Pilot Innovation Core

试点创新核心

• 批准号: 10023723
• 负责人: STEVEN M KOGAN
• 金额: $ 11.86万
• 依托单位: UNIVERSITY OF GEORGIA
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-01 至 2025-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10023723
• 关键词: Addictive Behavior; Address; Adolescence; Adolescent; Affect; African American; Age; Alcohol or Other Drugs use; Applications Grants; Area; Attenuated; Award; Behavioral; Biological Process; Brain; Cancer Grant Supplements (P30); Centers of Research Excellence; Childhood; Chronic stress; Communities; Data; Data Analyses; Data Set; Development; Diet Habits; Disease; Drug usage; Eating; Etiology; Exposure to; Family; Feedback; Fostering; Foundations; Functional Magnetic Resonance Imaging; Funding; Funding Mechanisms; Future; Generations; Goals; Grant; Health; Immune; Immunology; Individual; Inflammation; Inflammation Mediators; Investigation; Mediator of activation protein; Mentors; Mentorship; Methodology; Minority; Modeling; Monitor; Neurobiology; Neuroimmune; Neurosciences; Observational Study; Peer Review; Pilot Projects; Plant Roots; Population; Poverty; Prevention; Prevention program; Prevention trial; Preventive; Process; Publications; Randomized; Recording of previous events; Research; Research Personnel; Research Training; Resources; Risk; Role; Sample Size; Science; Scientific Advances and Accomplishments; Scientist; Seeds; System; Training; Underrepresented Groups; Universities; Work; age group; cardiometabolism; career; career development; cohort; contextual factors; design; drug abuse prevention; drug development; experience; faculty mentor; innovation; insight; interdisciplinary collaboration; network models; next generation; novel; novel strategies; pedagogy; programs; psychosocial; racial discrimination; randomized trial; ranpirnase; recruit; relating to nervous system; research study; resilience; secondary analysis; social; substance use prevention; success; training project; transmission process; working group; young adult

PROJECT SUMMARY: Pilot Core The Pilot Core of the proposed P50 supports the vitality of the Center by facilitating investigator development and promoting new research insights and priorities for the Center’s research studies. This program will provide a funding mechanism for pilot project applications from early career investigators (ECIs) and from established investigators seeking to extend their research into assessment of neural and inflammatory mediators of drug use and cardiometabolic health. Investigators can access seed grant funding and Center resources to (a) assess the feasibility of exploring a new research question, (b) apply a new approach, or (c) use existing methodology to explore a novel way to advance a new area of scientific exploration. The seed grant program also will provide resources to support secondary data analysis of CTAPS datasets from concluded and ongoing projects. These datasets were collected through both longitudinal, observational research and randomized prevention trials. Our datasets will permit replication of findings, comparison of models for different age groups (e.g., adolescents versus young adults), and aggregation of variables across data sets (harmonization) to maximize sample size or the age span to be evaluated. In addition to the investigator career development that occurs via seed grant funding, we propose to implement a targeted mentoring program for ECIs. Although not limited to minority or African American ECIs, an expressed goal of this program is to recruit early-career scientists from underrepresented backgrounds at UGA and our P50 partner, Northwestern University (NWU). This program is informed by CTAPS investigators’ experience with mentoring in the P30, a history of systematic mentoring for junior faculty, mentoring via diversity supplements, and implementing an Institutional Research Training Grant. To initiate the Year 1 (Y1) pilot project and mentoring system, we designed a unique pilot that will serve as a collaborative training experience for the Y1 mentoring cohort and advance the scientific aims of the Center. This experience centers around a secondary data analysis of fMRI, inflammation, and psychosocial data collected during the past CTAPS P30 grant period. The training cohort will work with this unique, rich data set under the guidance of Dr. Brody, the Center Director, with methodological and substantive support from P50 scientists and statisticians. The aims of our Pilot Core are to: (1) administer a seed grant program designed to support pilot projects that address African Americans’ drug use and cardiometabolic vulnerabilities; (2) provide targeted mentoring to early-career investigators, particularly those from underrepresented groups; and (3) implement a unique Year 1 pilot project/training experience: “Racial discrimination, protective processes, and drug use among African Americans: The role of NIN mechanisms.”

项目摘要：试点核心 拟议 P50 的试点核心通过促进研究者发展来支持中心的活力 该计划将为该中心的研究提供新的研究见解和优先事项。 早期职业研究者 (ECI) 和已建立的试点项目申请资助机制 研究人员寻求将他们的研究扩展到药物的神经和炎症介质的评估 研究人员可以获得种子拨款资金和中心资源以进行 (a) 评估探索新研究问题的可行性，（b）应用新方法，或（c）使用现有的 探索一种新方法来推进新领域的科学探索种子资助计划。 还将提供资源来支持对 CTAPS 数据集进行二次数据分析 这些数据集是通过纵向、观察性研究和 我们的数据集将允许复制研究结果，比较不同的模型。 年龄组（例如青少年与年轻人）以及跨数据集的变量聚合 （协调）除了研究者的职业之外，还可以最大化样本量或要评估的年龄跨度。 通过种子拨款资金实现的发展，我们建议实施有针对性的指导计划 ECI 虽然不限于少数族裔或非裔美国人 ECI，但该计划的一个明确目标是招募人员。 来自佐治亚大学和我们的 P50 合作伙伴西北大学代表性不足背景的早期职业科学家 大学 (NWU)。该计划借鉴了 CTAPS 调查人员在 P30 中的指导经验。 对初级教师进行系统指导、通过多样性补充进行指导以及实施 机构研究培训补助金 为了启动第一年 (Y1) 试点项目和指导系统，我们 设计了一个独特的试点项目，作为一年级指导群体的协作培训体验， 推进该中心的科学目标，这一经验围绕功能磁共振成像的二次数据分析， 培训队列将在过去的 CTAPS P30 资助期间收集炎症和心理社会数据。 在中心主任布罗迪博士的指导下，通过方法论来处理这个独特、丰富的数据集 以及 P50 科学家和统计学家的实质性支持 我们试点核心的目标是：(1) 管理。 旨在支持解决非裔美国人吸毒问题的试点项目的种子赠款计划 (2) 为早期职业研究者提供有针对性的指导，特别是那些 来自代表性不足的群体；(3) 实施独特的第一年试点项目/培训经验：“种族 非裔美国人中的歧视、保护过程和吸毒：NIN 机制的作用。”