Clinical Samples

临床样本

• 批准号: 8307079
• 负责人: JOSEPH Wayne FAY
• 金额: $ 18.67万
• 依托单位: BAYLOR RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-05 至 2015-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8307079
• 关键词: Cataloging; Catalogs; Cells; Clinical; Clinical Data; Collaborations; Collection; Correlative Study; Data; Data Analyses; Data Collection; Ensure; Fostering; Future; Goals; Grant; Histocompatibility Testing; Human; Immune; Immune response; Immunization; Instruction; Laboratories; Lead; Location; Mission; Molecular Profiling; Names; Nomenclature; Process; Research Infrastructure; Research Personnel; Resources; Sampling; Scheme; Secure; Serum; Site; Specimen; Structure; System; Systems Analysis; Technology; Vaccines; Work; cost effective; data integration; data management; programs; repository; response; sample collection; sound

The proposed analysis of immune responses generated after immunization in this project entitled, "Systems Analysis of Vaccine Responses in Healthy and Hyporesponsive Humans", will take advantage of a collection of technologies on a variety of sample types. Indeed, the cumulative efforts from this project will generate an invaluable set of samples as a resource both for the proposed studies and future experimental questions. Thus, the necessary and important mission ofthe Clinical Sample Core is to insure that all specimens, clinical information that is generated by each of the projects will be systematically catalogued and tracked, adequately stored, and appropriately disseminated. The Clinical Sample Core will take advantage ofthe well-established infrastructure and successful collaboration between the investigators at BIIR and other participating sites. By consolidating the receipt, handling, and distribution of all samples from this U19 into one unified structure, the Clinical Sample Core will provide high quality clinical samples for the various analyses and immune studies proposed across all of the projects in the Center. The proposed infrastructure will optimize the use of samples and resources among the different investigators, providing the necessary synergy and integration in an efficient and cost-effective manner. Summarily, the Clinical Sample Core will allow us to carry out studies that we consider essential for achieving the overall goals of the Center by accomplishing the following significant objectives: 1) guarantee the integrity of incoming samples; 2) ensure the quality and consistency of the clinical data associated with the samples; 3) enforce a common sample ID nomenclature for all collection sites it which in turn will facilitate data integration and analysis within and across projects; 4) work with the broader data management scheme at BIIR that will help assure that the data generated in this project will be available for re-analysis in future projects.

本项目中对免疫后产生的免疫反应提出的分析，题为“系统 健康和低反应人类的疫苗反应分析”，将利用集合 各种样品类型的技术。事实上，该项目的累积努力将产生 宝贵的样本集作为拟议研究和未来实验问题的资源。 因此，临床样本核心的必要且重要的使命是确保所有样本、 每个项目生成的临床信息将被系统地编目和跟踪， 充分储存并适当传播。临床样本核心将利用 完善的基础设施以及 BIIR 和其他研究人员之间的成功合作 参与网站。 通过将 U19 的所有样本的接收、处理和分发整合到一个统一的结构中， 临床样本核心将为各种分析和免疫提供高质量的临床样本 中心所有项目中提出的研究。拟议的基础设施将优化使用 不同研究人员之间的样本和资源，提供必要的协同和整合 一种高效且具有成本效益的方式。总之，临床样本核心将使我们能够开展研究 我们认为通过完成以下任务对于实现中心的总体目标至关重要 重要目标： 1）保证来样的完整性； 2）保证质量和一致性 与样本相关的临床数据； 3) 对所有样本强制使用通用的样本 ID 命名法 收集站点，这反过来将促进项目内部和项目之间的数据集成和分析； 4）工作 BIIR 更广泛的数据管理方案将有助于确保在此生成的数据 项目将可用于未来项目中的重新分析。