High Performance Detectors for SPECT

用于 SPECT 的高性能探测器

• 批准号: 8072309
• 负责人: MICHAEL R. SQUILLANTE
• 金额: $ 58.15万
• 依托单位: RADIATION MONITORING DEVICES, INC.
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-25 至 2012-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8072309
• 关键词: Address; Animal Experimentation; Anisotropy; Area; Arizona; Biological Models; Brain; Bromides; Caliber; Cardiac; Cerium; Cherry - dietary; Clinical; Collaborations; Collection; Collimator; Colorado; Coronary Arteriosclerosis; County; Coupled; Coupling; DCNU; Data Display; Development; Diagnosis; Discipline of Nuclear Medicine; Electrons; Elements; Environment; Evaluation; Family; Floods; Gamma Rays; Goals; Growth; Healthcare; Heart; Human; Image; Imaging Phantoms; Investigation; Ions; Isotopes; Kidney; Laboratories; Lanthanum; Length; Light; Liver; Lung; Malignant Neoplasms; Measures; Medical Imaging; Methods; Minerals; Myocardial perfusion; Names; Optics; Organ; Output; Patients; Performance; Phase; Photons; Physics; Physiology; Play; Positron-Emission Tomography; Process; Property; Prostate; Radial; Radioisotopes; Reading; Research; Resolution; Role; Saints; Semiconductors; Silicon; Site; Skeletal system; Source; Spectrum Analysis; Staging; Structure; Study of magnetics; System; Technology; Temperature; Testing; Thick; Time; Tissues; Travel; Tube; Universities; abstracting; base; commercialization; cost; design; detector; imaging detector; imaging modality; improved; in vivo; instrumentation; luminescence; melting; outcome forecast; photomultiplier; prototype; public health relevance; response; single photon emission computed tomography; statistics; thallium-doped sodium iodide; tool; two-dimensional

DESCRIPTION (provided by applicant): High Performance Detectors for SPECT P.I.: Dr. Michael R. Squillante Abstract Single photon emission computed tomography (SPECT) is a powerful, noninvasive medical imaging modality that mathematically reconstructs the three dimensional distribution of a radionuclide throughout the body of a human patient or a research animal. Typically, the collected data are displayed and evaluated as a set of two-dimensional images through the organ or diseased area under investigation. SPECT allows quantitative study of the function in the investigated region and therefore is an extremely useful tool for understanding organ and tissue physiology including that in the heart. SPECT is very commonly used in identifying as well as localizing coronary artery disease and as many as 90% of all myocardial perfusion studies are now performed using SPECT. Thus, SPECT is playing a critical role in cardiac imaging, providing both diagnosis as well as prognosis. However, there is urgent need for improvement in the instrumentation that is currently used for this imaging modality and expand its capabilities in order to exploit its full potential. At present, the performance of SPECT systems often is limited by the detectors used in these systems. Modern SPECT systems consist of scintillation crystals coupled to photomultiplier tubes as detectors. Important requirements for scintillators used in SPECT applications include high light output and high energy resolution, reasonably fast response and high gamma ray stopping efficiency. Ideally, the scintillator should also be inexpensive, rugged and easy to manufacture. Currently, NaI(Tl) is the detector of choice in SPECT systems and it is relatively inexpensive and its light output is fairly large. However, the poor energy resolution of NaI(Tl) often limits SPECT performance. The energy resolution of NaI:Tl is limited by its relatively poor proportionality. If scintillators with higher energy resolution at typical SPECT energies (~140 keV) were available, the essential process of scatter rejection would improve. The goal of the proposed effort is to investigate new high resolution detectors for SPECT studies. Enhanced scatter rejection can be expected from the new detectors, which are also expected to be relatively easy to produce. The Phase I project will be aimed at demonstrating the feasibility of the proposed concept, while the Phase II project will be aimed at optimization of the new detectors, implementation of the prototype modules and detailed performance evaluation. PUBLIC HEALTH RELEVANCE: High Performance Detectors for SPECT P.I.: Dr. Michael R. Squillante Project Narrative - The proposed research will investigate a promising detector technology which should have a major impact in health care, in particular, in the development of detectors for in-vivo imaging. Other areas to which this research could be of benefit are: physics research, materials studies, homeland defense, and non-destructive testing.

描述（由申请人提供）：SPECT P.I。的高性能检测器：Michael R. Squillante博士抽象单光子发射计算机断层扫描（SPECT）是一种功能强大的无创医学成像模态，数学从数学上重建整个人类患者或研究动物或研究动物或研究动物的整个身体的三维分布。通常，通过正在调查的器官或患病区域显示收集的数据作为一组二维图像显示和评估。 SPECT允许对研究区域的功能进行定量研究，因此是理解器官和组织生理的极为有用的工具。 SPECT非常常用于识别和定位冠状动脉疾病，现在所有心肌灌注研究中多达90％是使用SPECT进行的。因此，SPECT在心脏成像中起着至关重要的作用，提供诊断和预后。但是，迫切需要改进该仪器，该仪器目前用于这种成像方式并扩展其功能以利用其全部潜力。目前，SPECT系统的性能通常受这些系统中使用的检测器的限制。现代的Spect系统由闪烁晶体组成，该晶体偶联到光电倍增管作为检测器。光谱应用中使用的闪光灯的重要要求包括高光输出和高能量分辨率，合理的快速响应以及高γ射线停止效率。理想情况下，闪烁体还应便宜，坚固且易于制造。当前，NAI（TL）是SPECT系统中选择的检测器，它相对便宜，其光输出相当大。但是，NAI（TL）的能量分辨率不足通常会限制SPECT性能。 NAI：TL的能量分辨率受其相对较差的比例限制。如果可以使用典型的幽灵能量（〜140 KEV）的能量分辨率较高的闪烁体，则散射拒绝的基本过程将改善。拟议的努力的目的是研究SPECT研究的新高分辨率探测器。新探测器可以预期增强的散射拒绝，这些探测器也有望相对容易产生。第一阶段项目将旨在证明拟议概念的可行性，而第二阶段项目将旨在优化新检测器，实现原型模块和详细的性能评估。公共卫生相关性：SPECT P.I。的高性能检测器：Michael R. Squillante项目叙事 - 拟议的研究将调查有前途的探测器技术，该技术应该对医疗保健产生重大影响，特别是在开发Vivo Intiming Imaging的探测器方面。这项研究可能有益的其他领域是：物理学研究，材料研究，国土防御和非破坏性测试。