Environmentally Triggered Neurodevelopmental Disorders: Focus on Endocrine Disrup

环境引发的神经发育障碍：关注内分泌紊乱

• 批准号: 8257471
• 负责人: Joan Marie Cranmer
• 金额: $ 2.5万
• 依托单位: UNIV OF ARKANSAS FOR MED SCIS
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-15 至 2012-09-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8257471
• 关键词: Address; Androgens; Animals; Arkansas; Attention deficit hyperactivity disorder; Autistic Disorder; Award; Awareness; Basic Science; Central Nervous System Diseases; Chemicals; Child; Clinical; Clinical Research; Collaborations; Communication; Communities; Complex; Copy Number Polymorphism; Data; Diagnosis; Diagnostic; Disease; Educational workshop; Endocrine; Endocrine Disruptors; Endocrine disruption; Endocrine system; Environment; Environmental Health; Environmental Risk Factor; Epidemiologist; Epidemiology; Epilepsy; Estrogens; Event; Experimental Designs; Exposure to; Fingers; Food; Fostering; Gene Mutation; Genetic Polymorphism; Goals; High Prevalence; Hormones; Human; Human Milk; Immune; Impairment; Interdisciplinary Study; International; Intervention; Investigation; Journals; Link; Mediating; Medical; Medicine; Mentors; Metals; Methods; Neurodevelopmental Disorder; Nutritional status; Paper; Participant; Peer Review; Postdoctoral Fellow; Predisposition; Prevalence; Public Health; Publications; Published Comment; Publishing; Research; Research Personnel; Risk; Risk Assessment; Risk Factors; Role; Schizophrenia; Science; Scientist; Series; Sex Bias; Sex Characteristics; Signal Transduction; Structure; Students; Symptoms; Thinking; Thyroid Gland; Time; Tissues; Touch sensation; Universities; Work; Xenobiotics; abstracting; boys; clinically significant; college; critical period; design; environmental stressor; indexing; interdisciplinary collaboration; male; meetings; multidisciplinary; neonate; nervous system disorder; neurodevelopment; neurotoxicology; novel; novel strategies; pediatric department; policy implication; pollutant; posters; pre-doctoral; professor; programs; public health relevance; social; social implication; special interest group; symposium; trend

DESCRIPTION (provided by applicant) The 27th meeting in the International Neurotoxicology Conference Series (NEUROTOX 27) will address the theme of "Environmentally Triggered Neurodevelopmental Disorders: Focus on Endocrine Disruption and Sex Differences in Autism, ADHD, and Schizophrenia". NEUROTOX 27 will convene October 30 to November 2, 2011 at the Sheraton Imperial Hotel and Conference Center in Research Triangle Park, NC. Each conference in the series is devoted to a timely, forward-thinking theme that has significant impact on environmental health and neurological disorders, and there exists enough evidence that the science on the theme will be advanced by being scrutinized in this established, multidisciplinary, focused, program approach. To be at the forefront of science the conference chair partners with internationally-recognized scientific experts on the focused theme to co-organize the meeting and identify the session themes, topics and speakers. This year the meeting will be highly focused on two endpoints: 1) endocrine disruption and 2) sex differences, in three complex neurodevelopmental disorders which have factors in common: 1) autism, 2) ADHD and 3) schizophrenia. The plenary sessions have been structured to present the latest clinical and basic research in a format that will facilitate discussion, address specific questions (published in the Program) and be conducive to a cross-cutting discussion on common factors on the last day of the conference after evidence has been presented. Significance: Clinical disorders of the central nervous system arise from complex interactions among multiple risk factors. Genetic mutations, polymorphisms, and copy number variations confer heritable susceptibility to environmental stressors including exposures to xenobiotic chemicals, shifts in nutritional status, and medical interventions. The prevalence of autism has increased dramatically and there is emerging evidence that suggests increases in the diagnosis of ADHD and schizophrenia. Although some of these trends can be explained by increased awareness, diagnostic drift and changes in diagnostic criteria, environmental factors are likely contributors. An increasing number of persistent organic pollutants (POPs) and metals have been shown to alter endocrine signaling mediated by thyroid, estrogen and androgen hormones. Many of these chemicals are detected in maternal and gestational tissues, breast milk, and neonates at levels of concern. The consequences of endocrine disruption during critical periods of neurodevelopment have far-reaching implications. NEUROTOX 27 will present the latest evidence and controversies linking endocrine disruption and neurodevelopmental disorders, with a focus on autism, ADHD, and schizophrenia. These 3 disorders share several clinical features including strong gender bias, immune impairments, and an association with seizure disorders. Yet these disorders differ in onset of clinical symptoms that may provide clues to critical windows of susceptibility to specific endocrine disruptors and their underlying mechanisms. The conference is designed to present attendees with the latest state-of-the-science about the role of the endocrine system in environmentally triggered disorders and stimulate vigorous discussion among experts from different backgrounds to help advance the science related to the theme. Public Health Relevance: The public health relatedness of this application is that the results of this conference will help us better understand the role of the environment, endocrine disruption, and sex differences in autism, ADHD and schizophrenia. NEUROTOXICOLOGY 27 will convene internationally recognized experts to present the latest evidence and controversies linking endocrine disruption and environmentally triggered neurodevelopmental disorders, with a focus on autism, ADHD, and schizophrenia. The public health impact of these disorders is enormous. Today, one in 110 children (and one in 70 boys) born in the U.S. is diagnosed with autism, and the numbers have been rising 10% to 17% a year. Autism has a range of features that suggest the possibility of endocrine-related alterations, including a much higher prevalence in males. Other clinical clues invite critical investigation of potential toxicological, immune and endocrine disruptive contributors to autism, ADHD and schizophrenia. Peer-reviewed papers from NEUROTOXICOLOGY 27 will be published rapidly, disseminated internationally, and made accessible online to readily reach target audiences.

