Lipid peroxidation-induced chemical modifications of insulin signaling proteins

脂质过氧化诱导的胰岛素信号蛋白化学修饰

• 批准号: 8119876
• 负责人: Krisztian Stadler
• 金额: $ 24.9万
• 依托单位: LSU PENNINGTON BIOMEDICAL RESEARCH CTR
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-15 至 2013-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8119876
• 关键词: 4 hydroxynonenal; Acute; Aftercare; Aldehyde Reductase; Aldehydes; Animal Model; Animals; Atherosclerosis; Attenuated; Cardiovascular system; Cause of Death; Cells; Chemicals; Chronic; Complications of Diabetes Mellitus; Data; Detection; Development; Diabetes Mellitus; Diabetic Nephropathy; Diet; Disease; Electron Spin Resonance Spectroscopy; Enzymes; Fatty acid glycerol esters; Free Radical Formation; Free Radicals; Glucose; Health; Heart failure; Human; Hydroxyl Radical; Hyperglycemia; Image; Impairment; In Situ; Incidence; Inflammation; Inflammatory; Injection of therapeutic agent; Insulin; Insulin Receptor; Insulin Resistance; Insulin Signaling Pathway; Insulin-Dependent Diabetes Mellitus; Kidney; Laboratories; Lead; Lipid Peroxidation; Lipid Peroxides; Lipids; Liver; Mediating; Metabolic Diseases; Methodology; Methods; Mitochondria; Modeling; Modification; Mus; NADP; Neuropathy; Nitrogen; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Oxidants; Oxidative Stress; Oxygen; Participant; Pathogenesis; Pathway interactions; Patients; Pattern; Peroxonitrite; Phosphorylation; Prevention; Process; Production; Proteins; Rattus; Receptor Signaling; Retinal Diseases; Rodent; Role; Scheme; Signal Pathway; Signal Transduction; Signaling Protein; Site; Skeletal Muscle; Source; Spin Trapping; Staging; Streptozocin; Stress; Techniques; Testing; Therapeutic Agents; Time; Tissues; Work; World Health Organization; Xanthines; Zucker Rats; base; clinically relevant; diabetic; diabetic patient; diabetic rat; glycation; human NOS2A protein; improved; in vivo; inhibitor/antagonist; insight; insulin receptor substrate 1 protein; insulin sensitivity; insulin signaling; insulin tolerance; macrophage; nitration; novel; oral glucose tolerance; overexpression; oxidation; polyol; public health relevance; research study; restoration; rosiglitazone; type I and type II diabetes; type I diabetic