Core 2: Biostatistics and Bioinformatics Core

核心2：生物统计学和生物信息学核心

• 批准号: 10000843
• 负责人: David Elashoff
• 金额: $ 12.5万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-15 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10000843
• 关键词: Adopted; Applications Grants; Area; Basic Science; Bioinformatics; Biometry; Clinical Investigator; Clinical Research; Clinical Trials; Cloud Computing; Computer software; Consult; Consultations; Custom; Data; Data Analytics; Development; Education; Ensure; Evaluation; Experimental Designs; Flow Cytometry; Gene Chips; Genomics; Goals; Individual; Leadership; Malignant neoplasm of prostate; Manuscripts; Methodology; Pathway Analysis; Preparation; Prostate; Proteomics; Publications; Quality Control; RNA; Reporting; Reproducibility; Research; Research Design; Research Personnel; Research Project Grants; Resources; Services; Statistical Data Interpretation; T-Cell Receptor; Technology; Tissue Microarray; Translational Research; anticancer research; base; design; exome; gang; high dimensionality; member; power analysis; preclinical study; programs; tool; translational study

PROJECT SUMMARY/ABSTRACT The Biostatistics and Bioinformatics Core (BBC), will facilitate translational research in prostate cancer, by providing UCLA investigators and their colleagues with state of the art biostatistical, bioinformatics and clinical trials support. The BBC provides a centralized network of biostatistics and bioinformatics support for prostate cancer researchers at UCLA and their collaborators. The overall goal of the Core is to provide statistical and bioinformatic support to basic and clinical investigators in the SPORE. The statistical consulting will be led by Dr. David Elashoff and supported by Dr. Gang Li and will include consultation on power analyses and experimental design for planning of preclinical and clinical studies. The core will collaborate on the development of statistical analysis plans and assist with carrying out those plans. The Bioinformatics component will be led by Dr. Thomas Graeber and supported by Dr. Paul Boutros. The Core provides analytical services for all genomics research, including RNA/whole exome/T-cell receptor sequencing and proteomic analysis within the SPORE. For these data types the core will assist with data preprocessing, pipeline development and cloud computing, quality control evaluation, and both standard and custom integrative and network analysis. The core will assist with the reporting of research findings in manuscripts. Finally, the Biostatistics and Bioinformatics Core provides yearly educational seminars and courses to all SPORE investigators.

项目概要/摘要 生物统计学和生物信息学核心（BBC）将通过以下方式促进前列腺癌的转化研究 为加州大学洛杉矶分校的研究人员及其同事提供最先进的生物统计学、生物信息学和临床知识 试验支持。 BBC 为前列腺提供生物统计学和生物信息学支持的集中网络 加州大学洛杉矶分校的癌症研究人员及其合作者。核心的总体目标是提供统计和 为 SPORE 的基础和临床研究人员提供生物信息支持。统计咨询将由 David Elashoff 博士和李刚博士的支持，将包括功率分析和 用于规划临床前和临床研究的实验设计。核心将合作开发 统计分析计划并协助执行这些计划。生物信息学部分将由 由 Thomas Graeber 博士负责，并得到 Paul Boutros 博士的支持。核心为所有人提供分析服务 基因组学研究，包括 RNA/全外显子组/T 细胞受体测序和蛋白质组学分析 孢子。对于这些数据类型，核心将协助数据预处理、管道开发和云 计算、质量控制评估以及标准和定制的综合和网络分析。核心 将协助报告手稿中的研究结果。最后，生物统计学和生物信息学核心 每年为所有 SPORE 调查员提供教育研讨会和课程。