ARIC - JHU FIELD CENTER - DIVERSITY SUPPLEMENT

ARIC - JHU 野外中心 - 多样性补充

• 批准号: 10054600
• 负责人: JOSEF CORESH
• 金额: $ 23.38万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-16 至 2020-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10054600
• 关键词: ARIC; JHU; FIELD; CENTER; DIVERSITY

The Atherosclerosis Risk in Communities (ARIC) Study was initiated in 1985 with two components: community-based surveillance and a prospective cohort study. The community surveillance aimed to monitor trends in hospitalized myocardial infarction (MI), fatal coronary heart disease (CHD) in four U.S. communities: Forsyth County, NC; Jackson, MS; suburbs of Minneapolis, MN; and Washington County, MD. Surveillance for hospitalized heart failure (HF) events was added in 2005. The communities were selected to provide data across four (4) geographic locations with a range of mortality rates, in urban, suburban, and rural settings. The cohort study aimed to investigate the risk factors for and natural history of atherosclerosis and development of clinical atherosclerosis in middle-aged white or African American adults from the same communities. The study recruited in 15,792 white or African American participants initially aged 45-64 years and selected participants received triennial clinical exams over the first ten years of the study (1987-1989, 1990-1992, 1993-1995, and 1996-1998), with a fifth clinical exam in 2011-2013, providing a rich set of data on physical, behavioral, genetic, and psychosocial factors. Since 1988, the cohort has been contacted annually and in 2011 semiannual follow-up was initiated. Findings have been presented in over 1,400 publications as of 2014. Participants were examined for evidence of subclinical atherosclerosis using B-mode ultrasound in carotid and popliteal arteries, ankle-brachial index measurement, and retinal photography and, in subsets, abdominal aortic CT, and hemostatic factors; established and putative laboratory risk markers; socioeconomic, psychological, behavioral, and environmental characteristics; and genetic factors. Examinations included a variety of components, with a grant-funded detailed cognitive function testing component added in the most recent exam during 2011-2013. Blood samples have been assayed for putative biochemical risk factors and stored for case-control studies. DNA has been extracted and lymphocytes cryopreserved (for possible immortalization) for study of candidate genes, genome-wide scanning, expression, and other –omics investigations. Participation of the surviving cohort was 91, 82, 74, and 65% at each of the respective follow-up examinations. Since baseline, cohort members have also been contacted every 12 months to obtain information on vital status, current residence, major illness or injury, and hospitalizations occurring between contacts to identify clinical Cardiovascular Disease (CVD) events. Cohort contact was 84% at the last completed follow-up ending on December 31, 2013.

社区动脉粥样硬化风险 (ARIC) 研究始于 1985 年，包括两个部分：基于社区的监测和前瞻性队列研究。社区监测旨在监测住院心肌梗塞 (MI) 和致命性冠心病 (CHD) 的趋势。新增了四个美国社区：北卡罗来纳州福赛斯县、密西西比州杰克逊市、明尼苏达州明尼阿波利斯市郊区和马里兰州华盛顿县。 2005 年。选择社区提供四 (4) 个地理位置的城市、郊区和农村地区不同死亡率的数据。该队列研究旨在调查动脉粥样硬化及其发展的风险因素和自然史。该研究招募了 15,792 名年龄在 45 岁至 64 岁之间的白人或非裔美国人参与者，并在前十年内每三年接受一次临床检查。该研究（1987-1989年、1990-1992年、1993-1995年和1996-1998年）进行了第五次临床检查，并于2011-2013年进行了第五次临床检查，提供了自1988年以来有关身体、行为、遗传和心理社会因素的丰富数据。 ，每年都会联系该队列，并于 2011 年启动半年一次的随访调查结果。截至 2014 年，已发表超过 1,400 篇出版物。使用颈动脉和腘动脉 B 型超声、踝肱指数测量和视网膜摄影，以及腹主动脉 CT 和确定的止血因素，对参与者进行了亚临床动脉粥样硬化的证据检查；假定的实验室风险标记；社会经济、心理、行为和环境特征；检查包括各种组成部分，以及资助的详细认知功能。 2011-2013 年最近一次检查中添加了测试成分，已对血液样本进行了假定的生化危险因素分析，并提取了 DNA 以用于病例对照研究，并冷冻保存了淋巴细胞（用于可能的永生化）以用于研究候选基因、基因组。自基线以来，存活队列的参与率分别为 91%、82%、74% 和 65%。每 12 个月就会联系一次队列成员，以获取有关生命状况、当前居住地、重大疾病或受伤以及接触期间发生的住院情况的信息，以识别临床心血管疾病 (CVD) 事件。在上次完成时，队列接触率为 84%。后续行动于 2013 年 12 月 31 日结束。