Child Health Research Center

儿童健康研究中心

• 批准号: 10300437
• 负责人: GARY ARTHUR SILVERMAN
• 金额: $ 42.52万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-03-01 至 2022-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10300437
• 关键词: 2 year old; Area; Basic Science; Benchmarking; Bioinformatics; Biology; Cellular biology; Child Health; Child Support; Childhood; Core Facility; Cryoelectron Microscopy; DNA sequencing; Development; Developmental Biology; Discipline; Disease; Doctor of Medicine; Doctor of Philosophy; Faculty; Feedback; Fostering; Funding; Generations; Genetic; Genomics; Goals; Human; Image; Immunology; Investigation; Knowledge; Laboratories; Leadership; Medical center; Mentors; Pathway interactions; Physicians; Play; Research; Research Personnel; Role; SECTM1 gene; Scientist; Systems Biology; Training; Underrepresented Minority; Universities; Washington; Woman; animal model development; base; biomedical resource; career development; developmental disease; exome; experience; genome editing; improved; live cell imaging; medical schools; next generation; pediatric department; programs; responsible research conduct; role model; statistics; whole genome

Project Summary Abstract This renewal application (RFA-HD-18-011) is for support of the Child Health Research Center (CHRC) at Washington University School of Medicine. Pediatric physician-scientists play a crucial role in advancing knowledge that improves child health. To meet the ongoing national need to replenish the pediatric physician-scientist pipeline at the junior faculty level, our program supports a mentored career development pathway for 3 Scholars per year for 2-3 years by leveraging a wealth of biomedical resources within the Washington University School of Medicine and the Medical Center campus. As we have done for the past 22 years, the long-term objective of our Center is to develop Scholars that focus their research efforts on Pediatric disease-oriented biology by applying recent advances in the basic sciences, such as developmental biology, cell biology, immunology, genetics/genomics, and systems biology. The specific aims of this proposal include: 1) protected mentored research experiences with well-established investigators encompassing a wide range of disciplines within the Washington University School of Medicine and the Department of Pediatrics, 2) obligatory educational programs in laboratory management, scientific rigor, statistics, grantsmanship and responsible conduct of research, 3) individualized specific coursework based on the Scholars’ areas of investigation (e.g., bioinformatics, live-cell imaging), 4) continuous feedback to the Scholars, mentors and CHRC leadership, and 5) foster the development of Scholars who are women and underrepresented minorities. The program, now twenty-two years old, has a stellar track record by exceeding national benchmarks (”K12 to K08/23” conversion rate of 63% and an outstanding “K to R conversion” rate of 59%; national average <40%, respectively), and will ultimately close the knowledge gap between basic scientists and pediatric clinicians. Gary A. Silverman, M.D., Ph.D. will serve as Program Director, and David Hunstad, M.D. will serve as Training Director. The CHRC and its Scholars will continue to utilize our institutionally-funded state-of-art core facilities that provide, for example, whole genome/exome DNA sequencing, bioinformatics, cryo-EM imaging, genome editing and model animal development, to facilitate the study of Pediatric disease states. The long-term goals of the CHRC are being realized as its Scholars contribute to our understanding of human developmental diseases for decades to come, while evolving into the next generation of scientific leaders, role models and mentors for subsequent generations of Pediatric Scholars.

项目摘要摘要 此更新应用程序（RFA-HD-18-011）是为了支持儿童健康研究中心 （CHRC）华盛顿大学医学院。小儿身体科学家发挥着重要的作用 在提高改善儿童健康的知识方面的角色。满足持续不断的国家需求 在初级教师级别补充小儿身体科学家管道，我们的计划支持 通过利用丰富的财富，每年3年的职业发展途径为2 - 3年 华盛顿大学医学院和医学中心的生物医学资源 校园。正如我们在过去22年中所做的那样，我们中心的长期目标是发展 通过应用最近 基础科学的进步，例如发育生物学，细胞生物学，免疫学， 遗传学/基因组学和系统生物学。该提案的具体目的包括：1）受保护 与成熟的研究人员一起进行的研究经验，包括广泛的 华盛顿大学医学院和儿科系的学科，2） 实验室管理，科学严谨，统计，授予技巧的强制性教育计划 和负责任的研究，3）基于学者的个性化特定课程 投资领域（例如，生物信息学，现场电池成像），4）对学者的持续反馈， 导师和CHRC领导，以及5）促进妇女学者的发展以及 代表性不足的少数民族。该节目现已二十二年，拥有出色的往绩记录 超过国家基准（“ K12至K08/23”的转换率为63％，而“ K到R） 转换率”为59％；全国平均水平<40％），最终将关闭 基本科学家与儿科临床医生之间的知识差距。 Gary A. Silverman，医学博士，博士将要 担任计划总监，医学博士David Hunstad将担任培训主任。 CHRC和 它的学者将继续利用我们提供的机构资助的最新核心设施，这些设施为 例如，整个基因组/外显子组DNA测序，生物信息学，冷冻EM成像，基因组编辑 并建模动物发展，以促进小儿疾病状态的研究。长期目标 由于学者有助于我们对人类的理解，因此正在实现CHR。 发育疾病几十年来，同时发展成为下一代的科学疾病 后来的儿科学者的领导者，榜样和导师。