Kinematic Modeling of Asymmetric Vocal Fold Vibration

非对称声带振动的运动学建模

基本信息

批准号：
8123324
负责人：
Robin Amy Samlan
金额：
$ 4.07万
依托单位：
UNIVERSITY OF ARIZONA
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-08-02 至 2012-08-01
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8123324
关键词：
Acoustics Address Affect Airway Resistance Area Behavioral Characteristics Clergy Clinical Clinical assessments Collection Coupled Databases Dysphonia Educational process of instructing Evaluation Frequencies Goals Human Image Impairment Individual Larynx Law Enforcement Lead Left Measurement Measures Medial Medicine Military Personnel Modeling Modification Motion Movement Nodal Operative Surgical Procedures Output Patients Pattern Perception Phase Production Public Health Reporting Research Secondary to Severities Shapes Signal Transduction Simulate Source Specific qualifier value Speech Structure Surface System Testing Trachea Variant Voice Voice Disorders Voice Quality Withdrawal Work base constriction design human subject in vivo indexing kinematics pressure public health relevance research study simulation social vibration vocal cord

项目摘要

DESCRIPTION (provided by applicant): The goal of this project is to develop a clearer understanding of how structural and vibratory asymmetry of the vocal folds affects both clinical measures of vocal function and severity ratings of dysphonia. Such asymmetries are key features underlying many voice disorders, including unilateral vocal fold motion impairment (VFMI), and likely contribute to the perception of breathy voice quality. Clinical voice evaluation and management are based in understanding how vocal fold vibration patterns are related to vocal function measures and perception. Determining how specific asymmetries contribute to the vocal output, however, is limited in human subjects by difficulty imaging the three-dimensional movement characteristics of vocal fold vibration, inability to systematically vary individual components of vibration, and challenges of separating the glottal source (i.e., vocal fold vibration) from filter (i.e., vocal tract) characteristics of aerodynamic and acoustic signals. Delineating these causal relationships can immediately impact the clinical use and interpretation of vocal function measures and treatment decisions for patients with breathy voice secondary to VFMI. The approach for this research is to use a kinematic model of vocal fold vibration that will allow for differential left/right control of vocal fold adduction, medial surface bulging, vibratory nodal point, phase, and fundamental frequency. The vocal fold model will be coupled to a comprehensive model of speech production, with which glottal area, vocal fold contact area, glottal airflow and output pressure can be simulated as if they were produced by a human talker. The inclusion of a trachea and vocal tract in the system allows for additional testing of the effect of airspace on the resulting output signals. For this project, the vocal fold structure and vibratory parameters selected for systematic modification will be consistent with changes reported in VFMI, and vocal fold and vocal tract changes occurring with surgical and behavioral management will be tested. The research will be guided by three hypotheses: 1) the effects of structural and vibratory asymmetry of the vocal folds can be characterized with a set of clinically-feasible acoustic and aerodynamic measures of vocal function, 2) the degree of structural and vibratory asymmetry will be directly related to severity ratings of dysphonia, and 3) constriction of the epilaryngeal section of the supraglottal vocal tract will decrease the degree of dysphonia registered both by vocal function measures and perceptually-based severity ratings. Three specific aims are designed to address these hypotheses: 1) To generate a database of simulated signals based on 47 combinations of asymmetric settings for vocal fold adduction, medial surface bulging, vibratory nodal point, phase, and fundamental frequency. The simulations will be repeated for the vowels /a/, /i/, /u/, and /ae/ and for a constricted epilarynx. 2) To measure, from each collection of signals generated in Aim 1, a battery of clinically-feasible kinematic, aerodynamic, and acoustic measures. 3) To conduct perceptual experiments that assess the severity of the dysphonia represented by the signals generated in Aim 1. PUBLIC HEALTH RELEVANCE: Vocal fold motion impairment with asymmetric vocal fold vibration leads to a breathy, weak voice, which is undesirable for people in many professions such as teaching, law enforcement, clergy, medicine, or the military. Breathy voice caused by asymmetric vocal fold vibration becomes a public health concern when it interferes with an individual's ability to communicate at work and leads to withdrawal from social situations. Better understanding of the how specific asymmetries contribute to voice quality will lead to more efficient evaluation and treatment.

描述（由申请人提供）：该项目的目的是更清楚地了解声带的结构和振动不对称性如何影响声音功能的临床措施和吞咽困难的严重程度等级。这样的不对称是许多语音障碍的关键特征，包括单方面的声带运动障碍（VFMI），并且可能有助于感知呼吸的语音质量。临床语音评估和管理基于了解声带振动模式与声带函数指标和感知如何相关。然而，通过难以成像，声音折叠振动的三维运动特征，无法系统地改变单个振动的组成部分，以及将光门来源（即声音折叠振动）与滤波器（即，在滤波器上的特征）分离出（即声音振动）的挑战，从而有助于（即，在人类主题中），从过滤器（即声音振动）分开（即，声音）特征，在人类受试者中，确定特定的不对称性如何对声音输出的贡献是有限的。描述这些因果关系可以立即影响继发于VFMI的呼吸声音患者的声乐功能度量和治疗决策的临床使用和解释。这项研究的方法是使用声带振动的运动学模型，该模型将允许左/右控制声带内收，内侧表面膨胀，振动节点点，相位和基本频率。声带模型将耦合到综合语音生产模型，该模型与该模型相结合，与人类说话者产生一样，可以模拟它们，声带接触区域，震颤气流和输出压力可以模拟。在系统中包含气管和声带，可以进行其他测试空域对产生的输出信号的影响。对于此项目，选择用于系统修改的声带结构和振动参数将与VFMI报告的变化一致，并且将测试声带折叠和声带变化，并将测试手术和行为管理。这项研究将由三个假设进行指导：1）嗓音褶皱的结构和振动不对称的影响可以通过一组临床上可行的声学和空气功能的衡量标准来表征，2）结构和振动不对称的程度与epyphonia和3）的decyphore sumptrag the Epyphonia和3）直接相关。道会降低通过人声功能度量和基于感知的严重程度等级注册的吞咽困难程度。设计三个特定的目标旨在解决这些假设：1）基于47种不对称设置的模拟信号数据库，用于声带内收，内侧表面膨胀，振动淋巴结点，相位和基本频率。元音 /a /， /i /， /u /和 /ae /的仿真将重复进行，并为收缩的epilarynx重复。 2）从AIM 1中产生的每个信号集合中测量一组临床上可行的运动学，空气动力学和声学测量。 3）进行感知实验，以评估AIM 1中产生的信号表示吞咽困难的严重程度。公共卫生相关性：声带运动障碍带有不对称的人声折叠振动会导致呼吸，声音疲软，这对于许多专业的人（例如教学，执法，神职人员，医学或军事力量）是不希望的。当它干扰个人在工作中交流并导致退出社交情况时，由不对称的声带振动引起的呼吸声成为公共卫生的关注。更好地了解特定的不对称性如何促进语音质量将导致更有效的评估和治疗。