Mechanisms of Inhaled B(a)P-Induced Neurotoxicity

吸入苯并芘引起的神经毒性机制

• 批准号: 8136411
• 负责人: Darryl Brice Hood
• 金额: $ 28.47万
• 依托单位: MEHARRY MEDICAL COLLEGE
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-18 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8136411
• 关键词: Aerosols; Affect; Agonist; Animals; Aromatic Polycyclic Hydrocarbons; Behavior; Behavioral; Binding; Binding Sites; Birth; Boxing; Brain; Breathing; Carbon Black; Cells; Cerebral cortex; Child; Cytochrome P450; Data; Defect; Development; Disease; Elderly; Embryonic Development; Environment; Environmental Pollution; Exhibits; Exposure to; Fetus; Fluorescence; Gene Expression; Gene Targeting; Generations; Genes; Genotype; Glutamate Receptor; Glutamates; Goals; High Pressure Liquid Chromatography; Hippocampus (Brain); Homeostasis; Knockout Mice; Learning; Left; Link; Literature; Liver; Measures; Mediating; Memory; Methods; Mixed Function Oxygenases; Modeling; Molecular; Mus; N-Methyl-D-Aspartate Receptors; N-Methylaspartate; NADP; NADPH-Ferrihemoprotein Reductase; NR2A NMDA receptor; Neurons; Neurophysiology - biologic function; Neurotoxins; Outcome; Oxidoreductase; Parents; Pattern; Perinatal Exposure; Phenotype; Physiological; Predisposition; Preparation; Production; Proteins; Publishing; Rattus; Reading; Regulation; Reporter; Slice; Sp4 transcription factor; Space Perception; Structure; Synapses; Synaptic Potentials; Synaptic plasticity; Testing; Time; Tissues; Translating; Up-Regulation; Western Blotting; Work; attenuation; behavior test; critical developmental period; critical period; frontal lobe; in utero; in vivo; lead exposure; methylmercury exposure; mouse model; neurotoxicity; nonhuman primate; novel; offspring; patch clamp; postnatal; pregnant; premature; prenatal; promoter; protein expression; public health relevance; receptor; reconstitution; relating to nervous system; research study; voltage; young adult