Mechanisms of Polycyclic Aromatic Hydrocarbon Toxicity

多环芳烃毒性机制

• 批准号: 7475137
• 负责人: Darryl Brice Hood
• 金额: $ 73.23万
• 依托单位: MEHARRY MEDICAL COLLEGE
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-18 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7475137
• 关键词: Mechanisms; Polycyclic; Aromatic; Hydrocarbon; Toxicity

DESCRIPTION (provided by applicant): This revised ARCH application proposes a project between Meharry Medical College, a historical black college/university (HBCU/MSI), and Vanderbilt University School of Medicine, a research intensive institution (RIU) that focuses on enhancing collaborations between investigators at these institutions in the general area of toxicology. The goal of this proposal is pursue hypothesis-driven research project grant programs in "Molecular Mechanisms of Polycyclic Aromatic Hydrocarbon Toxicity" at MMC in close collaboration with faculty at Vanderbilt University School of Medicine. This arrangement is designed to allow the accomplishment of the following Specific Aims. Specific Aim 1 is to develop the research programs of ARCH faculty as measured by joint, impact publications between MMC-VU research teams by the midpoint of the second year of this initiative. Specific Aim 2 is to develop the research programs of ARCH faculty in a way that fosters the launching of the independent careers of these investigators, as measured by successful acquisition of peer-reviewed funding. The strengths and resources of both institutions have been merged so as to create a joint project that is expected to increase the success rate of research project grant applications by Meharry faculty members to the National Institutes of Environmental Health Sciences (NIEHS). This revised application comprises three main components: 1) the Administrative and Planning Core will be responsible for managing and monitoring the entire project. The administrative core will receive guidance from internal and external advisory committees. 2) The research program development core will consist of three pilot projects and one research project conducted by MMC investigators. The pilot and research projects establish close collaborations between investigators from MMC and Vanderbilt University School of Medicine. 3) A well-integrated facility core is requested to support the ARCH investigators. Over the tenure of the proposed project, these three components will develop into a cohesive program of environmental health science research. The research described in this revised application uses exposure to "B[a]P" as a model to understand the etiology of neurological dysfunction and cancer. REVIEW OF ADMINISTRATIVE PLANNING CORE DESCRIPTION (provided by applicant) The Administrative and Planning core will manage and monitor the progress of this program. Specific objectives for this core will be to provide leadership that will assure the scientific growth and professional development of the MMC investigators; to ensure effective collaboration between MMC scientists and VUMC scientists; to foster an enhanced MMC/VUMC partnership in toxicological training and research by organizing team meetings, seminar series, and relevant workshops, and an annual toxicology symposium; to provide effective management of the ARCH program administratively and fiscally. This core will be directed by Drs Hood, the principal investigator from MMC, and Aschner from VUMC. Both the Internal and External Advisory Committees will offer guidance to the directors of this core. The administrative mechanism that supports this scientific collaboration is straightforward in that the principal investigator is responsible for overall direction of the project while the project leader at the RIU is charged in managing the projects conducted at VUMC. Leadership responsibilities will be shared by the principal investigator at MCC and the RIU leader at VUMC. Operations at the two Institutions will be integrated as a result of the advisory committees, seminars, and other interactive mechanisms.

描述（由申请人提供）： 修订后的 ARCH 申请提出了梅哈里医学院（一所历史悠久的黑人学院/大学 (HBCU/MSI)）和范德比尔特大学医学院（一所研究密集型机构 (RIU)）之间的一个项目，重点是加强这些机构的研究人员之间的合作毒理学的一般领域。该提案的目标是与范德比尔特大学医学院的教师密切合作，在 MMC 的“多环芳烃毒性的分子机制”中推行假设驱动的研究项目资助计划。这种安排旨在实现以下具体目标。具体目标 1 是在该计划的第二年中期，通过 MMC-VU 研究团队之间的联合影响力出版物来衡量 ARCH 教师的研究项目。具体目标 2 是开发 ARCH 教师的研究项目，以促进这些研究人员开展独立职业生涯，以成功获得同行评审资金来衡量。两个机构的优势和资源已合并，以创建一个联合项目，预计将提高梅哈里教员向美国国立环境健康科学研究所 (NIEHS) 申请研究项目资助的成功率。此修订后的应用程序包含三个主要组成部分：1) 行政和规划核心将负责管理和监控整个项目。行政核心将接受内部和外部咨询委员会的指导。 2) 研究计划开发核心将包括由MMC研究人员进行的三个试点项目和一个研究项目。试点和研究项目在 MMC 和范德比尔特大学医学院的研究人员之间建立了密切的合作。 3) 需要一个集成良好的设施核心来支持 ARCH 调查人员。在拟议项目的任期内，这三个组成部分将发展成为一个有凝聚力的环境健康科学研究计划。这份修订后的申请中描述的研究使用“B[a]P”暴露作为模型来了解神经功能障碍和癌症的病因。 行政规划核心审查 描述（由申请人提供） 行政和规划核心将管理和监控该计划的进展。 该核心的具体目标是提供领导力，确保 MMC 研究人员的科学成长和专业发展； 确保 MMC 科学家和 VUMC 科学家之间的有效合作；通过组织团队会议、研讨会系列和相关讲习班以及年度毒理学研讨会，加强 MMC/VUMC 在毒理学培训和研究方面的伙伴关系；在行政和财政上对 ARCH 计划进行有效的管理。该核心将由 MMC 的首席研究员 Hood 博士和 VUMC 的 Aschner 领导。 内部和外部咨询委员会都将为该核心的董事提供指导。支持这种科学合作的管理机制很简单，主要研究者负责项目的总体方向，而 RIU 的项目负责人则负责管理 VUMC 进行的项目。领导职责将由 MCC 的首席研究员和 VUMC 的 RIU 领导共同承担。 两个机构的业务将通过咨询委员会、研讨会和其他互动机制进行整合。