Epidemiology of Helicobacter Pylori Transmission
幽门螺杆菌传播的流行病学
基本信息
- 批准号:8102528
- 负责人:
- 金额:$ 17.6万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2010
- 资助国家:美国
- 起止时间:2010-07-12 至 2012-06-30
- 项目状态:已结题
- 来源:
- 关键词:AddressAffectAftercareAnimal ModelAntigensAreaBiopsyCaliforniaChinaChronicCirrhosisColombiaCommunity SurveysComplement Factor HComplexCountyDeveloped CountriesDeveloping CountriesDevelopmentDiagnosticDiarrheaDiseaseDisease OutcomeDown-RegulationEconomic DevelopmentEndoscopyEpidemiologyEquilibriumEsophageal AdenocarcinomaExtinction (Psychology)FamilyFecesFundingGastric AdenocarcinomaGastric lymphomaGastroenteritisGastroesophageal reflux diseaseHelicobacterHelicobacter InfectionsHelicobacter pyloriHelminthsHepatitis VirusesHouseholdHumanImmigrantImmune responseImmune systemImmunityImmunoglobulinsImmunologic EpidemiologyImmunologicsIncidenceIndividualInfectionInfectious AgentInflammationInterferon Type IIIntestinesIron deficiency anemiaJointsLightMalignant neoplasm of liverMethodologyMycobacterium tuberculosisOrganismOutcomePathogenesisPatientsPatternPeptic UlcerPeripheral Blood Mononuclear CellPersonsPhasePlayPopulationPrevalenceProductionPurpuraPylorusResearchResearch PersonnelRiskRisk FactorsSamplingSignal TransductionStimulusStomachTuberculosisVaccinesbody systemcell mediated immune responsecytokinehuman diseaselatent infectionmalignant stomach neoplasmmicrobialpathogenprogramsprotective effectresponsetransmission processtreatment effectvaccine development
项目摘要
Economic development has been accompanied by dramatic changes in the prevalence of some chronic infections.
H. pylori, for example, is nearing extinction in industrialized countries. In developing countries, however, chronic
infections remain common and act on the host simultaneously, resulting in competing signals to the immune system. In
our prior submission, we identified protective effects of H. pylori on gastroenteritis incidence. This finding exemplifies
the complex interactions that can occur among infectious agents in a single host to affect disease outcome. The
objective of our current proposal is to better characterize how infections interact within humans. Specifically, we wish
to see how host response to gastric infection with H. pylori varies in the setting of strong chronic inducers of Thl
response (M. tuberculosis) or Th2 response (intestinal helminths). Specific aims are 1) to characterize the joint
distribution of the three target pathogens in a defined population; 2) to characterize gastric and systemic immunologic
profiles of mixed infections, and 3) to assess changes in these immunologic profiles after treatment of infection. In the
setting of mixed infection, we speculate helminths cause down-regulation of cell-mediated immune responses to H.
pylori whereas latent Mycobacterium tuberculosis (LTBI) upregulates the response. We further hypothesize that
eradication of either helminths or LTBI reverses these effects. To be conducted in recent immigrants in Santa Clara
county, the proposed research will have three parts. In Part 1, community surveys will be carried out and the
distributions of infection in 1750 subjects will be evaluated. In Part 2, a subset of 200 subjects from phase one will
undergo more extensive immunologic profiling to evaluate the effects of individualand co-infection on systemic
cytokine arid immunoglobulin levels. In Part three, subjects who participated in Part II will undergo treatment of either
helminths, latent tuberculosis infection or no treatment and changes in systemic immunologic outcomes will be
assessed; in a subset of 75, immune responses to H. pylori in the stomach will also be assessed with endoscopy and
biopsy.
How humans respond to the spectrum of chronic infections that they harbor is a question of critical importance to
vaccine development and to our understanding of the variability in manifestations of human disease. In addition to
shedding light on why outcomes of H. pylori differ from person-to-person and from population-to-population, we hope
this study will also expand the toolkit of immunoepidemiology for further studies in human populations.
