Elucidating the measurement of telomeres: Development of a transdisciplinary, high-impact Telomere Research Network

阐明端粒的测量：建立跨学科、高影响力的端粒研究网络

• 批准号: 10346650
• 负责人: Stacy Schmidt Drury
• 金额: $ 6.6万
• 依托单位: TULANE UNIVERSITY OF LOUISIANA
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-30 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10346650
• 关键词: Achievement; Address; African American; Age; Alzheimer' s Disease; Alzheimer’s disease biomarker; American; Area; Auditory; Biological Markers; Caring; Cerebrospinal Fluid; Clinical Trials; Cognitive aging; Complex; Coupled; DNA Methylation; Data; Dementia; Detection; Development; Discipline; Disease; Disease susceptibility; Doctor' s Degree; Elderly; Ensure; Environmental Exposure; Epigenetic Process; Etiology; European; Family; Female; Funding; Goals; Impaired cognition; Individual; International; Length; Leukocytes; Life Cycle Stages; Longitudinal prospective study; Measurement; Measures; Minority Enrollment; Minority Groups; Native Americans; Neuropsychology; Neurosciences; Oneida; Outcome; Parents; Performance; Peripheral; Population; Population Study; Psychosocial Stress; Reproducibility; Research; Research Personnel; Risk; Scientist; Sentinel; Societies; Testing; Trail Making Test; Training; Tribes; United States National Institutes of Health; Universities; Verbal Learning; base; career; career development; cell age; cognitive change; cognitive performance; doctoral student; graduate student; high risk; interest; member; middle age; outreach; parent grant; peripheral blood; programs; racial and ethnic; specific biomarkers; telomere

PROJECT SUMMARY This diversity supplement will support the career development for Lauren W. Yowelunh McLester-Davis, a member of the Oneida tribe and the only Native American graduate student at Tulane University. Given the paucity of Native Americans receiving doctoral degrees and NIH funding over the last decade, early targeted support, particularly for exceptionally qualified female Native American researchers in STEMM fields, is critical. This supplement will support one such candidate through a research program directly aligned with her own career goals and key professional interest areas by the Alzheimer's Association International Society to Advance Alzheimer's Research and Treatment – specifically the relation between disease detection, biomarkers and diversity, and ethnoracial factors related to Alzheimer's disease and related disorders (ADRD). The proposed supplement is aligned with the parent U24 (U24AG066528), that established the Telomere Research Network (TRN) to determine best practices for measurement of telomere length (TL) applicable to population-based studies and determine the ability of TL to serve a sentinel of the environmental exposome, psychosocial stress, and disease susceptibility across the life course. The proposed supplement will expand the aims of the parent grant with the following supplemental AIMS: Aim 1: To determine the relationship between TL and neuropsychological performance in African American and Native American middle-aged and older adults. It is hypothesized that the Rey Auditory Verbal Learning Test (RAVLT) and the Trail Making Test (TMT), which capture subtle cognitive changes associated with ADRD, will be significantly associated with peripheral blood TL within African and Native Americans. Aim 2a: To assess the correlation between TL in CSF and peripheral blood. It is hypothesized that TL measured in peripheral blood with be significantly correlated with TL measured from TL measured from white blood cells (WBCs) obtained from cerebrospinal fluid (CSF). Aim 2b: To assess the correlation of TL with DNA methylation- based age (DNAm age) from cells in CSF in middle-aged and older adults. It is hypothesized that TL will be associated with DNAm age and that CSF TL will demonstrate a stronger correlation with DNAm age in CSF WBCs than TL measured in peripheral WBC. Together the achievement of these Aims is expected to contribute to an enhanced understanding of relation between TL and with neuropsychological outcomes in minoritized populations and specific biomarkers of ADRD.

项目概要 这种多样性补充将支持 Lauren W. Yowelunh 的职业发展 麦克莱斯特-戴维斯，奥奈达部落成员，也是唯一的美洲原住民研究生 鉴于获得博士学位和 NIH 的美洲原住民很少。 过去十年的资助，早期有针对性的支持，特别是针对特别合格的 STEMM 领域的美国原住民女性研究人员至关重要，本补充品将提供支持。 其中一位候选人通过一项与她自己的职业目标直接相关的研究项目，并且 阿尔茨海默病协会国际进步协会的主要专业兴趣领域 阿尔茨海默氏症的研究和治疗——特别是疾病检测之间的关系， 与阿尔茨海默氏病及相关疾病相关的生物标志物和多样性以及民族因素 拟议的补充剂与母体 U24 (U24AG066528) 一致， 建立了端粒研究网络 (TRN)，以确定端粒研究的最佳实践 适用于基于人群的研究的端粒长度 (TL) 测量并确定 TL 充当环境暴露、社会心理压力和哨兵哨兵的能力 拟议的补充将扩大整个生命过程中的疾病易感性。 家长补助金具有以下补充目标： 目标 1：确定关系 非裔美国人和原住民的 TL 与神经心理学表现之间的关系 美国中老年人重新认识雷伊听觉言语。 学习测试 (RAVLT) 和轨迹制作测试 (TMT)，捕捉微妙的认知 与ADRD相关的变化，将与外周血TL显着相关 目标 2a：评估 CSF 和 TL 之间的相关性。 外周血中测定的TL与显着上升。 与从获得的白细胞 (WBC) 测量的 TL 测量的 TL 相关 目标 2b：评估 TL 与 DNA 甲基化的相关性。 根据中老年人脑脊液细胞的年龄（DNAm 年龄）。 证实 TL 将与 DNAm 年龄相关，并且 CSF TL 将表现出 与 CSF WBC 中 DNAm 年龄的相关性强于外周 WBC 中测量的 TL。 这些目标的实现预计将有助于增强 了解 TL 与少数民族神经心理学结果之间的关系 ADRD 的人群和特定生物标志物。