Core B: Pathology Core

核心 B：病理学核心

• 批准号: 10006527
• 负责人: Giorgio Inghirami
• 金额: $ 21.39万
• 依托单位: WEILL MEDICAL COLL OF CORNELL UNIV
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-18 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10006527
• 关键词: Academic Medical Centers; Adherence; Archives; Biological; Biopsy; CD19 gene; Cell Cycle; Cell Separation; Cell Survival; Cells; Clinical; Clinical Data; Clinical Trials; Collaborations; Complement; Cytogenetic Analysis; Data; Databases; Diagnosis; Diagnostic; Ensure; Flow Cytometry; Government; Hematologist; Image Analysis; Immunohistochemistry; In Vitro; Individual; Institution; Institutional Review Boards; Internet; Intervention; Left; Liquid substance; Lymphoma cell; Malignant Neoplasms; Mantle Cell Lymphoma; Medicine; Methods; Molecular Target; Morphology; Mus; Ohio; Pathology; Patients; Pharmacotherapy; Process; Protocols documentation; Quality Control; Research Personnel; Sampling; Scientist; Secure; Services; Solid; Specimen; Speed; Stains; Surgeon; System; Technical Expertise; Testing; Time; Tissue Banks; Tissue Microarray; Tissue Procurements; Tissues; Update; base; clinical diagnostics; design; digital imaging; good laboratory practice; individual patient; magnetic beads; mouse model; multidisciplinary; novel therapeutics; outcome forecast; patient population; preservation; programs; radiologist; repository; research and development; success; symposium; tissue resource; translational study

SUMMARY The primary purposes of the pathology core will be: procure patient specimens, characterize and assess the specimens as required by projects and for clinical trials, provide data to the projects and other cores, bank tissue, and distribute tissue to the projects. Our current and past efforts have shown that the centralization of specimens, analysis, and data provided by the core facilitates collaboration between other cores and projects. For example, whereas individual projects might be able to provide some of these services for themselves, centralization provides a degree of consistency and reliability that enables the confident exchange of parallel information, derived from methods with a level of quality control that could not be achieved outside of a dedicated core. Also, because we have already derived methods tailored to the needs of similar projects, we are uniquely suited to devise or revise systems as needed to provide services. Because mantle cell lymphoma (MCL) is an uncommon cancer, the combination of the Ohio State University Medical Center (OSUMC) and Weill Cornell Medicine (WCM) tissue resources are critical to the success of this PPG. We have designed these services to optimize the use of our two centers, while keeping overlap to a minimum. The unique expertise of WCM and that of OSUMC complement each other, resulting in a breadth of services that would not be possible on any single campus. !

概括 病理学核心的主要目的是：获取患者标本、表征和评估 根据项目和临床试验所需的标本，向项目和其他核心、银行提供数据 组织，并将组织分发给项目。我们当前和过去的努力表明，集中化 核心提供的样本、分析和数据促进了其他核心和项目之间的协作。 例如，虽然单个项目可能能够为自己提供其中一些服务， 集中化提供了一定程度的一致性和可靠性，使并行的自信交换成为可能 信息，源自具有一定质量控制水平的方法，而这些质量控制水平在外部无法实现 专用核心。此外，由于我们已经根据类似项目的需求导出了方法，因此我们 特别适合根据提供服务的需要设计或修改系统。因为套细胞淋巴瘤 (MCL) 是一种罕见的癌症，由俄亥俄州立大学医学中心 (OSUMC) 和 威尔康奈尔医学 (WCM) 的组织资源对于本次 PPG 的成功至关重要。我们设计了 这些服务可以优化我们两个中心的使用，同时将重叠保持在最低限度。独特的 WCM 的专业知识与 OSUMC 的专业知识相辅相成，从而提供广泛的服务， 在任何一个校园都不可能实现。 ！