Elucidating the Role of Phospholipase in the Epidemic Typhus Rickettsia

阐明磷脂酶在流行性斑疹伤寒立克次体中的作用

• 批准号: 8145106
• 负责人: JONATHON PETER AUDIA
• 金额: $ 33.4万
• 依托单位: UNIVERSITY OF SOUTH ALABAMA
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-21 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8145106
• 关键词: Antibodies; Attenuated Vaccines; B-Lymphocytes; Back; Bioterrorism; Blocking Antibodies; Caspase-1; Categories; Cell Culture Techniques; Cell Nucleus; Cell surface; Cells; Chloramphenicol; Consensus; Culture Media; Cuprozinc Superoxide Dismutase; Cytolysis; Cytosol; Data; Databases; Development; Diagnostic; Disease; Dominant-Negative Mutation; Doxycycline; Drug resistance; Endothelial Cells; Enzymes; Epidemic; Escherichia coli; Failure; Future; Genetic Engineering; Genome; Goals; Homologous Gene; Human; Hydrolase; Immunofluorescence Microscopy; In Vitro; Infection; Inflammatory Response; Interleukin-1; Intervention; Legionella pneumophila; Lice; Literature; Mediating; Membrane; Modeling; Open Reading Frames; Parasites; Pathogenesis; Phagosomes; Phenotype; Phospholipase; Phospholipase A2; Phospholipases A; Play; Population; Proteins; Reporter; Rickettsia; Rickettsia Infections; Rickettsia prowazekii; Role; Screening procedure; Signal Transduction; Signal Transduction Pathway; Small Interfering RNA; Surface; System; Testing; Tetracyclines; Therapeutic; Therapeutic Intervention; Typhus; Vaccines; Virulence; Virulent; Work; antibody inhibitor; antimicrobial; base; combat; genome sequencing; inhibitor/antagonist; knock-down; macrophage; meetings; member; mutant; novel; pathogen; phospholipase A2 inhibitor; procaspase-1; public health relevance; response; small molecule; success