THE ATHEROSCLEROSIS RISK IN COMMUNITIES (ARIC) STUDY - FIELD CENTER - TASK ORDER 01, TASK AREA A

社区动脉粥样硬化风险 (ARIC) 研究 - 现场中心 - 任务令 01，任务区 A

• 批准号: 10788250
• 负责人: JOSEF CORESH
• 金额: $ 93.59万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-11-15 至 2023-11-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10788250
• 关键词: Adult; African American; Amyloid deposition; Ancillary Study; Area; Atherosclerosis; Atherosclerosis Risk in Communities; Atrial Fibrillation; Biochemical; Biological Assay; Blood Vessels; Blood specimen; Brain; Candidate Disease Gene; Cardiovascular Diseases; Case/Control Studies; Clinical; Cognition; Cohort Studies; Collaborations; Communities; Contracts; Coronary heart disease; County; Cryopreservation; DNA; Data; Data Collection; Dementia; Diabetes Mellitus; EFRAC; Electrocardiogram; Environmental Risk Factor; Event; Fostering; Funding; Genetic; Genome Scan; Geographic Locations; Goals; Grant; Heart failure; Hospitalization; Injury; Investigation; Lymphocyte; Monitor; Myocardial Infarction; Natural History; Participant; Policies; Process; Prospective, cohort study; Publications; Qualifying; Research Personnel; Risk Factors; Subgroup; Technology; United States National Institutes of Health; Ventricular Dysfunction; Vital Status; Washington; aged; arterial stiffness; caucasian American; clinical development; clinical examination; clinical predictors; cohort; coronary artery calcification; data sharing; follow-up; member; middle age; mortality; novel; preservation; recruit; residence; rural setting; suburb; trend

The Atherosclerosis Risk in Communities (ARIC) Study was initiated in 1985 with two components: community-based surveillance and a prospective cohort study. The community surveillance aimed to monitor trends in hospitalized myocardial infarction (MI), fatal coronary heart disease (CHD) in four U.S. communities: Forsyth County, NC; Jackson, MS; suburbs of Minneapolis, MN; and Washington County, MD. Surveillance for hospitalized heart failure (HF) events was added in 2005. The communities were selected to provide data across four (4) geographic locations with a range of mortality rates, in urban, suburban, and rural settings. The cohort study aimed to investigate the risk factors for and natural history of atherosclerosis and development of clinical atherosclerosis in middle-aged white or African American adults from the same communities. The study recruited in 15,792 white or African American participants initially aged 45-64 years and selected participants received triennial clinical exams over the first ten years of the study (1987-1989, 1990-1992, 1993-1995, and 1996-1998). The clinical exam in 2011-13 was conducted on over 6,500 participants 69-89 years with a focus on characterizing heart failure stages in community-dwelling participants and enabling identification of genetic and environmental factors leading to ventricular dysfunction and vascular stiffness. These data provided the basis for several ancillary studies covering a breadth of topics. The clinical exam in 2018-19 on almost 3,600 participants 75 years and older supported exam components from 12 NIH grant-funded ancillary studies on topics including progression of Heart Failure with preserved Ejection Fraction (HFpEF), coronary artery calcification, atrial fibrillation burden detected by novel continuous ECG monitoring technology, diabetes, dementia, brain amyloid deposition, and changes in arterial stiffness and cognition. Participation of the surviving cohort was 91, 82, 74, 65, and 50% at each of the respective follow-up examinations. Blood samples have been assayed for putative biochemical risk factors and stored for case-control studies. DNA has been extracted and lymphocytes cryopreserved (for possible immortalization) for study of candidate genes, genome-wide scanning, expression, and other –omics investigations. Since baseline, cohort members have also been contacted every 12 months (and every 6 months since 2012) to obtain information on vital status, current residence, major illness or injury, and hospitalizations occurring between contacts to identify clinical cardiovascular disease (CVD) events. Cohort contact was 78% at the last completed follow-up period. Findings have been presented in over 2,600 publications as of 2021.

社区动脉粥样硬化风险 (ARIC) 研究始于 1985 年，包括两个部分：基于社区的监测和前瞻性队列研究。社区监测旨在监测住院心肌梗塞 (MI) 和致命性冠心病 (CHD) 的趋势。新增了四个美国社区：北卡罗来纳州福赛斯县、密西西比州杰克逊市、明尼苏达州明尼阿波利斯市郊区和马里兰州华盛顿县。 2005 年。选择社区提供四 (4) 个地理位置的城市、郊区和农村地区不同死亡率的数据。该队列研究旨在调查动脉粥样硬化及其发展的风险因素和自然史。该研究招募了 15,792 名年龄在 45 岁至 64 岁之间的白人或非裔美国人参与者，并在前十年内每三年接受一次临床检查。该研究（1987-1989、1990-1992、1993-1995 和 1996-1998）在 2011-13 年对 6,500 多名 69-89 岁的参与者进行了临床检查，重点是描述社区居住的心力衰竭阶段。参与者并能够识别导致心室功能障碍和血管僵硬度的遗传和环境因素。 2018-19 年对近 3,600 名 75 岁及以上参与者进行的临床检查支持了 12 项 NIH 资助的辅助研究的考试内容，主题包括射血分数保留的心力衰竭 (HFpEF) 的进展。 ）、冠状动脉钙化、新型连续心电图监测技术检测到的心房颤动负荷、糖尿病、痴呆、脑淀粉样蛋白沉积以及动脉变化存活队列的参与率分别为 91%、82%、74%、65% 和 50%。自基线以来，每 12 次就与队列成员联系一次。几个月（自 2012 年以来每 6 个月）获取有关接触者之间生命状况、当前居住地、重大疾病或受伤以及住院情况的信息，以识别临床心血管疾病 (CVD) 事件。在最后一次完成的随访中，队列接触率为 78%。截至 2021 年，研究结果已在 2,600 多种出版物中发表。