Elucidating the measurement of telomeres: Development of a transdisciplinary, high-impact Telomere Research Network

阐明端粒的测量：建立跨学科、高影响力的端粒研究网络

基本信息

批准号：
10024060
负责人：
Stacy Schmidt Drury
金额：
$ 48.66万
依托单位：
TULANE UNIVERSITY OF LOUISIANA
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-09-30 至 2024-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10024060
关键词：
Address Advisory Committees Aging Air Pollution Americas Archives Basic Science Biological Biological Assay Biological Markers Biometry Cardiovascular Diseases Clinical Research Collaborations Data Databases Development Discipline Disease Disease susceptibility Educational workshop Effectiveness Ensure Environmental Exposure Evaluation Explosion Fostering Future Goals Gold Grant Health Individual Infrastructure Laboratories Length Life Life Cycle Stages Link Longevity Measurement Measures Mental Depression Methodology Methods Modeling National Institute of Environmental Health Sciences Network Infrastructure Onset of illness Outcome Pathway interactions Persons Pilot Projects Population Population Study Predictive Value Prevention Procedures Process Protocols documentation Psychosocial Stress Reporting Reproducibility Research Research Personnel Risk Sampling Schizophrenia Scientific Advances and Accomplishments Scientist Sentinel Shapes Stress Telomerase Testing Training Translational Research Validation age related base cohort disorder risk dissemination research early life exposure early life stress expectation healthspan innovation interest meetings mortality next generation novel population based psychosocial recruit research study sample collection telomere virtual web site

项目摘要

PROJECT SUMMARY The proposed Telomere Research Network (TRN) will establish best practices related to telomere length (TL) measurement applicable to population-based studies and will define the extent to which TL can be effectively applied as a sentinel of aging-related disease risk and indicator of environmental and psychosocial stress exposure across the life span. Across scientific fields, the use of telomeres as a marker of exposure and a harbinger of disease risk and accelerated aging is expanding. The explosion of telomere research, while promising, has raised methodological and reporting concerns triggered by inconsistent reproducibility. To address these concerns and advance telomere research, this U24 proposes the following specific AIMS: 1) Create a living network of invested stakeholders to address challenges in determining the extent to which TL is a sentinel of environmental exposures, psychosocial stress, and disease susceptibility; and to ensure the highest rigor and reproducibility in current and future telomere studies. 2) Support and coordinate U01 efforts by ensuring seamless sharing of samples, data, and protocols and fostering interactive discussions focused on best practices for TL measurement. 3) Facilitate the infrastructure for sustained cross-discipline dialogue, dissemination, and research related to TL as a sentinel of cumulative exposure and a predictor of health and aging. To achieve these AIMS, the U24 proposes to recruit a diverse and interactive network of scientists invested in resolving methodologic concerns in TL metrics; engage in formal testing of the extent to which TL, telomerase and other telomere indicators serve as sentinels of age-related disease and cumulative exposures; and define best practices for TL measured in population studies. These AIMS will produce clear methodologic standards, pipelines for increased cross-study analyses and collaboration, and a sustainable platform for continued dialogue related to the measurement of TL and its implications for aging, exposure, and stress research.

项目概要拟议的端粒研究网络（TRN）将建立与端粒长度（TL）相关的最佳实践适用于基于人群的研究的测量，并将定义 TL 作为一种方法可以有效应用的程度与衰老相关的疾病风险的哨兵以及整个生命周期环境和心理社会压力暴露的指标。在整个科学领域，使用端粒作为暴露标记以及疾病风险和加速衰老的预兆正在扩大。端粒研究的爆炸式增长虽然充满希望，但也引起了方法论和报告方面的担忧由不一致的再现性引发。为了解决这些问题并推进端粒研究，本 U24 提出遵循具体目标： 1) 创建一个由投资利益相关者组成的活跃网络，以应对确定投资目标的挑战 TL 在多大程度上是环境暴露、社会心理压力和疾病易感性的哨兵；并确保当前和未来端粒研究中最高的严谨性和可重复性。 2) 支持和协调 U01 的工作确保样品、数据和方案的无缝共享，并促进以最佳实践为重点的互动讨论用于 TL 测量。 3) 促进持续跨学科对话、传播和研究的基础设施 TL 作为累积暴露的哨兵以及健康和衰老的预测因子。为了实现这些目标，U24 提议招募一个多元化、互动的科学家网络，致力于解决 TL 的方法学问题指标；对 TL、端粒酶和其他端粒指标作为哨兵的程度进行正式测试与年龄相关的疾病和累积暴露；并定义人口研究中测量 TL 的最佳实践。这些 AIMS 将制定明确的方法标准、加强交叉研究分析和协作的渠道以及持续对话的可持续平台，涉及 TL 测量及其对老龄化、暴露和健康的影响压力研究。