A feasibility study of novel technologies to minimize motion-induced biases in functional and structural MRI of young, opioid-affected cohorts

一项新技术的可行性研究，旨在最大限度地减少受阿片类药物影响的年轻群体的功能和结构 MRI 中运动引起的偏差

基本信息

批准号：
10020594
负责人：
Allyson Patricia Mackey
金额：
$ 27.34万
依托单位：
UNIVERSITY OF PENNSYLVANIA
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-09-30 至 2021-03-31
项目状态：
已结题

项目摘要

PROJECT SUMMARY Opioid exposure, both prenatally and in early childhood, is associated with elevated risk for attention deficit hyperactivity disorder (ADHD), anxiety, low academic performance, and poor health. A major knowledge gap exists in understanding how opioid exposure impacts early brain development, giving rise to risk for adverse developmental outcomes. Neuroimaging studies in young children, ages 3-5, offer an opportunity to quantify developmental processes that are likely implicated in the differing trajectories of opioid-exposed children compared to their non-exposed peers. Unfortunately, the accuracy and reliability of neuroimaging methods in this cohort are not well-established. It is now well known that both structural and functional neuroimaging measures are prone to errors induced by subject motion. Moreover, it is known that many of the comorbid features of opioid exposure are likely to increase children’s in-scanner motion. This is on top of the existing challenges in achieving compliance for imaging studies with healthy, awake children in this age range. In total, this raises substantial concern that existing neuroimaging methods are not sufficiently motion-robust to be used in studies of children ages 3-5. We propose to address these concerns with a feasibility study, comparing the existing methods developed for the Adolescent Brain Cognitive Development (ABCD) study with novel methods we will develop and optimize for young children. We will evaluate our methods in a sample of 100 children, ages 3-5, recruited from the community in Philadelphia that has been hardest hit by the opioid crisis. We will test whether our novel technologies improve the quality of the raw imaging data, and reduce motion biases in the derived morphometric and functional measures. By collecting a broad set of measures on children’s environments (family drug use, family mental health, stress, social support), cognition, and mental health, we will determine predictors of successful imaging in order to inform sampling strategies in future studies of opioid exposure and brain development. Children whose data is more likely to be unusable will need to be oversampled, or statistically up-weighted, to ensure they are appropriately represented in the final sample. Preliminary data will also generate effect sizes for links between opioid exposure and neurocognitive development to inform decisions about imaging sample sizes in future studies. In sum, the primary outcomes of this work will be novel, validated structural and functional neuroimaging imaging methods for young children, and critical feasibility data to inform the design of future large-scale multi-center studies addressing developmental questions, particularly those related to opioid exposure.

项目概要产前和儿童早期接触阿片类药物与注意力缺陷风险升高相关多动症（ADHD）、焦虑、学习成绩低下和健康状况不佳是主要的知识差距。存在于了解阿片类药物暴露如何影响早期大脑发育，从而导致不良风险 3-5 岁幼儿的神经影像学研究提供了量化的机会。可能与阿片类药物暴露儿童的不同轨迹有关的发育过程与未暴露的同龄人相比。不幸的是，该队列中神经影像学方法的准确性和可靠性尚未确定。现在众所周知，结构和功能神经影像测量都容易出现由受试者引起的错误此外，众所周知，阿片类药物暴露的许多共病特征可能会增加。这是实现成像研究合规性的现有挑战的首要问题。总的来说，这引起了对现有神经影像学的极大关注。方法的运动鲁棒性不够，无法用于 3-5 岁儿童的研究。我们建议通过可行性研究来解决这些问题，比较现有的方法我们将开发和优化采用新方法的青少年大脑认知发展（ABCD）研究我们将从社区招募 100 名 3 至 5 岁的儿童作为样本，对我们的方法进行评估。在受阿片类药物危机打击最严重的费城，我们将测试我们的新技术是否有所改进。原始成像数据的质量，并减少导出的形态测量和功能中的运动偏差收集有关儿童环境的广泛措施（家庭吸毒、家庭心理）。健康、压力、社会支持）、认知和心理健康，我们将确定成功成像的预测因素以便为未来研究阿片类药物暴露和大脑发育的采样策略提供信息。数据更有可能无法使用，需要进行过采样或统计上加权，以确保它们可用初步数据还将生成各因素之间联系的效应大小阿片类药物暴露和神经认知发展为未来成像样本大小的决策提供信息研究。总之，这项工作的主要成果将是新颖的、经过验证的结构和功能神经影像学适用于幼儿的方法，以及为未来大型多中心设计提供信息的关键可行性数据针对发育问题的研究，特别是与阿片类药物暴露相关的问题。

项目成果

期刊论文数量（5）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Developmental Correlates of Accelerated Molar Eruption in Early Childhood.

儿童早期磨牙加速萌出的发育相关性。

DOI：
发表时间：
2023-10
期刊：
影响因子：
0
作者：
McDermott, Cassidy L;Lee, Janet;Park, Anne T;Tooley, Ursula A;Boroshok, Austin L;Hilton, Katherine;Linn, Kristin A;Mupparapu, Muralidhar;Mackey, Allyson P
通讯作者：
Mackey, Allyson P

Environmental influences on the pace of brain development.

环境对大脑发育速度的影响。

DOI：
发表时间：
2021-06
期刊：
影响因子：
0
作者：
Tooley, Ursula A;Bassett, Danielle S;Mackey, Allyson P
通讯作者：
Mackey, Allyson P

The Age of Reason: Functional Brain Network Development during Childhood.

理性时代：童年时期的功能性大脑网络发展。

DOI：
发表时间：
2022-11-02
期刊：
影响因子：
0
作者：
Tooley, Ursula A;Park, Anne T;Leonard, Julia A;Boroshok, Austin L;McDermott, Cassidy L;Tisdall, Matthew D;Bassett, Dani S;Mackey, Allyson P
通讯作者：
Mackey, Allyson P

Individual differences in T1w/T2w ratio development during childhood.

儿童时期 T1w/T2w 比率发育的个体差异。

DOI：
发表时间：
2023-08
期刊：
影响因子：
4.7
作者：
Boroshok, Austin L;McDermott, Cassidy L;Fotiadis, Panagiotis;Park, Anne T;Tooley, Ursula A;Gataviņš, Mārtiņš M;Tisdall, M Dylan;Bassett, Dani S;Mackey, Allyson P
通讯作者：
Mackey, Allyson P

Multilayer network associations between the exposome and childhood brain development.

暴露组与儿童大脑发育之间的多层网络关联。

DOI：
发表时间：
2023-10-25
期刊：
影响因子：
0
作者：
Simpson;Gataviņš, Mārtiņš M;Tooley, Ursula A;Boroshok, Austin L;McDermott, Cassidy L;Park, Anne T;Delgado Reyes, Lourdes;Bathelt, Joe;Tisdall, M Dylan;Mackey, Allyson P
通讯作者：
Mackey, Allyson P