Advanced Instrumental Development Core: Medical College of Wisconsin

高级仪器开发核心：威斯康星医学院

• 批准号: 8013162
• 负责人: JAMES S HYDE
• 金额: $ 45.45万
• 依托单位: DARTMOUTH COLLEGE
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-15 至 2015-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8013162
• 关键词: Advanced Development; Agreement; Anxiety; Area; Cancer Center Support Grant; Characteristics; Collaborations; Development; Frequencies; Goals; Heart; Individual; Ionizing radiation; Leadership; Measurement; Medical; Modeling; Nail plate; Population; Resources; Role; Site; Techniques; Technology; Time; Tooth structure; Universities; Wisconsin; Work; design; dosimetry; improved; in vivo; instrument; instrumentation; medical schools; microwave electromagnetic radiation; prototype; response

This core provides input from what is generally agreed to be the leading EPR instrumental development site in the world, the National Biomedical EPR Center at the Medical College of Wisconsin (MCW). The role of this core will be to provide leadership in the development of specific aspects of the technology needed to accomplish the goals ofthe CMCR. These developments will be carried out in collaboration with the projects and with the instrumental Core at Dartmouth, to facilitate the development of the best possible o prototype instruments for EPR dosimetry. The contributions ofthe core at MCW are described in four specific aims. Specific Aim 1 (50% of effort) is the Development of resonators for measurements at X-Band in vivo for nails and teeth; this will be the most extensive project and will focus on exploiting the breakthrough achieved in initial collaborative studies where for the first time, resonators that operate at the very sensitive X-Band frequency were successfully used to make measurements in vivo. This development is at the heart of project 3. During the course of the grant this core will attempt to make analogous resonators that can be used for in vivo tooth dosimetry, which could dramatically improve the already impressive sensitivity of this approach (Project 1). Specific Aim 2 (25% of effort) - Development of instrumentation to support measurements at X-Band, will especially focus on development of specifically designed microwave bridges that will facilitate both Projects 2 &3. These developments will be carried out in collaboration with a longstanding collaborative partner of both Dr. Hyde and Dr. Swartz, Dr. Froncisz of the Jagiellonian University in Krakow (Dr. Froncisz's support will come via a purchase agreement. Specific Aim 3 (20% of effort) - Improvements in resonators and bridges for measurements at L-Band. This core will similarly work with Dartmouth and Krakow in the development of improved L-Band bridges, in support of Project 1. It also will facilitate resonator development in project 1 by use ofthe very sophisticated modeling techniques that are highly developed at MCW, which enable different configurations of resonators to e=be rigorously evaluated so that construction can be focused on designs that are likely to be successful Specific Aim 4 -(5 % of effort) support of multifrequency studies will available an exceptional set of EPR spectrometers that can be of value to all three projects in helping to elucidate the characteristics of potentially overlapping components of EPR spectra.

该核心提供了来自被普遍认为是世界领先的 EPR 仪器开发站点——威斯康星医学院国家生物医学 EPR 中心 (MCW) 的输入。该核心的作用是领导开发实现 CMCR 目标所需的技术的特定方面。这些开发将与达特茅斯的项目和仪器核心合作进行，以促进 EPR 剂量测定的最佳原型仪器的开发。 MCW 核心的贡献分为四个具体目标。具体目标 1（50% 的努力）是开发用于 X 波段体内指甲和牙齿测量的谐振器；这将是最广泛的项目，重点是利用在最初的合作研究中取得的突破，其中首次成功地使用在非常敏感的 X 波段频率下工作的谐振器进行体内测量。这种发展是核心 项目 3. 在资助过程中，该核心将尝试制作类似的谐振器 用于体内牙齿剂量测定，这可以显着提高这种已经令人印象深刻的灵敏度 方法（项目 1）。具体目标 2（25% 的工作量）- 开发仪器以支持 X 波段测量将特别关注专门设计的微波电桥的开发 这将促进项目 2 和 3。这些开发将与长期合作进行 Hyde 博士和 Swartz 博士的合作伙伴，雅盖隆大学的 Froncisz 博士 在克拉科夫（Froncisz 博士的支持将通过购买协议提供。具体目标 3（20% 的努力）- 用于 L 波段测量的谐振器和电桥的改进。该核心将与达特茅斯和克拉科夫类似地合作开发改进的 L 波段电桥，以支持项目 1。它还将通过使用 MCW 高度开发的非常复杂的建模技术来促进项目 1 中谐振器的开发，这使得不同的谐振器配置 e= 进行严格评估，以便施工可以集中于可能成功的设计 具体目标 4 -（5% 的努力）对多频率研究的支持将提供一组特殊的 EPR光谱仪对所有三个项目都有价值，有助于阐明 EPR 光谱中潜在重叠成分的特征。