Enzymatic transdermal alcohol biosensor

酶促透皮酒精生物传感器

• 批准号: 10020888
• 负责人: Bob Michael Lansdorp
• 金额: $ 103.31万
• 依托单位: MILO SENSORS, INC.
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-20 至 2023-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10020888
• 关键词: Accountability; Address; Affect; Alcohol consumption; Alcoholic Intoxication; Alcohols; Awareness; Beer; Biosensor; Blood alcohol level measurement; Businesses; Cellular Phone; Centers for Disease Control and Prevention (U.S.); Clinical; Communities; Concentration measurement; Conscious; Controlled Environment; Databases; Decision Making; Development; Device or Instrument Development; Devices; Diffuse; Disease; Disease Management; Dose; Economic Burden; Engineering; Environment; Enzymes; Evaluation; Generations; Goals; Health; Heavy Drinking; Human; In Situ; Incidence; Injections; Injury; Intoxication; Laboratories; Laboratory Study; Lead; Legal patent; Life; Measurement; Measures; Molds; Monitor; Names; Outcome; Outcomes Research; Performance; Persons; Phase; Police; Prevalence; Production; Proxy; Recording of previous events; Reporting; Reproducibility; Research; Research Personnel; Research Project Grants; Running; Skin; Small Business Innovation Research Grant; Societies; Techniques; Technology; Testing; United States; Validation; Wireless Technology; alcohol misuse; alcohol monitoring; alcohol research; base; behavioral study; burden of illness; cost; design; drinking; drinking behavior; field study; health economics; improved; incentive program; instrument; outreach program; preventable death; sensor; sensor technology; societal costs; tool; transmission process; treatment program; wearable device

Alcohol consumption has widespread prevalence with global impact on societies, economies, and health. Overconsumption and misuse of alcohol has led to significant burdens, including nearly 88,000 fatalities in 2006 (CDC, 2013), contribution to more than 200 diseases and injury-related health conditions totaling 5.1% of the burden of disease and injury worldwide (Sacks, 2014), and costs greater than $249 billion annually in the USA alone (Sacks, 2014). This project aims to impact the aforementioned societal, health, and economic burdens by increasing awareness of alcohol consumption, intoxication, and misuse. The proposed wearable technology leverages Milo Sensors’ patented transdermal analyte sensing technology (US Patent 9,855,000) to develop a highly sensitive, non-invasive enzymatic transdermal alcohol sensor for continuous measurement of Blood Alcohol Concentration (BAC). Supported by successful completion of SBIR Phase I Research Aims, expected outcomes from this research project include: 1) development of device manufacturing techniques for the reliable production of low cost, high-sensitivity enzymatic biosensors, 2) clinical validation of the transdermal alcohol quantification through comparisons of the proposed technology to commercially available transdermal alcohol sensors, as well as to police-grade breath alcohol instruments as a proxy for BAC, and 3) research validation of biosensor performance and low-power wireless transmission capabilities in intended use settings. Milo Sensors’ technology will enable continuous monitoring of alcohol in applications where measurement is critical to understanding decision-making, drinking behavior, and health. Validation gathered from this study could lead towards the development of a wearable alcohol platform capable of continuous alcohol monitoring for improved decision-making and accountability, leading to increased awareness, disease management and health outcomes.

酒精消费广泛流行，对社会、经济、 过度消费和滥用酒精已导致重大负担，包括 2006 年有近 88,000 人死亡（CDC，2013），导致 200 多种疾病和 与伤害相关的健康状况占全球疾病和伤害负担的 5.1% （Sacks，2014），仅在美国每年的成本就超过 2490 亿美元（Sacks，2014）。 该项目旨在通过以下方式影响社会、健康和经济负担 提高人们对饮酒、中毒和滥用的认识。 技术利用 Milo Sensors 的专利透皮分析物传感技术（美国 专利 9,855,000）开发一种高度敏感、非侵入性酶促透皮酒精 用于连续测量血液酒精浓度 (BAC) 的传感器。 成功完成 SBIR 第一阶段研究目标，本研究的预期成果 项目包括：1）开发可靠生产的器件制造技术 低成本、高灵敏度的酶生物传感器，2）透皮的临床验证 通过将拟议技术与商业技术进行比较来定量酒精 可用的透皮酒精传感器以及警用级呼吸酒精仪器 BAC 的代理，以及 3) 生物传感器性能和低功耗无线的研究验证 Milo Sensors 的技术将实现在预期使用环境中的传输能力。 在测量对于理解至关重要的应用中连续监测酒精 从这项研究中收集的验证可能会导致决策、饮酒行为和健康。 开发可连续饮酒的可穿戴酒精平台 监测以改进决策和问责制，从而提高认识， 疾病管理和健康结果。