pilot data supporting the efficacy of rTMS on reducing relapse rates and improving psychosocial functioning. And lastly, we will complete an exploratory aim in which we will obtain pilot data on the ability of fMRI scans to yield biomarkers that will be useful in selecting which Veterans would most benefit from intensive interventions such as rTMS

兴奋剂使用障碍是退伍军人严重残疾和功能障碍的原因。我们目前还没有针对这种情况的有效躯体治疗方法。该提案将进行可行性研究，以确定我们管理和完成双盲、假对照的能力使用重复经颅刺激 (rTMS) 治疗兴奋剂使用的随机研究紊乱。一半的参与者将被随机分配接受假治疗，另一半将被随机分配接受假治疗一半接受背外侧前额皮质（DLPFC）的主动 rTMS。我们还将获得试点数据支持 rTMS 在降低复发率和改善心理社会方面的功效发挥作用。最后，我们将完成一个探索性目标，其中我们将获得有关功能磁共振成像扫描能够产生生物标志物，这些生物标志物将有助于选择哪些退伍军人最愿意从强化干预措施（如 rTMS）中获益