Research Project

研究项目

• 批准号: 8033964
• 负责人: Cathy D. Meade
• 金额: $ 51.41万
• 依托单位: H. LEE MOFFITT CANCER CTR & RES INST
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2015-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8033964
• 关键词: Address; Age; Awareness; Clinic; Colorectal Cancer; Communities; Education; Educational Intervention; Fecal occult blood; Federally Qualified Health Center; Foundations; Health; Individual; Intervention; Intervention Studies; Malignant Neoplasms; Mediating; Minority Groups; Modeling; Pamphlets; Patients; Phase; Preventive; Provider; Randomized; Readiness; Recruitment Activity; Regression Analysis; Research; Research Project Grants; Risk; Screening for cancer; Screening procedure; Testing; Woman; aged; arm; base; colorectal cancer screening; community based participatory research; cost effectiveness; design; health literacy; improved; innovation; intervention effect; medically underserved population; men; prospective; racial and ethnic; theories; tool; uptake

Project Summary: The disproportionate burden of CRC persists among racial-ethnic minorities and other medically underserved populations despite increased availability of beneficial screening tests. To address this gap, we propose an innovative theory-based educational intervention delivered in federally qualified health centers and health department clinics to improve patient awareness about colorectal cancer screening (CRCS), facilitate patient-provider discussion of CRCS, and increase uptake of CRCS among average risk individuals. We build on our established community-academic partnerships and the community-based participatory research framework as the foundation for a two-phase project entitled "Colorectal Cancer Awareness, Research, Education and Screening" (CARES). The aim of Phase 1 (year 1) is to design and produce a CARES toolkit consisting of a DVD and photonovella booklet, screening readiness card, and reminder postcard intended for a diverse medically underserved population. A total of 107 individuals will take part in the formative research, which uses a health literacy framework as a basis for developing the educational tool kit. In Phase 11 (Years 2-5), the aims ofthe prospective, longitudinal, randomized communitybased intervention study are to: assess efficacy of CARES tool kit vs. a standard brochure intervention (SI) on CRCS uptake; assess whether Preventive Health Model variables mediate intervention effects; and examine cost-effectiveness. In this phase, a total of 420 men and women aged 50-75 years, will be recruited and randomized to either the CARES condition or SI (210 in each arm). Both groups will receive free immunochemical fecal occult blood test (1-FOBT) kits as part of the intervention. I-FOBT and overall (any test) screening uptake will be evaluated at 12 months and compared between conditions. It is expected that the CARES intervention will be associated with greater screening uptake (FOBT and other screening) and cost effectiveness that the SI condition. Multivariable regression analysis will be used to assess factors associated with intervention effects.

项目摘要：尽管有益筛查测试的可用性有所增加，但在少数族裔和其他医疗服务不足的人群中，结直肠癌的负担仍然不成比例。为了弥补这一差距，我们建议在联邦合格的卫生中心和卫生部门诊所提供一种基于理论的创新教育干预措施，以提高患者对结直肠癌筛查 (CRCS) 的认识，促进患者与提供者对 CRCS 的讨论，并提高患者对 CRCS 的接受度。平均风险 个人。我们以已建立的社区学术伙伴关系和基于社区的参与性研究框架为基础，作为题为“结直肠癌意识、研究、教育和筛查”(CARES) 的两阶段项目的基础。第一阶段（第一年）的目标是设计和制作一个 CARES 工具包，其中包括 DVD 和照片小说小册子、筛查准备卡和提醒明信片，旨在服务于医疗服务不足的多元化人群。共有107人参加 参与形成性研究，该研究使用健康素养框架作为开发教育工具包的基础。在第 11 阶段（第 2-5 年），前瞻性、纵向、随机社区干预研究的目的是： 评估 CARES 工具包与标准手册干预 (SI) 对 CRCS 吸收的功效；评估预防健康模型变量是否介导干预效果；并检查成本效益。在此阶段，将招募总共 420 名 50-75 岁的男性和女性，并随机分配到 CARES 条件或 SI（每组 210 人）。作为干预措施的一部分，两组患者都将获得免费的免疫化学粪便潜血检测 (1-FOBT) 试剂盒。 I-FOBT 和整体（任何测试） 筛查吸收率将在 12 个月时进行评估，并在不同条件下进行比较。预计与 SI 条件相比，CARES 干预措施将带来更高的筛查率（FOBT 和其他筛查）和成本效益。多变量回归分析将用于评估与干预效果相关的因素。