PCTC Administrative Coordinating Center

PCTC行政协调中心

基本信息

批准号：
10010429
负责人：
MICHAEL L TERRIN
金额：
$ 118.42万
依托单位：
UNIVERSITY OF MARYLAND BALTIMORE
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-09-20 至 2023-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10010429
关键词：
Advisory Committees Agreement Authorization documentation Award Basic Science Biocompatible Materials Bioinformatics Biological Sciences Budgets Cell Line Cell Therapy Cellular biology Collaborations Committee Members Communication Communities Computer software Consultations Data Documentation Electronic Mail Equipment Evaluation Facebook Funding Goals Heart Diseases Hematological Disease Individual Infrastructure Institution Interdisciplinary Study Interval training Link Lung diseases Methods Modeling Monitor National Heart, Lung, and Blood Institute Nature Parents Participant Pilot Projects Postdoctoral Fellow Preparation Principal Investigator Procedures Progress Reports Protocols documentation Reagent Research Research Personnel Research Proposals Resources Role Running Scientist Secure Source Stem cells System Telephone Time Training Programs Translating Translational Research Twitter U-Series Cooperative Agreements United States Food and Drug Administration Update Work base disease mechanisms study experience food preparation graduate student improved innovation meetings novel therapeutics programs repository research and development response skill acquisition social media symposium training opportunity web page web site

项目摘要

Abstract To meet the need of the NHLBI Progenitor Cell Translational Consortium (PCTC) for 1)administrative infrastructure to organize interactions and facilitate collaborations between PCTC investigators, 2) oversight of programs of programs using set-aside funds to stimulate collaborative research and skills development, 3) timely sharing of PCTC-generated data and reagents among PCTC investigators and with the research community, and 4) for facilitated access to expertise for preparation of U.S. Food and Drug Administration (FDA) IND and IDE applications, we propose a PCTC Coordinating Center in response to RFA-HL-16-022, staffed by individuals who bring years of experience working along similar lines in the NHLBI Progenitor Cell Biology Consortium (PCBC) Administrative Coordinating Center (ACC); they have extensive experience in coordinating centers, organization and conduct of solicitation/review/ and award of proposals for research or skills development, FDA procedures for preparation of IND and IDE applications, collaborative research under cooperative agreements, consortium infrastructure, web site, communications, monitoring and documentation. We will adapt and advance our infrastructure (hardware, software, web sites and links, offices, office equipment and staff) in place for the PCBC ACC to extend to the PCTC resulting in an immediate, running start for the PCTC on day one. We will proceed to expand the functions of the extant infrastructure to additional, innovative use of social media to reach all corners of the PCTC community and out to the broader research community. We will continue the PCBC procedures for Skills Development support as well as support of solicitation/review/and award of pilot and ancillary/collaborative studies of which there have been 31 ancillary/collaborative study awards and 14 pilot study awards resulting from over 200 applications and 26 "jump start (small post-doctoral fellow pilot study)" awards from 78 applications. Our proposal is both highly efficient and innovative because of the expertise and experience of our investigators, the uninterruptable nature of their backup for each other and the uninterruptable nature of the systems we will extend and update from the PCBC to the PCTC. The PCBC ACC was able to accomplish all that it did with less than 3% of the consortium budget spent outside of the research hubs, cores and their projects. The channeling of resources to translational research, basic research necessary to support translational research and skills development that building on the PCBC infrastructure and the additional extension of our infrastructure through social media will be substantial.

抽象的满足 NHLBI 祖细胞转化联盟 (PCTC) 的需要 1) 行政组织互动并促进 PCTC 调查人员之间合作的基础设施，2) 监督使用预留资金来刺激合作研究和技能开发的方案的方案，3) 在 PCTC 研究人员之间以及研究中及时共享 PCTC 生成的数据和试剂社区，以及 4) 方便获得专业知识，为美国食品和药物管理局的准备做好准备 (FDA) IND 和 IDE 申请，我们建议设立 PCTC 协调中心以响应 RFA-HL-16-022，其员工均拥有多年在 NHLBI 祖细胞领域从事类似工作的经验生物联盟（PCBC）行政协调中心（ACC）；他们拥有丰富的经验协调中心、组织和进行研究或提案的征集/审查/授予技能开发、FDA IND 和 IDE 申请准备程序、合作研究合作协议、联合体基础设施、网站、通信、监测和文件。我们将调整和推进我们的基础设施（硬件、软件、网站和链接、办公室、办公室设备和人员）到位，以便 PCBC ACC 扩展到 PCTC，从而立即开始运行第一天的 PCTC。我们将继续将现有基础设施的功能扩展到更多、创新地使用社交媒体来覆盖 PCTC 社区的各个角落并进行更广泛的研究社区。我们将继续采用 PCBC 程序来支持技能发展以及支持征集/审查/授予试点和辅助/合作研究，其中已有 31 项辅助/合作研究奖和 14 个试点研究奖来自 200 多个申请和 26 “快速启动（小型博士后试点研究）”奖项来自 78 份申请。由于我们的专业知识和经验，我们的建议既高效又创新调查员、他们相互支持的不间断性质以及我们将从 PCBC 扩展到 PCTC 的系统进行扩展和更新。 PCBC ACC 能够完成所有任务它只用了不到 3% 的财团预算花在研究中心、核心及其之外项目。将资源引导至转化研究、支持必要的基础研究建立在 PCBC 基础设施和其他基础设施之上的转化研究和技能开发通过社交媒体扩展我们的基础设施将是巨大的。