Duke Cancer Health Disparities P20 SPORE

杜克大学癌症健康差异 P20 SPORE

基本信息

批准号：
10037506
负责人：
STEVEN R PATIERNO
金额：
$ 110.47万
依托单位：
DUKE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-09-14 至 2023-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10037506
关键词：
Address African African American Age Alternative Splicing Antibody Response Area Basic Science Bioinformatics Biological Biology Biometry Caring Catchment Area Clinical Collaborations Communication Communities Complex Data Development Diagnosis Disease Doctor of Philosophy Early Diagnosis Ensure Environment Environmental Health Epidemiology European Evaluation Event Exhibits Feeds Foundations Funding Future Gastric Intraepithelial Neoplasia Gastric Metaplasia Genotype Goals Health Health system Helicobacter pylori Immune response Incidence Infrastructure Institutes Intercept Leadership Life Style Malignant Neoplasms Malignant neoplasm of lung Non-Small-Cell Lung Carcinoma Not Hispanic or Latino Outcome Pathology Patients Pilot Projects Population Preparation Prevention Prevention strategy Program Research Project Grants RNA Splicing Race Research Research Design Research Personnel Research Project Grants Resource Sharing Resources Scientist Seeds Services Smoking Status Specimen Structure Subgroup Therapeutic Therapeutic Intervention Translating Translational Research Virulence Factors Work base biobank cancer care cancer health disparity clinical translation clinically relevant cohort disparity reduction gastric carcinogenesis health equity improved in vitro Model individualized prevention innovation malignant stomach neoplasm mortality mortality disparity novel novel strategies population based precision oncology premalignant programs psychosocial racial difference screening social survivorship therapeutic target translational impact

项目摘要

ABSTRACT – Overall Cancer health disparities span the continuum of cancer care, including prevention, screening, early detection, diagnosis, interception, treatment and survivorship, and are driven by a complex interplay between social, psycho-social, lifestyle, environmental, structural, and biological determinants of health. This Duke Cancer Health Disparities (DCHD) P20 SPORE application evolved from institutional efforts to address this complex, multi-level problem, and represents the work of a group of basic, translational, clinical and population scientists working collaboratively and synergistically to address disparities at particular points in the cancer disparity continuum, while recognizing the complexities of the larger problem of achieving cancer health equity. Our OVERALL GOAL is to develop or improve new or existing interventions and therapies through a better understanding of cancer disparities prevalent in the Duke Cancer Institute’s catchment area. We propose the following Aims: provide the infrastructure, oversight, and resources to conduct innovative translational research to reduce cancer disparities through two projects focused on under-studied disparities (Aim 1); ensure availability of expert support through Administrative and Shared Resource Cores (Aim 2); seed Developmental Research Program (DRP) projects and grow the cancer disparities research community (Aim 3); and complete planning and transition activities in preparation of a P50 SPORE application, including participating in and leading inter- SPORE activities (with other P20s and with P50 SPOREs) that enhance our collective impact (Aim 4). We propose two Projects. Project 1 is entitled “Race-related RNA splicing in non-small cell lung cancer: functional interrogation and therapeutic targeting”. Project 2 is entitled “Racial differences in host immune response and gastric carcinogenesis: translating underlying biology to promote gastric cancer interception”. Our two P20 Projects will be supported by an Administrative Core, a Biospecimen/Pathology Core (Core 1), and a Biostatistics and Bioinformatics Core (Core 2). DRP projects funded by the P20 may graduate into full projects for the future P50 SPORE. The expected outcomes of these aims are to conduct groundbreaking research in cancer health disparities, to develop novel approaches to mitigate these disparities, and to prepare and submit a full DCHD P50 SPORE application for the continuation and expansion of these efforts.

摘要——总体癌症健康差异贯穿癌症护理的整个过程，包括预防、筛查、早期发现、诊断、拦截、治疗和生存，并由社会、健康的社会心理、生活方式、环境、结构和生物决定因素。健康差异 (DCHD) P20 SPORE 应用程序是从机构努力发展而来的，旨在解决这一复杂的问题，多层次的问题，代表了一组基础科学家、转化科学家、临床科学家和人口科学家的工作协作和协同努力解决癌症差异中特定点的差异连续体，同时认识到实现癌症健康公平这一更大问题的复杂性。总体目标是通过更好的方法开发或改进新的或现有的干预措施和疗法了解杜克癌症研究所辖区普遍存在的癌症差异。以下目标：提供基础设施、监督和资源以进行创新转化研究通过两个针对未充分研究的差异的项目来减少癌症差异（目标 1）；通过管理和共享资源核心提供专家支持（目标 2）；计划 (DRP) 项目并发展癌症差异研究社区（目标 3）并完成规划；准备 P50 SPORE 应用程序的过渡活动，包括参与和领导国际合作 SPORE 活动（与其他 P20 和 P50 SPORE）增强我们的集体影响力（目标 4）。提出两个项目。项目1的标题是“非小细胞肺癌中的种族相关RNA剪接：功能性”。审讯和治疗靶向”项目 2 的标题是“宿主免疫反应和治疗中的种族差异”。胃癌发生：转化基础生物学以促进胃癌拦截”。项目将由行政核心、生物样本/病理学核心（核心 1）和 P20 资助的生物统计学和生物信息学核心（核心 2）项目可能会全面毕业。未来P50 SPORE项目的预期成果是进行突破性的。研究癌症健康差异，开发新方法来减轻这些差异，并做好准备并提交完整的 DCHD P50 SPORE 申请以继续和扩大这些努力。