经济发展伴随着某些慢性感染的发生率的巨大变化。
例如,幽门螺杆菌在工业化国家即将灭绝。然而,在发展中国家中
感染仍然很普遍,并同时对宿主作用,从而导致免疫系统的竞争信号。在
我们先前提交的是,我们确定了幽门螺杆菌对胃肠炎发病率的保护作用。这一发现例证了
单个宿主中传染剂之间可能发生的复杂相互作用,以影响疾病结果。这
我们目前的建议的目的是更好地表征感染如何在人类内部相互作用。具体来说,我们希望
查看宿主对幽门螺杆菌对胃感染的反应如何在THL强慢性诱导剂的情况下各不相同
反应(结核下)或Th2反应(肠舵)。具体目的是1)表征关节
在定义的人群中分布三个目标病原体; 2)表征胃和全身免疫学
混合感染的特征和3)评估感染治疗后这些免疫学特征的变化。在
混合感染的设置,我们推测蠕虫会导致细胞介导的对H的免疫反应下调。
幽门螺杆菌,而潜在的分枝杆菌结核病(LTBI)上调了反应。我们进一步假设
根除蠕虫或LTBI会逆转这些影响。将在最近在圣克拉拉的移民中进行
县,拟议的研究将有三个部分。在第1部分中,将进行社区调查,并
将评估1750名受试者的感染分布。在第2部分中,第一阶段的200名受试者的子集将
进行更广泛的免疫学分析,以评估单个和共同感染的影响
细胞因子干旱免疫球蛋白水平。在第三部分中,参与第二部分的受试者将接受任何两者的治疗
蠕虫,潜在的结核病感染或没有治疗,全身免疫结局的变化将是
评估;在75的子集中,对胃中幽门螺杆菌的免疫反应也将通过内窥镜检查和
活检。
人类如何应对慢性感染的范围,这是一个至关重要的问题
疫苗的发展以及我们对人类疾病表现变异性的理解。此外
阐明了为什么幽门螺杆菌的结果与人与人之间以及人口之间的结果不同,我们希望
这项研究还将扩大免疫ePidemiology的工具包,以在人群中进行进一步研究。
项目成果
期刊论文数量(16)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Household transmission of gastroenteritis.
- DOI:10.3201/eid1107.040889
- 发表时间:2005-07
- 期刊:
- 影响因子:11.8
- 作者:Perry S;de la Luz Sanchez M;Hurst PK;Parsonnet J
- 通讯作者:Parsonnet J
Helicobacter pylori and risk of gastroenteritis.
幽门螺杆菌和胃肠炎的风险。
- DOI:10.1086/421705
- 发表时间:2004
- 期刊:
- 影响因子:0
- 作者:Perry,Sharon;Sanchez,Luz;Yang,Shufang;Haggerty,ThomasD;Hurst,Philip;Parsonnet,Julie
- 通讯作者:Parsonnet,Julie
Gastroenteritis and transmission of Helicobacter pylori infection in households.
- DOI:10.3201/eid1211.060086
- 发表时间:2006-11
- 期刊:
- 影响因子:11.8
- 作者:Perry S;de la Luz Sanchez M;Yang S;Haggerty TD;Hurst P;Perez-Perez G;Parsonnet J
- 通讯作者:Parsonnet J
The immune response to tuberculosis infection in the setting of Helicobacter pylori and helminth infections.
- DOI:10.1017/s0950268812001823
- 发表时间:2013-06
- 期刊:
- 影响因子:4.2
- 作者:Perry, S.;Chang, A. H.;Sanchez, L.;Yang, S.;Haggerty, T. D.;Parsonnet, J.
- 通讯作者:Parsonnet, J.
Helicobacter pylori infection in different generations of Hispanics in the San Francisco Bay Area.
旧金山湾区不同代西班牙裔的幽门螺杆菌感染情况。
- DOI:10.1093/aje/kwi207
- 发表时间:2005
- 期刊:
- 影响因子:0
- 作者:Tsai,ChiaojungJ;Perry,Sharon;Sanchez,Luz;Parsonnet,Julie
- 通讯作者:Parsonnet,Julie
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Julie Parsonnet其他文献
Julie Parsonnet的其他文献
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家庭三氯生和三氯卡班的使用与婴儿微生物群的发育
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