描述（由申请人提供） 国际神经毒理学会议系列（Neurotox 27）的第27届会议将介绍“环境触发的神经发育障碍：专注于自闭症，ADHD和精神分裂症的内分泌干扰和性别差异”的主题。 Neurotox 27将于2011年10月30日至11月2日在北卡罗来纳州研究三角公园的Sheraton Imperial Hotel and Conference Center举行。 该系列中的每次会议都致力于及时，具有前瞻性的主题，对环境健康和神经系统疾病产生重大影响，并且存在足够的证据表明，在这种既定，多学科的，专注的，专注的，计划的方法中，都将通过审查该主题的科学。为了成为科学的最前沿，会议主席与国际认可的科学专家有关集中主题的科学专家，以共同组织会议并确定会议主题，主题和演讲者。今年，会议将高度关注两个终点：1）内分泌干扰和2）性别差异，在三种复杂的神经发育障碍中，具有共同因素：1）自闭症，2）ADHD和3）精神分裂症。全体会议的结构化旨在以一种促进讨论的格式提出最新的临床和基础研究，以解决特定问题（在计划中发表），并有利于在会议的最后一天进行有关共同因素的跨裁切讨论，此前证据呈现了证据。 意义：中枢神经系统的临床疾病是由多种危险因素之间复杂的相互作用引起的。 遗传突变，多态性和拷贝数变化具有可赋予环境压力源的敏感性，包括对异种生物化学物质的暴露，营养状况的转移和医疗干预措施。自闭症的患病率急剧增加，并有新的证据表明ADHD和精神分裂症的诊断增加。尽管这些趋势中的某些趋势可以通过提高的认识，诊断漂移和诊断标准的变化来解释，但环境因素可能是贡献者。 越来越多的持续有机污染物（POP）和金属已显示可改变由甲状腺，雌激素和雄激素激素介导的内分泌信号传导。 这些化学物质中的许多化学物质都在母体和妊娠组织，母乳和新生儿中以关注程度检测到。内分泌干​​扰在神经发育期间的后果具有深远的影响。 Neurotox 27将介绍将内分泌干扰和神经发育障碍联系起来的最新证据和争议，重点是自闭症，ADHD和精神分裂症。这三种疾病具有多种临床特征，包括强烈的性别偏见，免疫障碍以及与癫痫发作疾病的关联。然而，这些疾病在临床症状的发作上有所不同，这些疾病可能为特定内分泌干扰物及其基本机制的关键窗口提供了线索。该会议旨在向与会者展示有关内分泌系统在环境触发疾病中的作用的最新水平，并激发来自不同背景的专家之间的激烈讨论，以帮助推进与主题相关的科学。 公共卫生相关性：本申请的公共卫生相关性是，本次会议的结果将帮助我们更好地了解环境的作用，内分泌干扰以及自闭症，ADHD和精神分裂症的性别差异。神经毒理学27将召集国际公认的专家，提出有关内分泌干扰和环境引发的神经发育障碍的最新证据和争议，重点是自闭症，ADHD和精神分裂症。这些疾病的公共卫生影响是巨大的。如今，在美国出生的110名儿童（和70名男孩）中有1名被诊断出患有自闭症，并且每年的数字增长了10％至17％。 自闭症具有一系列特征，这些特征表明可能会发生与内分泌相关的改变，包括男性的患病率更高。其他临床线索邀请对自闭症，ADHD和精神分裂症的潜在毒理学，免疫和内分泌破坏性贡献者进行批判性研究。来自神经毒理学27的同行评审论文将迅速发表，在国际上传播，并可以在线访问以容易吸引目标受众。