SELENIUM RICH LENTILS: A WHOLE FOOD SOLUTION FOR IMPROVED HUMAN HEALTH?

富硒扁豆：改善人类健康的完整食品解决方案？

• 批准号: 8170060
• 负责人: INGRID J PICKERING
• 金额: $ 0.95万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8170060
• 关键词: Affect; American; Area; Arsenic; Bangladesh; Canada; Chemicals; Clinical Trials; Computer Retrieval of Information on Scientific Projects Database; Country; Diet; Drug Metabolic Detoxication; Food; Fortified Food; Funding; Grant; Harvest; Health; Health Food; Human; Image; Institution; Laboratory Study; Lentils - dietary; Link; Marketing; Measures; Micronutrients; Molecular; Nutritional; Plant Physiology; Plants; Process; Research; Research Personnel; Resources; Route; Saskatchewan; Seeds; Selenium; Series; Soil; Solutions; Source; Spectrum Analysis; Testing; Toxic effect; United States National Institutes of Health; absorption; drinking water; improved; research study; selenium deficiency; uptake

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Arsenic in drinking water is affecting upwards of 30 million people in Bangladesh and surrounding areas. Our previous x-ray absorption spectroscopy studies revealed an intimate link between the toxicities of arsenic and selenium ? a molecule with a single atom of each provides a route to mutual detoxification. This and other evidence strongly indicates that the Bangladeshi arsenicosis actually causes people to become selenium deficient, a hypothesis currently under test by clinical trial of selenium supplements in Bangladesh. If the selenium deficiency hypothesis is proven, then a diet rich in selenium is essential to counter the arsenicosis and a staple food enriched in selenium would be the best way of providing this essential micronutrient. To this end we are investigating selenium enrichment of lentils. Preliminary results show that lentils readily take up and store selenium. Bangladesh imports lentils from several countries including Canada, where the lentil crop grows in selenium-rich soils of southern Saskatchewan. Selenium is essential for all humans, and such selenium-rich lentils are also a potential health food for North American markets. To more fully assess the nutritional benefit of the lentils we need to measure the selenium chemical form. We plan a series of experiments using x-ray absorption spectroscopy (XAS) to elucidate the chemical form and XAS imaging to visualize localization of selenium forms and other micronutrients in plant and seed. We will study laboratory grown plants as well as field-harvested seeds and will follow the seed through processing from plant to dinner plate. Determining the selenium molecular form in lentils will provide important information regarding the benefits of the lentils to human health, as well as fundamental information regarding the physiology of plant selenium uptake. If successful, selenium rich lentils could provide a practical solution to a health problem affecting tens of millions.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 饮用水中的砷在孟加拉国及其周边地区影响了3000万人。我们以前的X射线吸收光谱研究表明，砷和硒的毒性之间存在着紧密的联系？一个具有每个原子的分子提供了相互排毒的途径。这一证据和其他证据强烈表明，孟加拉国砷实际上会导致人们变得不足，这是当前通过孟加拉国硒补充剂临床试验检验的假设。如果证明了硒缺乏症的假设，那么富含硒的饮食对于应对砷的饮食至关重要，而富含硒的主食将是提供这种必需微量营养素的最佳方法。为此，我们正在研究小扁豆的硒富集。初步结果表明，小扁豆很容易占用并存储硒。孟加拉国从包括加拿大在内的几个国家进口扁豆，扁豆农作物在萨斯喀彻温省南部富含硒的土壤中生长。硒对所有人类都是必不可少的，这种富含硒的小扁豆也是北美市场的潜在健康食品。为了更充分地评估小扁豆的营养益处，我们需要测量硒化学形式。我们计划使用X射线吸收光谱（XAS）进行一系列实验，以阐明化学形式和XAS成像，以可视化硒形式和植物和种子中其他微量营养素的定位。我们将研究实验室种植的植物以及田间收获的种子，并通过从植物到餐盘加工来跟随种子。确定小扁豆中的硒分子形式将提供有关小扁豆对人类健康的好处的重要信息，以及有关植物硒摄取的生理学的基本信息。如果成功的话，富含硒的扁豆可以为影响数千万的健康问题提供实用的解决方案。