2011 Epigenetics Gordon Research Conference

2011年表观遗传学戈登研究会议

基本信息

批准号：
8191704
负责人：
MARISA S. BARTOLOMEI
金额：
$ 2.1万
依托单位：
GORDON RESEARCH CONFERENCES
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-07-05 至 2012-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8191704
关键词：
Affect Aging Amaze Animal Model Area Basic Science Biological Models Biological Phenomena Cells Chromatin Chromosomes Cues DNA DNA Methylation DNA Transposable Elements Development Developmental Biology Diet Disease Environment Epigenetic Process Equilibrium Essential Genes Ethnic group Eukaryota Explosion Female Functional RNA Funding Gene Dosage Gene Expression Gene Expression Regulation Genes Genetic Genome Genomics Health Hearing Histones Human Indiana Inherited Insecta International Investigation Knowledge Link Malignant Neoplasms Mammals Mediating Mediator of activation protein Memory Methodology Modification Molecular Natural Selections Nuclear Nuclear RNA Oral Organism Participant Pathway interactions Pennsylvania Personal Satisfaction Plants Positioning Attribute Post-Translational Protein Processing Postdoctoral Fellow Principal Investigator Prokaryotic Cells Published Comment RNA RNA Interference Recruitment Activity Regulation Research Research Personnel Rett Syndrome Role Science Scientist Series Somatic Cell Students Study models System Time Toxic Environmental Substances Tumor Suppressor Genes Underrepresented Minority Universities Variant Woman Work X Chromosome X Inactivation abstracting age effect base biological research biological systems cancer therapy career chromatin modification dosage epigenomics fungus genome sequencing human disease imprint induced pluripotent stem cell infancy innovation meetings member offspring posters protein complex racial and ethnic response symposium technology development transmission process

项目摘要

DESCRIPTION (provided by applicant): In this application, we seek funding for the partial support of the 2011 Gordon Research Conference (GRC) on Epigenetics, one of the most exciting and active areas of biological research today. An explosion of epigenetics research in the past decade reflects the fact that knowledge of complete genome sequences is not sufficient to understand how genomic information is decoded or regulated. Chromosomes are not naked DNA molecules, but DNA-protein complexes known as chromatin. Modification of the chromatin by DNA methylation, post- translational modification of the histones that wrap the DNA, use of alternative histone variants and alterations in histone spacing and chromatin compaction are common aspects of epigenetic regulation throughout eukaryotes. As a result, studies of model organisms have direct relevance to humans and human disease states. Meeting every two years since 1995, the Epigenetics GRC has earned a strong international reputation as the premier meeting in its field, typically drawing more applicants than can be accepted. The conference is known for its cutting edge science and breadth of coverage, providing a forum for the exploration of a wide range of epigenetic phenomena and epigenetic regulatory mechanisms in numerous model organisms, as well as humans. Basic science studies of such intriguing phenomena as X chromosome inactivation, gametic imprinting, position effect variegation, gene dosage control, paramutation, nucleolar dominance, transposon silencing and RNA-mediated DNA methylation will be balanced with medically-relevant research, including the epigenetics of cancer, imprinting disorders, aging, memory and effects of the environment (including diet). The 2011 conference will be co-chaired by mammalian biologist Marisa Bartolomei (University of Pennsylvania), and plant biologist Craig Pikaard (Indiana University), both leaders in the field of epigenetics and long time Epigenetics GRC participants. The 2011 Epigenetics GRC will include a mix of invited established investigators who are leaders in the field, invited young investigators who are doing exciting work and young scientists whose submitted abstracts indicate new breakthroughs at the cutting edge of the field. In this way, the organizers will strive to promote the careers of students, postdoctoral fellows, and new principal investigators, by involving them in both the oral and poster presentations. Special efforts will also be made to support women scientists and include participants who are members of racial/ethnic groups that are underrepresented in science. PUBLIC HEALTH RELEVANCE: Epigenetic regulation is essential for development, controlling such phenomena as inactivation of one X chromosome in somatic cells of female mammals, dictating the whether only maternally or paternally inherited copies of specific genes are expressed in offspring, maintaining transposable elements in a silenced state, or controlling the dosage of repetitive essential genes. Epigenetic misregulation contributes to cancer through silencing of tumor suppressor genes. Disease states including imprinting disorders and Rett syndrome have an epigenetic basis, as do aspects of aging and effects of diet or environmental toxins on gene expression. By advancing the study of epigenetic mechanisms, the Epigenetics Gordon Research Conference will contribute to the understanding and improvement of human health and well-being.

描述（由申请人提供）：在本申请中，我们寻求资助2011年戈登研究会议（GRC）关于表观遗传学的部分支持，这是当今生物学研究中最令人兴奋和最活跃的领域之一。在过去的十年中，表观遗传学研究的爆炸反映了以下事实：完整基因组序列的知识不足以了解基因组信息如何被解码或调节。染色体不是裸体DNA分子，而是称为染色质的DNA-蛋白质复合物。通过DNA甲基化修饰染色质，包裹DNA的组蛋白的翻译后修饰，使用替代组蛋白变异以及组蛋白间距的改变和染色质质量压实的改变是整个真核生物的表观遗传调节的常见方面。结果，模型生物的研究与人类和人类疾病状态有直接相关。自1995年以来，表观遗传学GRC每两年开会一次，作为其领域的主要会议，赢得了国际声誉，通常吸引比接受更多的申请人。该会议以其前沿科学和覆盖范围广度而闻名，为探索许多模型生物以及人类中广泛的表观遗传现象和表观遗传调节机制提供了论坛。诸如X染色体灭活，配子烙印，位置效应，基因剂量控制，参数，参数，核酸占主导地位，转孔沉默和RNA介导的DNA甲基化等有趣现象的基础科学研究将与医学上利益方面的研究平衡，包括癌症，包括癌症，融合型的环境（包括癌症），将与癌症进行融合，并将其融合（包括对环境）的融合，并将其融合。 2011年的会议将由哺乳动物生物学家Marisa Bartolomei（宾夕法尼亚大学）和植物生物学家Craig Pikaard（印第安纳大学）共同主持，这都是表观遗传学和长期表观基因眼镜的参与者的领导者。 2011年的表观遗传学GRC将包括一系列受邀成熟的调查员，他们是该领域的领导者，邀请年轻的调查人员正在从事令人兴奋的工作，而年轻的科学家则提交摘要表明在该领域的最先进。这样，组织者将努力通过使他们参与口头和海报演讲来促进学生，博士后研究员和新的主要调查员的职业。还将做出特别的努力来支持女性科学家，并包括参与者，这些参与者是科学领域不足的种族/族裔群体成员。公共卫生相关性：表观遗传调节对于开发至关重要，控制着女性哺乳动物体细胞中一个X染色体的现象，这决定了仅在孕产物或亲子遗传的特定基因的副本中表达的，在后代中表达出来，在沉默的状态中维持可替代的基因或控制良好的基因的可转移元素。表观遗传上的正调通过沉默抑制肿瘤基因会导致癌症。包括印记疾病和RETT综合征在内的疾病状态具有表观遗传基础，饮食或环境毒素对基因表达的衰老和影响方面也是如此。通过促进表观遗传机制的研究，戈登研究会议的表观遗传学将有助于理解和改善人类健康和福祉。