Exposure Science, Characterization, and Generation

曝光科学、表征和生成

• 批准号: 8075054
• 负责人: Timothy V Larson
• 金额: $ 24.09万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8075054
• 关键词: Aerosols; Air Pollutants; Animals; Clinical Research; Core Facility; Diesel Exhaust; Epidemiologic Studies; Epidemiology; Evaluation; Gases; Generations; Human; Inhalation Exposure; Laboratories; Modification; Resources; Science; Source; Toxic effect; Toxicology; Universities; Washington; biological systems; exhaust; exposed human population; particle; planetary Atmosphere; receptor; research study; response

The overall objective of the Controlled Exposure Facility core is to provide capabilities for the study of human and animal toxicological responses to inhalation exposures of combustion-generated particles and gases. This core will primarily provide technical support, facilities, management and coordination of controlled exposure experiments for the toxicology and human clinical studies, and will also provide technical advice to the epidemiology project on characterization of atmospheric aerosols, exposure assessment of airborne particles and gases, and source/receptor relationships of ambient air pollutants. . The combustion exhaust exposures in support of the toxicology and human clinical studies will take place in a recently built and wellcharacterized exposure facility in the Northlake Laboratory of the University of Washington. This exposure generation and characterization activity will be achieved via the following specific aims: 1) Generate relevant combustion exhaust exposure atmospheres; 2: Characterize particles and gases generated during each exposure; 3) Modify exposure atmospheres to enhance understanding of the toxicity of diesel exhaust. These modifications will provide experimental conditions that permit experimental evaluation of toxicity to biological systems.

受控暴露设施核心的总体目标是为人类研究提供能力 以及动物对吸入燃烧产生的颗粒和气体的毒理学反应。 该核心将主要提供技术支持、设施、管理和受控协调 毒理学和人体临床研究的暴露实验，还将提供技术建议 关于大气气溶胶特征、空气传播暴露评估的流行病学项目 颗粒和气体，以及环境空气污染物的源/受体关系。 。燃烧废气 支持毒理学和人体临床研究的暴露将在最近建造的、经过充分表征的实验室中进行 华盛顿大学北湖实验室的曝光设施。此次曝光 生成和表征活动将通过以下具体目标来实现： 1) 生成相关的 燃烧废气暴露大气； 2：表征每个过程中产生的颗粒和气体 接触; 3) 修改暴露气氛以增强对柴油机尾气毒性的了解。 这些修改将提供实验条件，允许对毒性进行实验评估 生物系统。