GDP AND GTP BINDING TO RAB 5

GDP 和 GTP 与 RAB 5 结合

• 批准号: 8168730
• 负责人: PHILIP D STAHL
• 金额: $ 0.35万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-03-10 至 2010-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8168730
• 关键词: Animals; Binding; Computer Retrieval of Information on Scientific Projects Database; Funding; Grant; Guanosine Triphosphate; Institution; Knockout Mice; Protein Isoforms; Proteins; Research; Research Personnel; Resources; Sequence Homology; Signaling Protein; Source; Structure; United States National Institutes of Health

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Rab5 is a signaling protein that exists in three isoforms. All forms (Rab5 A, Rab5B, Rab5 C) have significant sequence homology and similar structures. It was once believed that these proteins were redundant, however recent studies with knock out mice have demonstrated that each isoform is required healthy animals. A conformational change occurs upon binding GDP or GTP.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 Rab5 是一种信号蛋白，存在三种亚型。 所有形式（Rab5 A， Rab5B、Rab5C)具有显着的序列同源性和相似的结构。 它 曾经被认为这些蛋白质是多余的，然而最近的研究 敲除小鼠已证明每种异构体都是健康所必需的 动物。结合 GDP 或 GTP 时会发生构象变化。