COBRE for Skeletal Health & Repair

COBRE 促进骨骼健康

基本信息

批准号：
10019391
负责人：
QIAN CHEN
金额：
$ 114.6万
依托单位：
RHODE ISLAND HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-09-01 至 2022-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10019391
关键词：
American Animals Basic Science Benchmarking Biomechanics Biomedical Engineering Caliber Cartilage Cartilage Diseases Cells Center for Translational Science Activities Centers of Research Excellence Collaborations Core Facility Degenerative polyarthritis Development Diagnostic Discipline Engineering Environment Equipment Faculty Funding Future Generations Goals Grant Health Hospitals Image Infrastructure International Joints Laboratories Leadership Mentors Molecular Molecular Biology Motion Musculoskeletal Musculoskeletal Diseases Nature Organ Peer Review Performance Phase Pilot Projects Prevention Prevention strategy Principal Investigator Publishing Research Research Infrastructure Research Peer Review Research Personnel Research Project Grants Resources Rhode Island Science Scientist Services Side Testing Therapeutic Tissues Training Training Programs Translational Research United States National Institutes of Health Universities Vision arthropathies bench to bedside disability interdisciplinary approach laboratory facility multidisciplinary nanomaterials nanomedicine novel programs recruit repaired skeletal success translational approach treatment strategy

项目摘要

Overall 7. Project Summary/Abstract The long-term goal of the Center of Biomedical Research Excellence (COBRE) for Skeletal Health and Repair is to develop a multi-disciplinary translational research center focusing on discovering mechanisms of cartilage joint diseases and developing prevention and treatment strategies. Since the start of the COBRE eight years ago, seven full project investigators have received R01 or R01-equivalent federal grants and “graduated” from the COBRE training program, and published more than 240 peer-reviewed articles including landmark discoveries in Nature, Molecular Cell, and PNAS. All twenty target junior investigators have received exramural funding as Principal Investigator, and new state-of-the-art laboratories and core facilities have been built in bioengineering, imaging, molecular biology and nanomedicine. The main objective of the Phase III COBRE is to strengthen and transition the COBRE research infrastructure into a competitive, independent, and self- sustaining academic center of excellence-Brown Center of Musculoskeletal and Motion Sciences (BCMMS) in five years. To achieve this main objective, four specific aims are proposed as follows. Aim 1, Administrative Core provides strong leadership in translational research, evaluates the performance of technical Core Resources and Facilities, guides mentoring efforts in the Pilot Projects Program, and implements the COBRE transitioning plan; Aim 2, Bioengineering Core enhances an interactive research environment and provides the unique resources of biomechanical testing at the cell, tissue, and organ levels; Aim 3, Imaging, Molecular Biology, and Nanomedicine Core enhances translational research from bench to bedside, provides critical expertise and equipment in small animal live imaging analysis, and facilitates development of novel nanomaterial delivery vehicles for diagnostics and therapeutics; and Aim 4, Pilot Projects Program mentors a new generation of researchers in multiple disciplines of musculoskeletal research including clinicians, biologists, and engineers, facilitates research collaborations, and sustains the strong research environment developed in the first two phases of COBRE. Our vision is, by sustaining and transitioning the established high- caliber research infrastructure, we will enable clinicians working side-by-side with basic research scientists, junior investigators with senior investigators, and biologists with bioengineers for a long term into the future.

全面的 7. 项目总结/摘要骨骼健康与修复卓越生物医学研究中心 (COBRE) 的长期目标旨在建立一个多学科转化研究中心，专注于发现软骨机制自 COBRE 启动八年来，共同制定疾病及其预防和治疗策略。此前，七名完整的项目调查员已获得 R01 或 R01 同等的联邦拨款，并从 COBRE 培训计划，并发表了 240 多篇同行评审文章，其中包括具有里程碑意义的文章《自然》、《分子细胞》和《美国国家科学院院刊》上的所有 20 名目标初级研究人员都接受过校外研究。作为首席研究员的资助，并建立了新的最先进的实验室和核心设施生物工程、成像、分子生物学和纳米医学第三阶段 COBRE 的主要目标是。加强 COBRE 研究基础设施并将其转变为有竞争力的、独立的、自主的维持卓越学术中心 - 布朗肌肉骨骼和运动科学中心 (BCMMS) 为实现这一主要目标，提出了以下四个具体目标：目标 1，行政。 Core 在转化研究方面提供强大的领导力，评估技术 Core 的性能资源和设施，指导试点项目计划中的指导工作，并实施 COBRE 过渡计划；目标 2，生物工程核心增强互动研究环境并提供细胞、组织和器官水平的生物力学测试的独特资源；目标 3、成像、分子；生物学和纳米医学核心增强了从实验室到临床的转化研究，提供了关键的小动物活体成像分析方面的专业知识和设备，并促进新颖的开发用于诊断和治疗的纳米材料输送工具；目标 4，试点项目计划指导肌肉骨骼研究多个学科的新一代研究人员，包括信徒，生物学家和工程师促进研究合作并维持强大的研究环境我们的愿景是通过维持和转变既定的高水平。口径研究基础设施，我们将使劳动力与基础研究科学家并肩工作，初级研究人员与高级研究人员，生物学家与生物工程师，从长远来看。