Cancer Bioinformatics Services

癌症生物信息学服务

基本信息

批准号：
10024339
负责人：
Riyue Bao
金额：
$ 50.45万
依托单位：
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
起止时间：
1997-09-10 至 2025-07-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10024339
关键词：
ATAC-seq Agreement Archives Attention Award Big Data Bioinformatics Biometry Budgets Cancer Center Cancer Center Support Grant Cells ChIP-seq Collaborations Custom Data Data Analyses Data Coordinating Center Data Science Data Sources Development Educational process of instructing Ensure Faculty Foundations Funding Genomics Health Health Science Library High Performance Computing Hour Immunogenetics Individual Infrastructure Institutes Internet Laboratories Malignant Neoplasms Malignant neoplasm of lung Metadata Metagenomics Metastatic breast cancer Methylation Molecular Biology Pathology Play Policies Postdoctoral Fellow Process Reproducibility Research Research Personnel Resource Sharing Role Services Shotguns Skin Cancer Specialized Program of Research Excellence Specimen Students Supercomputing System The Cancer Genome Atlas Time Tissues Universities Work anticancer research biomedical informatics cancer genome cancer genomics computer infrastructure cost cost effective data integration data mining data privacy data sharing exome genome resource genomic data genomic profiles informatics tool machine learning algorithm malignant breast neoplasm member microbiome microbiome analysis precision medicine predictive marker recruit repository single-cell RNA sequencing tool transcriptome sequencing transcriptomics variant detection whole genome

项目摘要

Abstract: Cancer Bioinformatics Services (CBS) The complexity of cancer genome studies—from whole exome, whole genome, methylation, and RNA sequencing to emerging applications such as single cell and immunogenetic sequencing—poses significant challenges in data analysis and computing. The aim of the Cancer Bioinformatics Services (CBS) is to assist Hillman Cancer Center (HCC) investigators with bioinformatics data analysis, provide high performance computing and storage, and create high-value data sources such as the regulatory compliant local repository of TCGA data known as Pittsburgh Genome Resource Repository. CBS, with scientific support from the Department of Biomedical Informatics (DBMI), is co-directed by Drs. Chandran and Bao, and includes two full- time master’s level analysts and partial effort for several additional analysts. CBS supports all genomics studies from individual investigator projects to collaborative and consortia projects with expertise in genomic analysis, metadata annotation, data integration, HPC computing, genomics data privacy and data sharing policies. CBS is a highly collaborative effort involving CBS staff, DBMI faculty, the Pittsburgh Supercomputing Center (an NSF infrastructure), the University of Pittsburgh’s Center for Research Computing, the Institute of Precision Medicine, and the Health Science Library System’s Molecular Biology Service. In addition, CBS works closely with other HCC shared resources including the Biostatistics Facility, Cancer Genomics Facility, and Tissue and Research Pathology Services.

摘要：癌症生物信息学服务（CBS）癌症基因组研究的复杂性——从全外显子组、全基因组、甲基化和 RNA 测序对单细胞和免疫遗传学测序等新兴应用具有重要意义癌症生物信息学服务 (CBS) 的目标是帮助解决数据分析和计算方面的挑战。 Hillman 癌症中心 (HCC) 研究人员通过生物信息学数据分析，提供高性能计算和存储，并创建高价值数据源，例如合规本地存储库被称为匹兹堡基因组资源库的 TCGA 数据，得到了 CBS 的科学支持。生物医学信息学系 (DBMI)，由 Chandran 和 Bao 博士共同领导，包括两名全职教授。时间大师级分析师和其他几位分析师的部分努力支持所有基因组学。从个人研究者项目到具有基因组专业知识的合作和联盟项目的研究分析、元数据注释、数据集成、HPC 计算、基因组数据隐私和数据共享 CBS 是 CBS 工作人员、DBMI 教员和匹兹堡超级计算中心高度协作的成果。中心（NSF 基础设施）、匹兹堡大学研究计算中心、研究所精准医学、健康科学图书馆系统的分子生物学服务此外，哥伦比亚广播公司 (CBS)。与其他 HCC 共享资源密切合作，包括生物统计设施、癌症基因组学设施、组织和研究病理学服务。