2010 Pineal Cell Biology Gordon Research Conference

2010年松果体细胞生物学戈登研究会议

• 批准号: 7902655
• 负责人: DAVID Raymond WEAVER
• 金额: $ 1.2万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-02-06 至 2011-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7902655
• 关键词: Area; Biology; Breeding; Cell physiology; Cellular biology; Circadian Rhythms; Collaborations; Communication; Country; Data; Development; Developmental Biology; Discipline; Disease; Educational Status; Endocrine; Feedback; Fertilization; Future; Genetic; Goals; Government; Health; Hormones; Human; Laboratories; Link; Mammals; Medicine; Melatonin; Metabolic Diseases; Metabolism; Molecular; Nerve Degeneration; Neurodegenerative Disorders; Neurosciences; Output; Participant; Physiological; Physiology; Pineal gland; Regulation; Reproduction; Research; Research Personnel; Retinal; Scientist; Sleep; Sleep Wake Cycle; Texas; Therapeutic; Time; Translational Research; dietary supplements; human subject; insight; lectures; meetings; oncology; posters; programs; public health relevance; response; sleep regulation; symposium; tumor growth

DESCRIPTION (provided by applicant): Partial support is requested for the 11th Gordon Research Conference on Pineal Cell Biology to be held February 7-12 at Hotel Galvez in Galveston, Texas. The major objectives and long-term goals of the 2010 Gordon Research Conference on Pineal Cell Biology are to increase our understanding of the molecular and cellular function of the pineal gland, of how the rhythmic synthesis and release of the pineal hormone melatonin contributes to vertebrate physiology, and the importance of circadian rhythms in physiological functions and disease. Melatonin has a wide range of functions, ranging from effects on the sleep/wake cycle in humans to the control of photoperiodic responses in seasonally breeding mammals, and it is widely used as an over-the-counter dietary supplement. Thus, it is important that the physiology of the pineal gland and its principal output hormone, melatonin, be understood. The study of the pineal cell biology is inextricably linked to the study of circadian rhythms. An objective of this meeting is thus to explore aspects of circadian rhythms that are at the interface with melatonin and melatonin action, including regulation of sleep and circadian rhythms, metabolism, reproduction, retinal function and tumor growth. The specific aims of the Gordon Conference on Pineal Cell Biology are: 1) To provide a forum for communication of recent advances in the areas of Pineal Cell Biology, melatonin action, and circadian rhythms, leading to identification of key opportunities for future study, 2) To stimulate interaction among researchers studying different species and using a wide range of experimental and technical approaches, so as to promote understanding of the potential for interdisciplinary and collaborative research, 3) To promote collaboration by bringing together scientists from many different research groups and countries, and at different levels of training, and 4) To promote translational research by bringing together investigators studying human subjects in pineal and circadian research with those investigating other species. The Conference will achieve these aims by providing a forum for presentation of the latest advances. The Conference will bring together a diverse group of approximately 130 scientists from leading academic, industrial and government laboratories around the world to discuss current research directions and themes, and is expected to provide stimulating and intense discussion leading to insights and general principles emerging in pineal cell biology and related topics. The Gordon Conference format consists of lecture sessions in the morning and evening, with ample time for discussion. Poster sessions will allow additional participants to present data and receive feedback. The confirmed Invited Participants (listed in the Tentative Program) include experts using a broad variety of approaches, and from diverse disciplines, include neuroscience, (retinal biology, neurodegenerative diseases, and sleep medicine), developmental biology, genetics, metabolism, and oncology. Through convening such an interdisciplinary group of experts, the Conference will identify key areas for future research into the impact of melatonin and circadian rhythms on human health and disease. PUBLIC HEALTH RELEVANCE: The pineal hormone, melatonin, influences circadian organization, sleep/wake cycles, retinal function, metabolism and tumor growth. The Conference objective is to bring together leading scientists to discuss new developments in the field, to increase the level of interaction and cross-fertilization between disciplines and thus promote collaboration and translational research. The meeting will have health relevance through promoting an understanding of the contribution of melatonin and circadian rhythms, (and the therapeutic potential of manipulating them) in areas including sleep/wake regulation, and neurodegenerative, endocrine and metabolic disorders.

描述（由申请人提供）：要求将于2月7日至12日在德克萨斯州加尔维斯顿的Galvez举行的第11届戈登细胞生物学研究会议上提供部分支持。 2010年戈登细胞生物学研究会议的主要目标和长期目标是，我们对松果腺的分子和细胞功能的理解，关于松氨核激素褪黑激素的节奏合成和释放如何有助于脊椎动物生理学以及生理学和疾病中的虫子节奏的重要性。褪黑激素具有广泛的功能，从对人类的睡眠/唤醒周期的影响到控制季节性繁殖的光周期反应的控制，并且被广泛用作非处方饮食补充剂。因此，重要的是要理解松果体的生理及其主要输出激素褪黑激素。松果细胞生物学的研究与昼夜节律的研究密不可分。因此，这次会议的一个目的是探索与褪黑激素和褪黑激素作用界面处的昼夜节律的各个方面，包括调节睡眠和昼夜节律，代谢，繁殖，视网膜功能和肿瘤生长。戈登（Gordon）关于松果体细胞生物学会议的具体目的是：1）提供一个论坛，以交流松果细胞生物学，褪黑激素作用和昼夜节律的最新进展，从而确定未来研究的关键机会，2）刺激研究人员之间的互动，以研究不同的物种进行研究，并使用实验和技术的研究来宣传研究，以促进实验和技术的研究，并促进与技术的研究，以及促进与技术的研究，并促进了研究，并促进了研究，并促进了研究，并促进了研究人员的研究。通过将来自许多不同研究小组和国家的科学家汇集在一起​​，以及在不同级别的培训中的合作，以及4）通过将研究人类研究的研究人员与研究其他物种的研究者一起促进转化研究。会议将通过提供最新进展的论坛来实现这些目标。该会议将汇集来自世界各地领先的学术，工业和政府实验室的大约130名科学家组成的各种各样的小组，讨论当前的研究方向和主题，并有望提供刺激性和激烈的讨论，从而导致刺激性细胞生物学和相关主题中出现的见解和一般原则。戈登会议格式包括早晨和晚上的演讲，并有充足的讨论时间。海报会议将允许其他参与者提供数据并接收反馈。确认的受邀参与者（在暂定计划中列出）包括使用多种方法的专家，以及来自不同学科的专家，包括神经科学，（视网膜生物学，神经退行性疾病和睡眠医学），发育生物学，遗传学，代谢和癌症。通过召集这样的跨学科专家小组，会议将确定对褪黑激素和昼夜节律对人类健康和疾病的影响的未来研究的关键领域。 公共卫生相关性：松果激素，褪黑激素，影响昼夜节律组织，睡眠/唤醒周期，视网膜功能，代谢和肿瘤生长。会议的目标是将领先的科学家汇集在一起​​讨论该领域的新发展，以提高学科之间的互动和交叉利用水平，从而促进协作和转化研究。会议将通过促进褪黑激素和昼夜节律的贡献（以及操纵它们的治疗潜力）在包括睡眠/唤醒调节以及神经退行性，内分泌和代谢性疾病在内的地区的贡献（以及操纵它们的治疗潜力），从而具有健康相关性。