Multi Source E-Beam kV X-Ray Tube for Image-Guided Radiotheraphy

用于图像引导放射治疗的多源电子束 kV X 射线管

• 批准号: 9266745
• 负责人: DOUGLAS P BOYD
• 金额: $ 52.69万
• 依托单位: TELESECURITY SCIENCES, INC.
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-04-01 至 2018-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9266745
• 关键词: Abdomen; Breathing; Characteristics; Chest; Clinical; Collimator; Colon Carcinoma; Dose; Electron Beam; Eligibility Determination; Ensure; Evaluation; Exposure to; Eye; Funding; Future; Geometry; Health; Image; Industry; Letters; Linear Accelerator Radiotherapy Systems; Lung Neoplasms; Malignant - descriptor; Malignant neoplasm of lung; Malignant neoplasm of prostate; Motion; Normal tissue morphology; Oncologist; Operative Surgical Procedures; Patients; Performance; Periodicity; Phase; Physiologic pulse; Plant Leaves; Positioning Attribute; Power Sources; Price; Production; Radiation; Radiation exposure; Radiation therapy; Rectal Cancer; Reporting; Research; Resolution; Roentgen Rays; Safety; Scanning; Science; Scientist; Series; Side; Source; Spottings; Structure; Surface; System; Testing; Time; Toxic effect; Tube; Tungsten; Update; Vendor; Work; authority; cancer imaging; clinical practice; cone-beam computed tomography; contrast imaging; design; digital; image guided; image guided radiation therapy; imaging system; improved; lung imaging; malignant breast neoplasm; new technology; novel; prototype; public health relevance; temporal measurement; tomosynthesis; treatment planning; tumor; voltage

 DESCRIPTION (provided by applicant): This project will develop a commercial product that will enable for the first time realtime tumor tracking during radiotherapy at an attractive price point and with minimal interference with standard clinical practice. The key novel technology is an optimized multi-source X-ray tube with 19 focal spots that is placed below the multi-leaf collimator (MLC) of a radiotherapy system as shown below. By steering a focused electron beam (e-beam) on a series of 19 cooled tungsten targets in sequence, this system will provide a set of projection images that can be reconstructed into a 20 cm × 20 cm × 20 cm digital tomosynthesis (DTS) volume image that surrounds the radiation target. The projection X-rays are captured by a universal kV-MV imager that can record portal MV images interlaced with the sequence of tomographic kV images. Since the sources are positioned around the perimeter of the MLC, the resulting tomographic cross section images are aligned perpendicular to the axis of the therapy beam. This geometry is referred to as "Beam's Eye View" imaging. The DTS images will be used to provide precise reference coordinates of a tumor surface for programming of the MLC, in near real-time. The preliminary specifications for the system indicate that a repetition rate of 2-3 volume images per second with near 1 mm spatial resolution will be possible. The multi-source e-beam X-ray tube will be developed by substantially the same premier team who developed the original Imatron EBCT scanners and the more recent e-beam luggage scanner. The e-beam team consisting of TeleSecurity Sciences, Inc. scientists, consultants, and vendors has partnered with the premier cone beam CT team at UC Davis along with a key Varian consultant, who are authorities on flat panel X-ray imagers, and in particular the Side-view of the TumoTrakTM in a Truebeam gantry kV-MV imager that will be used in this project to provide simultaneous MV portal imaging with interlaced kV DTS imaging of the tumor position. Phase 1 of the project extended the preliminary work to more precisely define the final design specifications for a future commercial system that will be appropriate for the entire radiotherapy industry. Phase 2 funding will develop a suitable prototype of the multi-source eBeam X-ray tube which will demonstrate the feasibility and performance of the commercial system. The majority of radiotherapy vendors have provided guidance and letters of support for this project. The commercial implementation of the proposed system in future radiotherapy systems will permit treatment plans that will have far improved localization of radiation exposure within reduced margins beyond the apparent boundaries of a malignant mass with a corresponding reduction in exposure to surrounding normal structures. This will be especially important in treating tumors of the chest and upper abdomen during free breathing where periodic motion in the range of 2 cm to 5 cm is often encountered.

 描述（由申请人提供）：该项目将开发一种商业产品，该产品将首次以具有吸引力的价格点实现放射治疗期间的实时肿瘤跟踪，并且对标准临床实践的干扰最小。关键的新技术是优化的多源技术。具有 19 个焦点的 X 射线管，放置在放射治疗系统的多叶准直器 (MLC) 下方，如下图所示，通过在一系列 19 个冷却钨上引导聚焦电子束（电子束）。该系统将提供一组投影图像，这些图像可以重建为围绕辐射目标的 20 cm × 20 cm × 20 cm 数字断层合成 (DTS) 体积图像。投影 X 射线由通用设备捕获。 kV-MV 成像仪可以记录与断层 kV 图像序列交错的射野 MV 图像，由于源位于 MLC 的周边，因此生成的断层断面图像垂直对齐。该几何形状被称为“光束眼视图”成像，将用于为 MLC 的初步编程提供精确的参考坐标。该系统的规格表明，每秒 2-3 个体积图像的重复率和接近 1 毫米的空间分辨率将是可能的。多源电子束 X 射线管将由开发该系统的主要团队开发。原装 Imatron EBCT 扫描仪由 TeleSecurity Sciences, Inc. 的科学家、顾问和供应商组成的电子束团队与加州大学戴维斯分校的顶尖锥形束 CT 团队以及一位重要的瓦里安顾问（他们都是权威人士）合作。平板 X 射线成像仪，特别是 Truebeam 龙门 kV-MV 成像仪中 TumoTrakTM 的侧视图，该成像仪将用于本项目，通过隔行 kV DTS 提供同步 MV 射野成像该项目的第一阶段扩展了初步工作，以更精确地定义未来整个商业系统的最终设计规范，该系统将适用于放射治疗行业，第二阶段的资金将开发一个合适的多用途原型。源电子束 X 射线管将证明商业系统的可行性和性能。大多数放射治疗供应商已为该项目提供了指导和支持信，拟议系统在未来放射治疗系统中的商业实施将允许制定治疗计划。将在减少的范围内大大改善辐射暴露的定位边缘超出恶性肿块的明显边界，相应减少对周围正常结构的暴露，这对于自由呼吸期间的胸部和上腹部肿瘤尤为重要，其中周期性运动范围为 2 厘米至 5 厘米。经常遇到。