FASEB SRC on Genetic Recombination and Genome Rearrangements

FASEB SRC 关于基因重组和基因组重排

• 批准号: 8199893
• 负责人: John HJ Petrini
• 金额: $ 0.45万
• 依托单位: FEDERATION OF AMER SOC FOR EXPER BIOLOGY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-01 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8199893
• 关键词: American; Arabidopsis; Ataxia Telangiectasia; BRCA1 gene; BRCA2 Protein; BRCA2 gene; Bacteria; Biological; Biological Models; Biology; Bloom Syndrome; Caenorhabditis elegans; Chromosomes; Colorado; DNA Repair; DNA Sequence Rearrangement; Defect; Disease; Double Strand Break Repair; Drosophila genus; Equilibrium; Genetic; Genetic Recombination; Genome; Genome Stability; Goals; Hereditary Breast Carcinoma; Human; Information Technology; Inherited; Life; Malignant Neoplasms; Mammals; Mutate; Nijmegen Breakage Syndrome; Organism; Participant; Pathway interactions; Play; Principal Investigator; Proteins; Research Personnel; Resistance; Role; Series; Societies; Syndrome; System; Techniques; Work; Xenopus; Yeasts; biological systems; environmental mutagens; homologous recombination; malignant breast neoplasm; new technology; programs; recombinational repair; symposium; unpublished works

DESCRIPTION (provided by applicant): This application seeks partial support for the Federation of American Societies of Experimental Biology (FASEB) conference on Genetic Recombination and Genome Rearrangements to be held July 24-29, 2011 in Steamboat Springs, Colorado. The 2011 Conference on Genetic Recombination and Chromosome Rearrangements will be the fourteenth in a series of highly successful bi-annual conferences devoted to these topics. This conference aims to join investigators studying many diverse aspects of genetic recombination, in a range of biological systems and with different experimental approaches. Presentations will introduce new and unpublished work on timely questions in the field and will include discussion from all participants. The FASEB conference provides unique opportunities for the exchange of information and technology that can be appreciated and exploited across the recombination field. Recombination plays an important role in the control of genetic stability in human as well as all other living organisms. The discovery that several human cancer prone syndromes, for example, Ataxia Telangiectasia (A-T), Nijmegen Breakage Syndrome (NBS) and A-T like disorder (A-TLD), are caused by defects in double-strand break repair has highlighted the importance of this pathway in maintaining genome integrity and cancer avoidance. Furthermore, the product of the BRCA2 gene, which is mutated in a subset of hereditary breast cancers, interacts directly with Rad51 and is essential for homologous recombination. Many of the invited speakers will discuss the role of proteins defective in these human cancer prone syndromes in genome stability and resistance to environmental mutagens. To inform and augment studies from mammals, work concerning related proteins and mechanisms from model systems of bacteria, yeast, Arabidopsis, Drosophila, C. elegans and Xenopus will be featured. Much of the conference will be devoted to topics of concern to the National Cancer. PUBLIC HEALTH RELEVANCE: DNA repair by homologous recombination plays an important role in the control of genetic stability in all living organisms. The discovery that several human cancer prone syndromes, for example, Ataxia Telangiectasia (A-T), hereditary forms of breast cancer (BRCA1 or BRCA2) and Bloom's syndrome are caused by defects in the DNA recombination/repair has highlighted the importance of this pathway in maintaining genome integrity and cancer avoidance. This conference brings together the principal investigators studying the mechanisms of recombination with the goal of further understanding how recombination contributes to genome stability.

描述（由申请人提供）：本申请寻求对将于 2011 年 7 月 24 日至 29 日在科罗拉多州斯廷博特斯普林斯举行的美国实验生物学会联合会 (FASEB) 基因重组和基因组重排会议的部分支持。 2011 年基因重组和染色体重排会议将是一系列非常成功的两年一度的专门讨论这些主题的会议中的第十四次会议。本次会议旨在与研究人员一起，在一系列生物系统中采用不同的实验方法研究基因重组的许多不同方面。演讲将介绍有关该领域及时问题的新的和未发表的工作，并将包括所有参与者的讨论。 FASEB 会议为交流信息和技术提供了独特的机会，这些信息和技术可以在重组领域得到欣赏和利用。 重组在人类以及所有其他生物体的遗传稳定性控制中发挥着重要作用。一些人类易患癌症的综合征，例如共济失调毛细血管扩张症 (A-T)、奈梅亨断裂综合征 (NBS) 和 A-T 样疾病 (A-TLD) 是由双链断裂修复缺陷引起的这一发现凸显了这一点的重要性维持基因组完整性和避免癌症的途径。此外，BRCA2 基因的产物（在遗传性乳腺癌的一个子集中发生突变）可直接与 Rad51 相互作用，并且对于同源重组至关重要。许多受邀演讲者将讨论这些人类癌症易发综合征中缺陷蛋白质在基因组稳定性和对环境诱变剂的抵抗力中的作用。为了为哺乳动物的研究提供信息和加强，有关细菌、酵母、拟南芥、果蝇、线虫和爪蟾模型系统的相关蛋白质和机制的工作将成为特色。会议的大部分内容将专门讨论国家癌症中心关注的话题。 公共卫生相关性：通过同源重组进行的 DNA 修复在控制所有生物体的遗传稳定性方面发挥着重要作用。一些人类癌症易发综合征，例如共济失调性毛细血管扩张症 (A-T)、遗传性乳腺癌（BRCA1 或 BRCA2）和布卢姆综合征是由 DNA 重组/修复缺陷引起的这一发现，强调了该途径在维持基因组完整性和癌症避免。这次会议汇集了研究重组机制的主要研究人员，目的是进一步了解重组如何促进基因组稳定性。